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The use of non-specific immunopotentiators in experimental Trypanosoma cruzi infection.

Abstract：

:The effects of levamisole, isoprinosine and Corynebacterium parvum on Trypanosoma cruzi (Y strain) experimental infection of mice were studied. In prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings. Levamisole and isoprinosine had no effect when used after infection. Electrocardiograms were obtained from all chronic chagasic mice. The most frequent changes were left atrial overload and first degree atrio-ventricular block. These findings became more frequent the longer the animals survived. The net effect of the non-specific immunopotentiators seems to depend on several factors: host immune state, severity of infection, dose and timing of drug administration. This probably explains the variable published results and the paradoxical findings of different laboratories.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Abath FG,Coutinho EM,Montenegro SM,Gomes YM,Carvalho AB

doi

10.1016/0035-9203(88)90268-4

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

73-6

issue

1

eissn

0035-9203

issn

1878-3503

journal_volume

82

pub_type

杂志文章

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