Abstract:
:Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with major depressive disorder (MDD) and compared the EEG relative powers of 9 scalp regions. Compared to the MDD group, the AD group had a higher global theta relative power (p=0.021). In the MDD group, beta relative power was higher in the mid-central region than in the left or right central regions (p<0.01). The prediction model that included global theta relative power and regional beta index was able to discriminate AD from MDD (AUC=0.893, p=0.002). A combination of global theta relative power and intra-individual regional differences in beta may differentiate early AD from MDD with cognitive impairment.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Lee K,Han JW,Kim KWdoi
10.4306/pi.2017.14.5.708subject
Has Abstractpub_date
2017-09-01 00:00:00pages
708-711issue
5eissn
1738-3684issn
1976-3026journal_volume
14pub_type
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