Abstract:
OBJECTIVE:The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). METHODS:PubMed and EMBASE databases were searched for structural MRI or amyloid PET imaging studies published between January 2000 and July 2014 that reported conversion to AD in patients with MCI. Means and standard deviations or individual numbers of biomarkers with positive or negative status at baseline and corresponding numbers of patients who had progressed to AD at follow-up were retrieved from each study. The effect size of each biomarker was expressed as Hedges's g. RESULTS:Twenty-four MRI studies and 8 amyloid PET imaging studies were retrieved. 674 of the 1741 participants (39%) developed AD. The effect size for predicting conversion to AD was 0.770 [95% confidence interval (CI) 0.607-0.934] for across MRI and 1.316 (95% CI 0.920-1.412) for amyloid PET imaging (p<0.001). The effect size was 1.256 (95% CI 0.902-1.609) for entorhinal cortex volume from MRI. CONCLUSION:Our study suggests that volumetric MRI measurement may be useful for the early detection of AD.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Seo EH,Park WY,Choo IHdoi
10.4306/pi.2017.14.2.205subject
Has Abstractpub_date
2017-03-01 00:00:00pages
205-215issue
2eissn
1738-3684issn
1976-3026journal_volume
14pub_type
杂志文章abstract:OBJECTIVE:The aim of this study is to investigate whether insight and mentalizing abilities are related to the severity of Obsessive Compulsive Disorder (OCD) in treatment resistant OCD. We look at the association between treatment resistance, insight, and mentalizing ability. METHODS:The study was conducted with 71 O...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.05.02.2
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To examine the reliability and validity of the self-report Korean version of Strengths and Difficulties Questionnaire (SDQ-Kr) in the community sample. METHODS:The SDQ-Kr was administered to a large sample of school children and adolescents (n=2814) and youth attendees of a psychiatric clinic (n=385) aged 11...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.4.491
更新日期:2015-10-01 00:00:00
abstract::While cognitive behavior therapy is considered to be the first-line therapy for adolescent depression, there are limited data on whether other psychotherapeutic techniques are also effective in treating adolescents with depression. This report suggests the potential application of eye movement desensitization and repr...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2008.5.1.60
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:For the proper treatment of first-episode psychosis, assessment of treatment response, remission, relapse, and recovery is important. Therefore, the present study aimed to develop operational definitions of clinical outcomes in first-episode psychosis. METHODS:A questionnaire was developed by a panel of expe...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0240
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the characteristics of psychological factors that are related to irritable bowel syndrome (IBS) and their effects on the quality of life (QOL) of firefighters in South Korea. METHODS:This study examined data collected from 1217 firefighters in South Korea. After i...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.4.434
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:A defense mechanism is an automatic psychological process necessary for successful adaptation. It reflects adaptive capacity. The purpose of this study is to explore the relationship between the adaptation ability of individuals who face mandatory military service and the pattern of defense mechanisms. METHO...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.11.07
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Suicide is a leading cause of death in college age students. Identification of the associated risk factors has important implications for how to prevent and respond to this population; however, few studies have been performed on this topic in this age group. The purpose of this study was to evaluate the preva...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2008.5.2.86
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:We examined a functional model of acquired capability for suicide, which was elaborated from the "Interpersonal-Psychological Theory of Suicide". METHODS:A total of 6,027 Korean community subjects were recruited from The Korean Epidemiologic Catchment Area study conducted in 2011. The subjects were assessed ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.6.601
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Anxiety trait, anxiety and depression states have all been reported to increase risks for cardiovascular disease (CVD), possibly through altering cardiac autonomic regulation. Our aim was to investigate whether the relationship between harm avoidance (HA, an anxiety-related personality trait) and cardiac auto...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.4.397
更新日期:2016-07-01 00:00:00
abstract::Severe physical injury is a leading cause of posttraumatic syndrome (PTS). This is to develop a biomarker-based diagnostic algorithm for posttraumatic syndrome (BioPTS) study. This is a 2-year longitudinal cohort study assessing patients who were hospitalized beginning in 2015 at Chonnam National University Hospital i...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.4.513
更新日期:2017-07-01 00:00:00
abstract: Objective:We utilized a spectral and network analysis technique with an integrated support vector classification algorithm for the automated detection of cognitive capacity using resting state electroencephalogram (EEG) signals. Methods:An eyes-closed resting EEG was recorded in 158 older subjects, and spectral EEG p...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.04.03.1
