Abstract:
Objective:Research has shown that intranasal oxytocin affects social cognition and behavior; however, its effects vary based on social context, individual characteristics and dose. The present study aimed to determine effective dose of oxytocin spray on emotion recognition in healthy Korean males. Methods:The study followed a randomized, double-blind, placebo-controlled design. Thirty-seven Korean males underwent two experimental sessions, with one week in between. They received either 32 (n=19) or 40 (n=18) international units (IU) of oxytocin and placebo, and then completed a face emotion recognition task. The effect of oxytocin on emotion recognition was examined using repeated measures analysis of variance (ANOVA) for each dose condition. Results:The higher dose (40 IU) was found to improve recognition of happy faces, while the lower dose (32 IU) had no effect. There were no statistical differences in age, education, attachment style or empathic ability between the two dose groups. Conclusion:The results suggest that oxytocin increases the ability of Korean males to recognize positive emotion, and this effect is dose-dependent. Additional studies evaluating the effect of higher doses of oxytocin on social cognition will help to determine the optimal dose for Korean populations.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Shin NY,Park HY,Jung WH,Kwon JSdoi
10.30773/pi.2018.02.19subject
Has Abstractpub_date
2018-07-01 00:00:00pages
710-716issue
7eissn
1738-3684issn
1976-3026pii
pi.2018.02.19journal_volume
15pub_type
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