Abstract：
:Cicely Williams, in her original description of kwashiorkor, implied that deficiency of protein in the baby's food could be a main cause of the syndrome. The hallmark of kwashiorkor is oedema. According to the 'classical' theory, an inadequate intake of protein leads to a low plasma albumin concentration, which in turn causes oedema. This theory has been contested from several points of view: that hypoalbuminaemia is not the major factor determining the presence of oedema, and that there is no real evidence of dietary protein deficiency. The resolution of this question is of some importance from the point of view of public health diagnosis and prevention. A crucial point in the argument is the pathogenesis of oedema, which is discussed in some detail. Although it is clearly multifactorial, with electrolyte disturbances--potassium deficiency and sodium retention--playing an important role, it is contended that the classical theory is essentially correct. On the dietary side, recent experimental work supports the earlier view that the development of oedema depends on a relative deficiency of protein with a relative excess of energy. Comparisons of intakes with requirements are unconvincing in view of uncertainty about the validity of the estimates of children's needs for protein.
journal_name
Trans R Soc Trop Med Hygauthors
Waterlow JCdoi
10.1016/0035-9203(84)90053-1subject
Has Abstractpub_date
1984-01-01 00:00:00pages
436-41issue
4eissn
0035-9203issn
1878-3503journal_volume
78pub_type
杂志文章abstract：OBJECTIVES:Mid-upper arm circumference (MUAC) and weight-for-height Z-score (WHZ) identify different populations of children with severe acute malnutrition (SAM) with only some degree of overlap. In an urban slum in Bangladesh, we conducted a prospective cohort study on children assessed as being severely malnourished ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trt018
更新日期：2013-05-01 00:00:00
abstract：:Mice were immunized with 0.25 ml culture supernatant intraperitoneally and challenged with 5 x 10(4) Naegleria fowleri intranasally. Survival rate was 11% after one and 25% after three immunizing doses, compared to 0% in controls. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(79)90021-x
更新日期：1979-01-01 00:00:00
abstract：:Kidneys were studied by light microscopy in 246 consecutive autopsies in Cairo, Egypt. Glomerulonephritis was not related to the presence or intensity of either S. haematobium or S. mansoni infection, and mesangial thickening and proliferation were also unrelated to schistosome infection. Acute and chronic pyelonephri...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(76)90088-2
更新日期：1976-01-01 00:00:00
abstract：:The extent to which ivermectin treatments have an impact on onchocerciasis transmission is a matter of some concern. We investigated this issue in the Mbam valley, a hyperendemic focus located in a forest-savannah mosaic area of Cameroon. Parasitological examinations of 5-9-year-old children, who had never received an...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2003.11.010
更新日期：2004-09-01 00:00:00
abstract：:A sensitive high-performance liquid chromatographic method has been developed for the separation and quantitative estimation of melaminophenyl arsenical drugs used in the treatment of human and veterinary trypanosomiases. Five clinically relevant compounds (melarsoprol, melarsonyl potassium, cymelarsan, melarsen oxide...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(94)90117-1
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Rio de Janeiro (RJ) has been of major importance for the epidemiology of dengue viruses (DENVs) in Brazil. After the DENV 1-4 introductions in 1986, 1990, 2000 and 2011, respectively, the state has suffered explosive epidemics. We aimed to describe laboratorial, epidemiological and clinical aspects due to th...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trv006
更新日期：2015-04-01 00:00:00
abstract：:Chloroquine can no longer be recommended as the first-line treatment for uncomplicated malaria in several parts of Africa because of the increasing prevalence of chloroquine resistance. However, chloroquine was a highly effective treatment for malaria not only because of its ability to kill parasites quickly but also ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0035-9203(98)90962-2
更新日期：1998-01-01 00:00:00
abstract：:Resistance to the antifolate sulfadoxine-pyrimethamine (SP), the current mass-treatment antimalarial drug, is associated with selection of point mutations in dihydrofolate reductase and dihydropteroate synthase. Among these mutations, the leucine 164 dihydrofolate reductase mutation (Leu-164) is associated with higher...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2004.07.002
