Abstract：
:A hypervariable deoxyribonucleic acid (DNA) probe was isolated by screening a Leishmania donovani genomic DNA library with L. donovani total DNA. The probe was used to characterize L. donovani stocks on the basis of restriction fragment length polymorphisms (RFLPs). The molecular karyotype of the same stocks was examined by orthogonal field alternation gel electrophoresis. On the basis of the observed RFLPs Mediterranean L. donovani infantum and South American L. donovani chagasi stocks were more similar to one another than they were to Indian L. donovani donovani or African L. donovani stocks. This conclusion was also supported by the studies on molecular karyotype. The probe also showed African L. donovani stocks to be heterogeneous in their restriction fragment patterns: the patterns of Indian stocks were, by contrast, relatively homogeneous. Certain L. donovani stocks that appeared to be closely related on the basis of RFLPs and isoenzyme data were markedly different in karyotype, demonstrating the rapidity of chromosome evolution in Leishmania donovani.
journal_name
Trans R Soc Trop Med Hygauthors
Bishop RP,Akinsehinwa Fdoi
10.1016/0035-9203(89)90377-5subject
Has Abstractpub_date
1989-09-01 00:00:00pages
629-34issue
5eissn
0035-9203issn
1878-3503journal_volume
83pub_type
杂志文章abstract：:Indigenous natural drugs are in common use in Zimbabwe because modern life-saving drugs are beyond the reach of nearly 85% of the population. These natural drugs have caused a number of poisoning cases. In a study of the records of four hospitals from 1971 to 1982, carried out to see how many people had been poisoned ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(86)90339-1
更新日期：1986-01-01 00:00:00
abstract：:From the early 1900s, visceral leishmaniasis (VL; kala-azar) has been among the most important health problems in Sudan, particularly in the main endemic area in the eastern and central regions. Several major epidemics have occurred, the most recent--in Western Upper Nile province in southern Sudan, detected in 1988--...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(01)90218-4
更新日期：2001-04-01 00:00:00
abstract：:Simple pit latrines often represent the cheapest form of sanitation for poor communities. However, simple latrines lack a concrete slab and are therefore classified as an unimproved form of sanitation. This study collected soil samples in simple pit latrines and analysed them for the presence of helminth eggs; 71% of ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2012.08.002
更新日期：2012-11-01 00:00:00
abstract：:Cutaneous leishmaniasis (CL) is endemic in Algeria where two forms have been previously described, the sporadic form caused by Leishmania infantum in the north and the cutaneous form caused by L. major in central and southern parts of the country. During 2005, a CL outbreak occurred in the province of Ghardaïa, locate...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2009.04.013
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Antibiotic resistance is a global health crisis and irrational prescribing behaviour has been identified as a contributing factor. The current study aimed to assess the knowledge of, attitudes towards and practices regarding antibiotic prescribing of medical doctors providing free healthcare services in the ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trz137
更新日期：2020-06-01 00:00:00
abstract：:To compare the characteristics of women and men with Trypanosoma brucei gambiense trypanosomiasis, all 3231 cases treated in Nioki hospital, Democratic Republic of Congo, from 1982 to 2000 were reviewed for demographic information, date and mode of diagnosis, pre-treatment cerebrospinal fluid (CSF) examination, treatm...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(02)90380-9
更新日期：2002-07-01 00:00:00
abstract：:The origin of illness and pathology in malaria is now largely attributed to high levels of circulating tumour necrosis factor (TNF), released from cells of macrophage lineage after triggering by the products of malarial schizogony. The role of lymphocytes and their products in malarial pathology is not yet known. This...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(92)90144-2
更新日期：1992-11-01 00:00:00
abstract：:Neither high theoretical efficacy of disease control tools, nor diagnostic accuracy, nor good compliance, nor adequate coverage can lead on its own to the final goal of community effectiveness. There is a complex relationship between these factors. The different steps in the process leading to effective health care in...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/0035-9203(93)90070-7
