Abstract:
:Bile Salt Export Pump (BSEP) Deficiency disease, including Progressive Familial Intrahepatic Cholestasis type 2 (PFIC2), is a rare disease, usually leading within the first ten years to portal hypertension, liver failure, hepatocellular carcinoma. Often liver transplantation is needed. Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2. Psychiatric side effects in the adolescent population are little known and little studied since the drug used to treat children and infants. So we described a case of Caucasian boy, suffering from a late onset PFIC2, listed for a liver transplant when he was sixteen and treated with 4-FB (200 mg per kilogram of body weight per day). The drug was discontinued for the onset of bipolar and related disorders. This case illustrates possible psychiatric side effects of the drug.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Vitale G,Simonetti G,Pirillo M,Taruschio G,Andreone Pdoi
10.4306/pi.2016.13.5.580subject
Has Abstractpub_date
2016-09-01 00:00:00pages
580-582issue
5eissn
1738-3684issn
1976-3026journal_volume
13pub_type
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journal_title:Psychiatry investigation
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更新日期:2016-09-01 00:00:00
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更新日期:2015-10-01 00:00:00
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更新日期:2013-06-01 00:00:00
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更新日期:2015-07-01 00:00:00
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更新日期:2013-03-01 00:00:00
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更新日期:2018-10-01 00:00:00
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