Prolonged Drug-Drug Interaction between Terbinafine and Perphenazine.

Abstract:

:I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear for 6 weeks, and so at 2 weeks prior to this most recent admission she had stopped taking terbinafine. However, these symptoms persisted for 3 weeks after discontinuing terbinafine. It is well known that terbinafine inhibits CYP2D6 and that perphenazine is metabolized mainly by CYP2D6. Thus, when terbinafine and perphenazine are coadministrated, the subsequent increase in the concentration of perphenazine may induce extrapyramidal symptoms. Thus, terbinafine therapy may be associated with the induction and persistence of extrapyramidal symptoms, including akathisia. This case report emphasizes the importance of monitoring drug-drug interactions in patients undergoing terbinafine and perphenazine therapy.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Park YM

doi

10.4306/pi.2012.9.4.422

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

422-4

issue

4

eissn

1738-3684

issn

1976-3026

journal_volume

9

pub_type

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