Abstract：
:In this study, we investigated the biochemical mechanisms in the adult rat hippocampus underlying the relationship between a terrified-sound induced psychological stress and spatial learning. Adult male rats were exposed to a terrified-sound stress, and the Morris water maze (MWM) has been used to evaluate changes in spatial learning and memory. The protein expression profile of the hippocampus was examined using two-dimensional gel electrophoresis (2DE), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and bioinformatics analysis. The data from the MWM tests suggested that a terrified-sound stress improved spatial learning. The proteomic analysis revealed that the expression of 52 proteins was down-regulated, while that of 35 proteins were up-regulated, in the hippocampus of the stressed rats. We identified and validated six of the most significant differentially expressed proteins that demonstrated the greatest stress-induced changes. Our study provides the first evidence that a terrified-sound stress improves spatial learning in rats, and that the enhanced spatial learning coincides with changes in protein expression in rat hippocampus.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Yang J,Hu L,Wu Q,Liu L,Zhao L,Zhao X,Song T,Huang Cdoi
10.1016/j.physbeh.2014.01.038subject
Has Abstractpub_date
2014-04-10 00:00:00pages
32-8eissn
0031-9384issn
1873-507Xpii
S0031-9384(14)00055-9journal_volume
128pub_type
杂志文章abstract：:Rats secrete saliva in response to heat. In the present study, details of thermal salivation were investigated using the FOK rat in comparison with Sprague-Dawley (SD), Donryu, and ACI rats. The FOK rat is a strain inbred for genotypic heat adaptation and endures heat for long periods. Conscious rats of all four strai...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00541-6
更新日期：1998-03-01 00:00:00
abstract：:Although cooperation represents a long-standing evolutionary puzzle, field studies on social carnivores have contributed greatly to our understanding of the selective forces favoring cooperative breeding. Despite these insights, our grasp of the proximate mechanisms facilitating cooperation in carnivores remains surpr...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：:Post-exertional exacerbation of symptoms is one of the major characteristics of chronic fatigue syndrome (CFS). In this study, we evaluated the hypothesis that disturbances in circadian chronobiological regulation may play a role in generating this phenomenon. We recorded physical activity for 6-day periods in 16 wome...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00808-9
更新日期：2002-09-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2007.07.005
更新日期：2007-12-05 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(87)90195-8
更新日期：1987-01-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1982-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00977-0
更新日期：2003-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(82)90176-7
更新日期：1982-06-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2017.09.009
更新日期：2017-11-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90306-8
更新日期：1984-04-01 00:00:00
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doi：10.1016/j.physbeh.2016.02.003
更新日期：2016-04-01 00:00:00
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更新日期：1984-09-01 00:00:00
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更新日期：1996-02-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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pub_type： 历史文章,杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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journal_title：Physiology & behavior
pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
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journal_title：Physiology & behavior
pub_type： 杂志文章
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