Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent with Bile Salt Export Pump Deficiency Disease.

Abstract:

:Bile Salt Export Pump (BSEP) Deficiency disease, including Progressive Familial Intrahepatic Cholestasis type 2 (PFIC2), is a rare disease, usually leading within the first ten years to portal hypertension, liver failure, hepatocellular carcinoma. Often liver transplantation is needed. Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2. Psychiatric side effects in the adolescent population are little known and little studied since the drug used to treat children and infants. So we described a case of Caucasian boy, suffering from a late onset PFIC2, listed for a liver transplant when he was sixteen and treated with 4-FB (200 mg per kilogram of body weight per day). The drug was discontinued for the onset of bipolar and related disorders. This case illustrates possible psychiatric side effects of the drug.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Vitale G,Simonetti G,Pirillo M,Taruschio G,Andreone P

doi

10.4306/pi.2016.13.5.580

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

580-582

issue

5

eissn

1738-3684

issn

1976-3026

journal_volume

13

pub_type

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