Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.

abstract：:Recent investigations on the distribution of human and canine leishmaniasis, and on the vectors and wild reservoirs of the disease in foci in Tuscany have stimulated a retrospective evaluation of human leishmaniasis of the whole region. From a study of the literature, of statistical reports (ISTAT) and of unpublished ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Bettini S,Maroli M,Gradoni L

更新日期：1981-01-01 00:00:00

abstract：:A total of 1,197 wild animals from Pará State north Brazil, were examined for haematozoa. Trypanosoma cruzi-like parasites were found in 13 different species, and were particularly common in a variety of marsupials (Didelphidae), porcupines (Coendou spp.), armadillos (Dasypus novemcinctus) and coatimundis(Nasua nasua)...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Lainson R,Shaw JJ,Fraiha H,Miles MA,Draper CC

更新日期：1979-01-01 00:00:00

abstract：:A 29-year-old Dutch tourist of the Caucasian race had to break her return journey from Indonesia as she developed dengue haemorrhagic fever. She appeared to have been infected on Bali. Serological investigation revealed very high antibody titres against dengue virus types 1 and 3 and a moderately high titre against ty...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： van Tongeren HA

更新日期：1983-01-01 00:00:00

abstract：:Microfilariae of Wuchereria bancrofti and Brugia pahangi, which were inoculated into Meriones unguiculatus and Mastomys natalensis respectively, were found in the peripheral blood of the rodents until the ninth day after infection, but no microfilarial periodicity was observed. Microfilariae of W. bancrofti disappeare...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Zielke E

更新日期：1980-01-01 00:00:00

abstract：:A hypervariable deoxyribonucleic acid (DNA) probe was isolated by screening a Leishmania donovani genomic DNA library with L. donovani total DNA. The probe was used to characterize L. donovani stocks on the basis of restriction fragment length polymorphisms (RFLPs). The molecular karyotype of the same stocks was exami...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Bishop RP,Akinsehinwa F

更新日期：1989-09-01 00:00:00

abstract：:Severe febrile illness is a major cause of adult hospital admission in Africa. Studies of non-malarial fever come largely from children or from high HIV prevalence settings. This prospective study of adult admissions with severe febrile illness in a malaria-endemic area with moderate/low HIV prevalence investigated ad...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Nadjm B,Mtove G,Amos B,Walker NF,Diefendal H,Reyburn H,Whitty CJ

更新日期：2012-11-01 00:00:00

abstract：:Leishmanial antigen in circulating immune complexes (CIC) from sera of cotton-rats experimentally infected with Leishmania donovani and visceral leishmaniasis patients (VLP) was detected using a polyethylene glycol (PEG) enzyme-linked immunosorbent assay (PEG-ELISA). The immune complexes were precipitated in the cold ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Azazy AA,Devaney E,Chance ML

更新日期：1994-01-01 00:00:00

abstract：:We evaluated amodiaquine as a replacement drug for treating falciparum malaria in an area of Pakistani Punjab where chloroquine-resistant Plasmodium falciparum has recently emerged. Amodiaquine appeared to be 4 to 8 times more effective than chloroquine when P. falciparum isolates were tested in vitro. However, the re...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Khaliq AA,Fox E,Sarwar M,Strickland GT

更新日期：1987-01-01 00:00:00

abstract：:Indoor-resting anopheline mosquitoes were collected from Obuasi, Ghana, and were identified morphologically and by PCR as Anopheles funestus Giles. Wild-caught females were induced to lay eggs. Samples of F1 progeny from each family were divided into cohorts and were either exposed to DDT and permethrin or were stored...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Okoye PN,Brooke BD,Koekemoer LL,Hunt RH,Coetzee M

更新日期：2008-06-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) epidemic is associated with a marked increase of tuberculosis cases. The influence of HIV on diagnostic methods for tuberculous lymphadenitis is less clear. In an environment of high HIV and tuberculosis prevalence in Blantyre, Malawi, a prospective study compared results of basi...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Bekedam HJ,Boeree M,Kamenya A,Liomba G,Ngwira B,Subramanyam VR,Harries AD

