Rearing and step climbing behavior of X-linked hypophosphatemic (Hyp) mice.

Abstract:

:Hyp mice are a model for X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. Previous reports indicate alterations in the nervous system of these mice. The present study examined rearing and step climbing behavior in Hyp mice in the staircase test. We found that male Hyp mice have large reductions in both the number of rears and steps climbed when compared to normal male mice. When compared to normal female mice, female Hyp mice have a small reduction in the number of steps climbed but no significant reduction in the number of rears. However, they have greater rearing and climbing activity than male Hyp mice. These reductions in activity are not correlated with the severity of bone disease. Gonadectomy had no effect on activity in male mice but reduced activity comparably in both Hyp and normal female mice. We conclude that Hyp mice have altered behavior in the staircase test and that the magnitude and type of the alteration is influenced by the sex of the animal.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Vaughn LK,Quock RM,Meyer RA Jr

doi

10.1016/0031-9384(87)90195-8

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

131-4

issue

1

eissn

0031-9384

issn

1873-507X

pii

0031-9384(87)90195-8

journal_volume

40

pub_type

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