更新日期：2005-05-01 00:00:00
abstract：:Tropical sprue, a primary malabsorption syndrome affecting residents and visitors to several tropical regions, occurs in southern India in endemic and epidemic forms. The stomach, the small intestine and colon are affected and malabsorption results in nutrient deficiency. Enterocyte damage, the primary lesion in south...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/0035-9203(88)90247-7
更新日期：1988-01-01 00:00:00
abstract：:A progressive spastic myelopathy is one of the principal manifestations of the human T cell lymphotropic virus type 1. Recent research is reviewed on the geography and epidemiology of this specific form of tropical spastic paraparesis. First recognized in the Caribbean, Colombia and Japan, it is now also confirmed as ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/0035-9203(93)90467-5
更新日期：1993-03-01 00:00:00
abstract：:A case-control study was carried out in Kassala and Medani Maternity Hospitals in Sudan to investigate acute-phase proteins [haptoglobin, C-reactive protein (CRP), ferritin and albumin] in three groups of pregnant women (32 in each arm) comprising those with severe Plasmodium falciparum malaria or uncomplicated P. fal...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2012.06.004
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:The objective of study was to estimate the incremental cost-effectiveness ratio (ICER) of diagnostic options for visceral leishmaniasis (VL) in Brazil. METHODS:Six diagnostic tests were considered: IT LEISH, Kalazar Detect, DAT-LPC (DAT made in the Laboratório de Pesquisas Clínicas), IFAT, PCR and direct ex...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trw050
更新日期：2016-08-01 00:00:00
abstract：:The combination of chlorproguanil and dapsone is being considered as an alternative antimalarial to sulfadoxine-pyrimethamine in Africa, because of its greater efficacy against resistant parasites, and its shorter half-lives, which exert less selective pressure for the emergence of resistance. A triple artesunate-chlo...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2004.07.001
更新日期：2005-02-01 00:00:00
abstract：:Capuchin monkeys were resistant to reinfection with Schistosoma haematobium one year after exposure to 500 cercariae, but worms in these monkeys continued to produce normal numbers of eggs. Monkeys were apparently completely refractory to reinfection when challenged 2-5 years after an initial exposure of 1000 to 2000 ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90280-5
更新日期：1988-01-01 00:00:00
abstract：:Between March 1982 and March 1983 rotaviruses were detected in faecal specimens from 193 (19%) of 1020 Jamaican children under 5 years old with acute gastroenteritis. The excretion of rotaviruses in a control group of non-diarrhoeal children was only 1.4%. Rotaviruses were detected more frequently in the cooler months...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90294-5
更新日期：1988-01-01 00:00:00
abstract：:Forty human strains of Leishmania infantum isolated in 1985-99 from 17 patients with repeated cutaneous, mucosal or visceral leishmaniasis episodes in Catalonia (Spain) were examined by isoenzyme electrophoresis. Six zymodemes were revealed: MON-1, MON-24, MON-28, MON-29, MON-33 and MON-34. In 2 patients 2 different z...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(02)90235-x
更新日期：2002-01-01 00:00:00
abstract：:The bacterial flora of the upper intestine has been examined in symptomatic expatriate adults with mild tropical malabsorption, without steatorrhoea, persisting for many months after return to a western environment. Seven of the 11 patients had enterobacteria in luminal fluid or mucosal samples in numbers ranging from...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(80)90194-7
更新日期：1980-01-01 00:00:00
abstract：:An outbreak of Ross River virus infection (epidemic polyarthritis), which occurred in American Samoa between August 1979 and January 1980, is described. On the basis of a serological survey performed near the end of the epidemic, it is estimated that at least 13,500 people were infected. Ross River virus was isolated ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(81)90112-7
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This stu...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trt091
更新日期：2013-12-01 00:00:00