更新日期：1993-09-01 00:00:00
abstract：:On return from duty in North Solomons Province (including Bougainville Island), Papua New Guinea, 586 Australian Defence Force personnel received either primaquine (14-d) or tafenoquine (3-d) post-exposure malaria prophylaxis. Within 12 months, 6 of the 214 volunteers receiving primaquine and 7 of 378 receiving tafeno...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(02)90351-2
更新日期：2002-11-01 00:00:00
abstract：:Cold, acidified anthrone was used to test 200 wild-caught sandflies (Phlebotomus ariasi females) for the presence of fructose. This sugar, or others with a fructose moiety, were demonstrable in 157 (79%) of the flies; proportions of flies positive in different tests ranged from 44 to 91%. Higher proportions of flies g...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(80)90100-5
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND:Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This stu...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trt091
更新日期：2013-12-01 00:00:00
abstract：:In sub-Saharan Africa, anaemia in pregnancy results from multiple causes including malaria, iron deficiency and haemoglobinopathies. In a cross-sectional study among 530 pregnant women in Ghana in November-December 1998, red blood cell indices were analysed with respect to malaria, serum concentrations of ferritin and...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(00)90057-9
更新日期：2000-09-01 00:00:00
abstract：:Cystic echinococcosis (CE), caused by Echinococcus granulosus, and alveolar echinococcosis (AE), due to E. multilocularis, are endemic to large areas of north and northwest China. Here we review features of a severe focus of AE and CE in Ningxia Hui Autonomous Region (NHAR), northwest China. We describe for NHAR the r...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2008.01.007
更新日期：2008-04-01 00:00:00
abstract：:Sulfadoxine-pyrimethamine (SP) and co-trimoxazole were both effective in reducing fever, clearing parasitaemia and improving anaemia in children aged < 5 years with uncomplicated malaria in 2 Kenyan endemic sites, Oyugis in the west and Tiwi on the coast. We compared the efficacy of these 2 regimens (in May-July 1998)...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0035-9203(01)90107-5
更新日期：2001-11-01 00:00:00
abstract：:Tuberculosis (TB) remains a major cause of mortality despite availability of effective chemotherapy. This study was performed to identify contributing factors for poor outcome during anti-tuberculosis treatment at a teaching hospital chest clinic. Medical records of registered patients treated for TB between 1 January...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2011.07.017
更新日期：2011-12-01 00:00:00
abstract：:Indirect enzyme-linked immunosorbent assay (ELISA) allows sensitive detection of serum immunoglobulin (Ig) G against a soluble extract of Strongyloides stercoralis infective larvae. In this study, 40/40 (100%) human strongyloidiasis sera had high levels of anti-S. stercoralis IgG, but 30/40 (75%) filariasis sera, and ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(93)90477-8
更新日期：1993-03-01 00:00:00
abstract：:The relation between Plasmodium falciparum malaria and symptomatic human immunodeficiency virus 1 (HIV-1) infection was investigated in paediatric and adult patients in Kampala, Uganda, from 1987 to 1989. Both infections contributed largely to hospital morbidity. Of 1527 clinically suspicious in-patients, 61% were pos...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90306-y
更新日期：1990-05-01 00:00:00
abstract：:The spread of chloroquine-resistant malaria has led to a resurgence of quinine in clinical use. One of the well-known side effects of quinine, reversible hearing loss, is closely related to the plasma concentration. We suggest that this hearing effect could be used as an aid in therapy control when quinine drug assay ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90069-q
更新日期：1990-11-01 00:00:00
abstract：:Persistent diarrhoea is a major cause of morbidity and mortality in AIDS patients, and consequently an important public health problem in sub-Saharan Africa. Although intestinal protozoa and bacteria are detected in many of these patients, a substantial proportion of disease remains unexplained even after intensive in...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)80034-2
更新日期：2003-09-01 00:00:00
