Low-dose acetazolamide in the treatment of premenstrual dysphoric disorder: a case series.

Abstract:

:The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Sani G,Kotzalidis GD,Panaccione I,Simonetti A,De Chiara L,Del Casale A,Ambrosi E,Napoletano F,Janiri D,Danese E,Girardi N,Rapinesi C,Serata D,Manfredi G,Koukopoulos AE,Angeletti G,Nicoletti F,Girardi P

doi

10.4306/pi.2014.11.1.95

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

95-101

issue

1

eissn

1738-3684

issn

1976-3026

journal_volume

11

pub_type

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