abstract：:An analysis was carried out of the mortality rate on the medical wards of the University College Hospital, Ibadan, over a 14-year period (1960-73). A total of 4,568 cases were reviewed with an annual death rate of between 300 and 400. Most of the deaths resulted from cardiovascular diseases, especially hypertension, t...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(76)90131-0
更新日期：1976-01-01 00:00:00
abstract：:Indirect enzyme-linked immunosorbent assay (ELISA) allows sensitive detection of serum immunoglobulin (Ig) G against a soluble extract of Strongyloides stercoralis infective larvae. In this study, 40/40 (100%) human strongyloidiasis sera had high levels of anti-S. stercoralis IgG, but 30/40 (75%) filariasis sera, and ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(93)90477-8
更新日期：1993-03-01 00:00:00
abstract：:A Swedish tourist who had visited Kenya fell ill with Plasmodium falciparum malaria 11 days after returning home, in spite of taking pyrimethamine (50 mg weekly) as malaria prophylaxis. Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0.30 mumol/l cleared the patent parasitaemia and the...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(81)90093-6
更新日期：1981-01-01 00:00:00
abstract：:Cerebral gnathostomiasis is a severe form of human infection caused by Gnathostoma spinigerum. We report sequential brain imaging in serologically proven cerebral gnathostomiasis. The clinical and radiographic correlation showed the probable route taken by the parasite during its migration through the central nervous ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2008.09.011
更新日期：2009-01-01 00:00:00
abstract：:In vitro gametocytogenesis of Plasmodium falciparum was observed in all 22 isolates established in this laboratory. Gametocytes were produced in variable numbers--up to 3% of red cells--for a limited period of time after which this stage was seen only very sporadically. Complete maturation of microgametocytes in vitro...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(82)90289-9
更新日期：1982-01-01 00:00:00
abstract：:Transient rises in parasitaemia occur commonly during the treatment of falciparum malaria but their prognostic significance has not been well defined. Twelve-hourly parasite counts from 133 malaria patients who were ultimately cured were therefore compared with counts from 97 therapeutic failures to determine if incre...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(92)90217-z
更新日期：1992-07-01 00:00:00
abstract：:Ochratoxin A (OA) is a naturally occurring mycotoxin with nephrotoxic properties that can contaminate plant food products. OA concentrations were assessed in commonly consumed food items in the North Central Province of Sri Lanka, where chronic kidney disease is diagnosed at epidemic proportions. Ninety-eight randomly...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2008.04.007
更新日期：2008-07-01 00:00:00
abstract：:The Andaman and Nicobar Islands, Union Territory of India, are home to six primitive tribes, namely the Great Andamanese, Onges, Jarawas and Sentinelese (Negrito race), and the Shompens and Nicobarese (Mongoloid race). These tribes account for about 8% of the island's population and the Nicobarese constitute >95% of t...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2008.04.044
更新日期：2008-08-01 00:00:00
abstract：:The efficiency was tested of the Haematocrit Centrifugation Technique (HCT) and the miniature Anion-Exchange Centrifugation Technique (mAECT) for demonstrating trypanosomes in the blood of four antelopes experimentally infected with Trypanosoma brucei gambiense in Liberia. During simultaneous daily application of both...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(84)90244-x
更新日期：1984-01-01 00:00:00
abstract：:Although intestinal helminth and protozoan infections are prevalent throughout the world, their impact is poorly known. Nevertheless, the morbidity and mortality that occur have stimulated research into host resistance and pathogenesis. Unfortunately, despite an increasing knowledge base, the actual effector molecules...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/0035-9203(86)90372-x
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Lassa fever (LF) is an acute viral haemorrhagic infection, endemic in West Africa. Confirmatory diagnosis and treatment (ribavirin) is difficult, expensive, and restricted to specialised hospitals. Among confirmed and suspected LF cases, we report on clinical and laboratory features, timing and administratio...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/tru009
更新日期：2014-03-01 00:00:00