abstract：:Malaria remains an important health problem in Bangladesh, with approximately 14 million people at risk. Antimalarial drug resistance is a major obstacle to the control of malaria in endemic countries. In 2012, Bangladesh reported an estimated 29 522 malaria episodes, of which 94% were reported as being caused by Plas...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1093/trstmh/trt088
更新日期：2013-12-01 00:00:00
abstract：:A serological survey was carried out to determine the frequency of distribution of hydatid antibodies in Pondicherry during 1981 to 1984. 1325 apparently normal sera and 109 sera from clinically suspected hydatid disease cases were screened by the indirect haemagglutination (IHA) test. Results showed a diagnostic titr...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90037-x
更新日期：1987-01-01 00:00:00
abstract：:The epidemiological, clinical and laboratory findings of 27 patients with visceral leishmaniasis (VL) and six with mucosal leishmaniasis (ML) in Sudan are described. The diagnosis was confirmed by the demonstration of amastigotes in bone-marrow in 20 cases with VL (80%) and impression smears in 2 cases with ML. The en...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(91)90220-s
更新日期：1991-07-01 00:00:00
abstract：:Gross haematuria caused by lymphatic filariasis has been rarely reported. An adult woman living in a filarial-endemic area presented at a hospital in Orissa, India, in July 2004, with painless gross haematuria without any associated symptoms, such as dysuria, abdominal pain and fever. Urine microscopy revealed many er...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2008.02.008
更新日期：2008-05-01 00:00:00
abstract：:Among infectious diseases, tuberculosis is the leading cause of death, killing around 3 million people each year. Most cases occur in young adults but it is also a major cause of illness and death in children. The problem has been exacerbated in recent years by the HIV pandemic and by the emergence of multidrug resist...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(99)90278-x
更新日期：1999-03-01 00:00:00
abstract：:The majority of deaths from cerebral malaria occur within 48 h after admission to hospital. Because of the possibility of inadequate treatment within this period, the use of a loading dose of quinine has been proposed. We reviewed clinical and laboratory data for 113 children with cerebral malaria, who were treated wi...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0035-9203(98)91032-x
更新日期：1998-05-01 00:00:00
abstract：:Eight weeks following infection with Schistosoma mansoni ICR strain mice showed much more marked hepatic fibrosis than did C57BL/6 mice or hamsters. None the less, extracts of the hepatic granulomata of these animals had similar fibroblast stimulating activity when assayed in vitro. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(85)90369-4
更新日期：1985-01-01 00:00:00
abstract：:One-third of the world's population burn organic material such as wood, dung or charcoal (biomass fuel) for cooking, heating and lighting. This form of energy usage is associated with high levels of indoor air pollution and an increase in the incidence of respiratory infections, including pneumonia, tuberculosis and c...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2008.05.028
更新日期：2008-09-01 00:00:00
abstract：:To investigate Mycobacterium vaccae immunotherapy in the treatment of human tuberculosis and to assess longer-term outcomes following treatment for tuberculosis patients, a double-blind placebo-controlled Phase-2 clinical trial was set up in the Mseleni and Manguzi health wards in north-eastern KwaZulu, South Africa. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0035-9203(00)90088-9
更新日期：2000-09-01 00:00:00
abstract：:The indirect fluorescent antibody (IFA) test and the amoebic gel diffusion (AGD) test were assessed as tools for differentiating between past and present infection in invasive amoebiasis; in the case of the IFA test the Entamoeba histolytica-specific IgG and IgM were monitored. In a pilot study in which sera from 56 p...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(84)90115-9
更新日期：1984-01-01 00:00:00
abstract：:As reduced red cell deformability (RCD) can contribute to derangement of the microcirculation, a central feature in the pathogenesis of severe malaria, RCD was measured with a laser diffraction technique in 232 consecutive patients with falciparum malaria on the Kenyan coast, of whom 99 had severe disease. RCD on admi...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(02)90100-8
更新日期：2002-05-01 00:00:00