更新日期：1997-05-01 00:00:00

abstract：:This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Davey G,Tekola F,Newport MJ

更新日期：2007-12-01 00:00:00

abstract：:Plasmodia infect the liver for about 7 days before subsequently infecting the blood. Present prophylaxis against Plasmodium falciparum malaria employs agents that primarily kill blood stages and must be continued for 28 days after the last exposure. Atovaquone-proguanil (Malarone) is a new antimalarial agent that is l...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Berman JD,Nielsen R,Chulay JD,Dowler M,Kain KC,Kester KE,Williams J,Whelen AC,Shmuklarsky MJ

更新日期：2001-07-01 00:00:00

abstract：:When cross-sectional surveys are used to evaluate malaria intervention programmes in the community, the prevalence of morbidity is difficult to assess because of the fluctuating nature of malarial fever. We have therefore investigated the impact of bed net usage on 2 surrogate markers of malarial morbidity: (i) elevat...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： McGuire W,D'Alessandro U,Olaleye BO,Thomson MC,Langerock P,Greenwood BM,Kwiatkowski D

更新日期：1996-01-01 00:00:00

abstract：:TB remains a very significant global health burden. There is an urgent need for better tools for TB control, which include an effective vaccine. Bacillus Calmette-Guérin (BCG), the currently licensed vaccine, confers highly variable protection against pulmonary TB, the main source of TB transmission. Replacing BCG com...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Manjaly Thomas ZR,McShane H

更新日期：2015-03-01 00:00:00

abstract：:Neither high theoretical efficacy of disease control tools, nor diagnostic accuracy, nor good compliance, nor adequate coverage can lead on its own to the final goal of community effectiveness. There is a complex relationship between these factors. The different steps in the process leading to effective health care in...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Tanner M,Lengeler C,Lorenz N

更新日期：1993-09-01 00:00:00

abstract：:Although known for many years, non-filarial elephantiasis remains a public health problem in tropical Africa, including the farming community of Ethiopia. The problem may be exacerbated in women who shoulder most of the burden of agricultural labour in the countryside. The intention of this brief review is to emphasis...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Animut A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Low birth weight is known to be associated with postnatal growth failure. It is not yet established that both conditions are determinants of psychomotor development. The study investigated whether or not low birth weight leads to delayed psychomotor development of a child, and whether it can be mitigated by ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Avan BI,Raza SA,Kirkwood BR

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:To investigate the spatial distribution of congenital syphilis (CS) and its association to social vulnerability indexes in northeast Brazil. METHODS:This was an ecological study referring to all cases of CS and CS deaths recorded in the northeast region of Brazil from 2008 to 2015. Data were obtained from t...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： de Souza CDF,Machado MF,Correia DS,do Carmo RF,Cuevas LE,Santos VS

更新日期：2020-09-01 00:00:00

abstract：:From June to December 1985 273 cases of hepatitis and jaundice were diagnosed in Maun, northern Botswana. It was known before the outbreak that most adults were immune to hepatitis A virus, most had markers indicating past infection with hepatitis B virus (HBV), there was a mean prevalence of 13.6% (57/418) HBsAg carr...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Byskov J,Wouters JS,Sathekge TJ,Swanepoel R

更新日期：1989-01-01 00:00:00

abstract：:In developing countries, micronutrient deficiencies are common and associated with poor pregnancy outcomes, which may in turn have longer-term effects on human health. The peri-conceptional period represents a particularly sensitive window of feto-placental development, during which suboptimal maternal micronutrition ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Owens S,Fall CH

更新日期：2008-02-01 00:00:00

abstract：:A study was conducted in rural Malawi to verify (a) whether the Partec CyFlow Counter((R)) for CD4+ T-cell lymphocyte counting in HIV-positive individuals could be introduced into a district hospital laboratory and (b) whether it would produce CD4 counts of acceptable quality. CD4+ cell counting was performed using th...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Fryland M,Chaillet P,Zachariah R,Barnaba A,Bonte L,Andereassen R,Charrondière S,Teck R,Didakus O

