当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria.

No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria.

Abstract：

:Artemisinin derivatives are becoming the first-line treatment for uncomplicated malaria in areas with widespread resistance to chloroquine. Although generally safe and well tolerated, it has been suggested from animal experiments, and more recently from one human study with artemether-lumefantrine, that these compounds are potentially neurotoxic, affecting particularly the brainstem auditory pathways. We report here the auditory analyses of 15 volunteers who underwent an experimental human malaria infection and were treated with artemether-lumefantrine. The subjects underwent audiological examination before the start of the study, during infection, and after treatment. Examination included standard tone audiometry, high frequency tone audiometry and auditory brainstem response (ABR). No effects on hearing loss that were deemed to be caused by drug treatment were found using tone audiometry. ABR analysis similarly failed to demonstrate any auditory pathway damage in the volunteers after treatment. We have thus not found any clear evidence of a detrimental effect on the auditory system by artemether-lumefantrine treatment in uncomplicated malaria. Our results support the continued implementation of artemisinin derivatives in the fight against drug-resistant malaria.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

McCall MB,Beynon AJ,Mylanus EA,van der Ven AJ,Sauerwein RW

doi

10.1016/j.trstmh.2006.02.017

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

1098-104

issue

12

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(06)00137-4

journal_volume

100

pub_type

杂志文章

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