The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations.

Abstract:

OBJECTIVE:Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study is to elucidate the effect of oral administration of BSRGE on brain GABA concentrations compared with commercially available GABA compound and regular feeds. METHODS:Twenty-one male C57BL/6 mice were assigned to BSRGE, a regular feed (AIN-76) lacking GABA, and a regular feed containing GABA compound. After feeding freely for 48 h, the cortex and striatum were separated from the brain. An enzyme-linked immunosorbent assay was conducted to measure GABA and glutamate concentrations in mouse brain. RESULTS:The GABA concentration of the BSRGE group was higher than that of regular feed and GABA compound group (p<0.001). However, the GABA compound group showed no significant difference from the regular feed group (p=0.50). CONCLUSION:Intake of BSRGE containing high GABA content increased GABA concentrations in mouse brain compared with regular feed unlike GABA compound. The results of this study constitute an important basis for further investigations into the clinical applications of BSRGE.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Jung WY,Kim SG,Kim HK,Huh SY,Kim DW,Yoon DU,Yang CH,Kim HY,Jang EY

doi

10.30773/pi.2019.05.13.2

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

615-620

issue

8

eissn

1738-3684

issn

1976-3026

pii

pi.2019.05.13.2

journal_volume

16

pub_type

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