更新日期：2006-10-01 00:00:00

abstract：:Using two serological techniques, eight Nigerian West Nile virus isolates were investigated to determine antigenic relationships among them, and to find out if these virus isolates were related to West Nile virus strains from the different zoogeographic areas of the world. One virus differed significantly from the sev...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Odelola HA,Fabiyi A

更新日期：1976-01-01 00:00:00

abstract：:A study was conducted in 1997 to compare the accuracy of presumptive diagnosis of malaria in children aged 1-9 years performed by caretakers of the children to that of health centre staff in 2 ecological zones in southern Ghana. Similar symptoms were reported in the children at home and at the health centre. In the ho...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Dunyo SK,Afari EA,Koram KA,Ahorlu CK,Abubakar I,Nkrumah FK

更新日期：2000-05-01 00:00:00

abstract：:We describe 3 returned travellers who developed profuse watery diarrhoea associated with marked blood eosinophilia. Delayed appearance of ova in stool samples caused difficulty in establishing diagnoses of acute hookworm infection. Low activity of ivermectin against hookworm resulted in failure of empiric treatment wi...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Lawn SD,Grant AD,Wright SG

更新日期：2003-07-01 00:00:00

abstract：:The use of an indirect fluorescent antibody test (IFAT) performed in a "sandwich" technique has demonstrated: (i) the usefulness of the test for the diagnosis of Trypanosoma cruzi infection in the opossum Didelphis marsupialis; (ii) the existence of differences in the serological response of the opossum, that were rel...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Jansen AM,Moriearty PL,Castro BG,Deane MP

更新日期：1985-01-01 00:00:00

abstract：:The effect of levamisole hydrochloride and mebendazole on Angiostrongylus malaysiensis infection in albino rats was studied. Animals at different stages of infection were treated with various oral doses of levamisole and mebendazole with the aim of finding an effective treatment regime. Levamisole was most effective f...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ambu S,Kwa BH,Mak JW

更新日期：1982-01-01 00:00:00

abstract：:1,003 patients with meningococcal disease admitted to a single hospital during the course of a three-month epidemic were studied. A progressive decline in mortality, especially among patients with acute meningococcaemia, and a falling incidence of systemic and severe neurological complications among patients with meni...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Greenwood BM,Cleland PG,Haggie MH,Lewis LS,Macfarlane JT,Taqi A,Whittle HC

更新日期：1979-01-01 00:00:00

abstract：:From 1993 to 1996, an entomological survey was conducted in the village of Ndiop, Senegal, as part of a research programme on malaria epidemiology and the mechanisms of protective immunity. Mosquitoes were captured on human bait and by indoor spraying. Species from the Anopheles gambiae complex were identified using t...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Fontenille D,Lochouarn L,Diatta M,Sokhna C,Dia I,Diagne N,Lemasson JJ,Ba K,Tall A,Rogier C,Trape JF

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:To present the long-term outcome of multidrug-resistant tuberculosis (MDR TB) patients. METHODS:An observational study of 291 MDR TB cases that were diagnosed from 1990 to 2011 at the Fukujuji Hospital in Japan. RESULTS:The frequency of relapse after cure was 3/168 (1.8%) during a mean follow-up of 4.4 year...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Yoshiyama T,Morimoto K,Okumura M,Sasaki Y,Ogata H,Shiraishi Y,Kudou S

更新日期：2014-09-01 00:00:00

abstract：:Pneumocystis carinii occurs in 60-65% of cases of acquired immunodeficiency syndrome (AIDS) in Europe and North America. Its prevalence in Africa is unknown, however, due to a lack of suitable investigative techniques. Initial studies suggest that this parasitic complication may be lower in Africa. An investigation of...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Carme B,Mboussa J,Andzin M,Mbouni E,Mpele P,Datry A

更新日期：1991-01-01 00:00:00