Abstract:
:The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Sani G,Kotzalidis GD,Panaccione I,Simonetti A,De Chiara L,Del Casale A,Ambrosi E,Napoletano F,Janiri D,Danese E,Girardi N,Rapinesi C,Serata D,Manfredi G,Koukopoulos AE,Angeletti G,Nicoletti F,Girardi Pdoi
10.4306/pi.2014.11.1.95subject
Has Abstractpub_date
2014-01-01 00:00:00pages
95-101issue
1eissn
1738-3684issn
1976-3026journal_volume
11pub_type
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