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The association between benzodiazepine use and the risk of cognitive impairment or dementia has been controversial. Our study aims to detect this association through a case/non-case method using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD) betwee...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0275
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:The Sewol ferry disaster caused shock and grief in South Korea. The aim of this study was to identify the factors associated with symptoms of complicated grief (CG) among the surviving students 20 months after that disaster. METHODS:This study was conducted using a cross-sectional design and a sample of 57 s...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.05.04
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to determine the dose-response relationship between physical activity and anxiety symptoms. METHODS:We included data of 124,434 participants who had comprehensive health-screening examinations from January 1st, 2012, to December 31st, 2016, in Kangbuk Samsung Hospital, Seoul and Suwo...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0078
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:We intended to analyze the credibility judgment in written forensic psychiatric reports of child sexual abuse registered in Southern Taiwan. METHODS:Ninety-six cases of child sexual abuse between August 2010 and October 2017 encountered in two hospitals were analyzed. The. RESULTS:in these reports were cate...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.12.03
更新日期:2019-02-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.5.580
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Serotonin-1A receptors (5-HTR1A) is suggested to be involved in the etiology of several psychiatric disorders including panic disorder (PD). A few imaging studies have suggested the alterations of the cingulum bundle in PD. The objective of this study is to examine the structural changes of cingulum related t...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.4.399
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Seasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Ko...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.09.21
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Continuous performance tests (CPTs) are frequently used in clinical practice to assess the attentiveness of ADHD children. Although most CPTs do not categorize T scores by intelligence, there is great diversity of opinion regarding the interrelation between intelligence and CPT performance. This study aimed t...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2011.8.3.227
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea. ME...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2009.6.4.306
更新日期:2009-12-01 00:00:00
abstract::I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear for 6 weeks, and so at 2 weeks prior to this most recent admission she had stopped taking terbinaf...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.4.422
更新日期:2012-12-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0124
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:This study investigated the treatment response and cognitive enhancement effects of buspirone augmentation of escitalopram in patients with major depressive disorder (MDD), according to atypical feature subtypes of MDD. METHODS:An 8 week, randomized, parallel-controlled, open-label study was conducted. The C...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0017
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:This study aimed to assess the anxiety and depression in patients undergoing hematopoietic stem cell transplantation (HSCT). METHODS:Eighty-seven adult patients with various hematologic diseases, who were scheduled to receive autologous or allogeneic HSCT, were enrolled. The M.D. Anderson Symptom Inventory a...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.07.12
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique increasingly used to relieve symptoms of psychiatric disorders. Electrophysiologic markers, such as electroencephalography (EEG) and event-related potentials (ERP), have high temporal resolution sensitive to detect plas...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.01.10
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS:Twenty one alcohol dependent patients an...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.3.266
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Although specific temperaments have been known to be related to autonomic nervous function in some psychiatric disorders, there are few studies that have examined the relationship between temperaments and autonomic nervous function in a normal population. In this study, we examined the effect of temperament o...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.3.293
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Somatic symptoms in psychiatry include underlying depression, anxiety, or other psychiatric disorders. This study aimed to conduct a validation study of a Korean version of the Somatic Symptom Scale-8 (K-SSS-8), and to utilize the K-SSS-8 effectively in clinical settings. METHODS:For reliabilty, test-retest ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0112
更新日期:2020-08-01 00:00:00
abstract: Objective:To identify attachment insecurity as an associative factor with unresolved psychological distress 1 year after surgery in the early breast cancer (BC) population. Methods:One-hundred fourteen participants completed the Hospital Anxiety and Depression Scale (HADS) and the Experiences in Close Relationship (E...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.06.07
更新日期:2018-08-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.08.11.1
更新日期:2018-09-01 00:00:00