Abstract:
OBJECTIVE:Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study is to elucidate the effect of oral administration of BSRGE on brain GABA concentrations compared with commercially available GABA compound and regular feeds. METHODS:Twenty-one male C57BL/6 mice were assigned to BSRGE, a regular feed (AIN-76) lacking GABA, and a regular feed containing GABA compound. After feeding freely for 48 h, the cortex and striatum were separated from the brain. An enzyme-linked immunosorbent assay was conducted to measure GABA and glutamate concentrations in mouse brain. RESULTS:The GABA concentration of the BSRGE group was higher than that of regular feed and GABA compound group (p<0.001). However, the GABA compound group showed no significant difference from the regular feed group (p=0.50). CONCLUSION:Intake of BSRGE containing high GABA content increased GABA concentrations in mouse brain compared with regular feed unlike GABA compound. The results of this study constitute an important basis for further investigations into the clinical applications of BSRGE.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Jung WY,Kim SG,Kim HK,Huh SY,Kim DW,Yoon DU,Yang CH,Kim HY,Jang EYdoi
10.30773/pi.2019.05.13.2subject
Has Abstractpub_date
2019-08-01 00:00:00pages
615-620issue
8eissn
1738-3684issn
1976-3026pii
pi.2019.05.13.2journal_volume
16pub_type
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journal_title:Psychiatry investigation
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更新日期:2017-03-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2013-12-01 00:00:00
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更新日期:2020-08-01 00:00:00