Abstract:
OBJECTIVE:This study investigated the treatment response and cognitive enhancement effects of buspirone augmentation of escitalopram in patients with major depressive disorder (MDD), according to atypical feature subtypes of MDD. METHODS:An 8 week, randomized, parallel-controlled, open-label study was conducted. The Columbia Atypical Depression Diagnostic Scale was administered to evaluate atypical features. Patients were assigned randomly to the buspirone augmentation or non-buspirone groups. Symptom severity and cognitive function were evaluated using the 17-item Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Beck Depression Inventory, Beck Anxiety Inventory, digit span test, word fluency test, and Trail Making Tests A and B. RESULTS:A total of 89 patients were recruited. There were no significant differences in the measures between the groups; however, among the MDD patients without atypical features, the digit span and word fluency tests were improved by treatment. In the MDD patients without atypical features, the buspirone augmentation group showed a significant improvement on the digit span test compared to the non-buspirone group. CONCLUSION:Buspirone augmentation did not demonstrate significant benefits in MDD patients; however, buspirone augmentation showed greater efficacy for the improvement of cognitive function in MDD patients without atypical features. Our study suggests that atypical features are an important factor for cognitive enhancement in buspirone augmentation treatment in patients with MDD.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Shin C,Ko YH,Shim SH,Kim JS,Na KS,Hahn SW,Lee SHdoi
10.30773/pi.2020.0017subject
Has Abstractpub_date
2020-08-01 00:00:00pages
796-803issue
8eissn
1738-3684issn
1976-3026pii
pi.2020.0017journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:Although the executive function subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) have been used to assess cognitive function in diverse psychiatric illnesses, few studies have verified the validity of this battery for Korean psychiatric patients. Therefore, this preliminary study e...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2014.11.4.394
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Coping can be defined as the reactions to harm or distress individuals take to reduce stress. This study aimed to determine how an individual's temperament and character is correlated with the person's main coping method. METHODS:The Korean version of the Ways of Coping Questionnaire and Temperament and Char...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0084
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:A defense mechanism is an automatic psychological process necessary for successful adaptation. It reflects adaptive capacity. The purpose of this study is to explore the relationship between the adaptation ability of individuals who face mandatory military service and the pattern of defense mechanisms. METHO...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.11.07
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Associations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential co...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2010.7.4.264
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:We aimed to examine the reliability and validity of the Korean Altman Self-Rating Mania Scale (K-ASRM) in a large sample of Korean non-clinical undergraduates. METHODS:Participants (n=1,091) filled out the K-ASRM with other self-report questionnaires assessing bipolarity, mood symptoms and affect. Reliabilit...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.5.562
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:This study assessed the associations of the abnormal brain activation and functional connectivity (FC) during memory processing and brain volume alteration in conjunction with psychiatric symptom severity in patients with obsessive-compulsive disorder (OCD). METHODS:Twenty-OCD patients and 20-healthy control...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0124
更新日期:2020-08-01 00:00:00
abstract::This current study's goal is to summarize the literature regarding Antenatal Depression (AD) in the East Asian countries of Taiwan, China (including Hong Kong and Macau), Japan, and Korea. The main search utilized a Pub med Chinese Electronic Periodical Service (CEPS) literature review using keywords 'AD', and 'Prenat...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.2.111
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Postoperative delirium (POD) is a highly prevalent complex neuropsychiatric syndrome in elderly patients. However, its pathophysiology is currently unknown. Early detection and prevention of POD is important; therefore, the aim of this study was to investigate the link between preoperative insulin growth fact...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.3.327
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The present study aimed to report the initial seizure threshold (IST) of a brief-pulse bilateral electroconvulsive therapy (BP-BL ECT) in Korean patients with schizophrenia/schizoaffective disorder and to identify IST predictors. METHODS:Among 67 patients who received ECT and diagnosed with schizophrenia/sch...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.06.20.2
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:The current study aimed to examine whether specific features of psychomotor retardation (PMR) and cognitive functioning established different profiles in unipolar (UD) and bipolar depression (BD). METHODS:Two groups of age-matched patients with UD (n=54) and BD (n=20) completed the Montgomery-Asberg Depressi...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.0116
更新日期:2019-12-01 00:00:00
abstract::This study investigated the relationship of personality, depression, somatization, anxiety with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the International Prostate Symptom Score (IPSS), 44-item Big Five Inventory (BFI), the Patient He...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.2.268
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to investigate whether insight and mentalizing abilities are related to the severity of Obsessive Compulsive Disorder (OCD) in treatment resistant OCD. We look at the association between treatment resistance, insight, and mentalizing ability. METHODS:The study was conducted with 71 O...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2018.05.02.2
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.3.314
更新日期:2017-05-01 00:00:00
abstract::Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine developed rapidly after starting the medication in a middle-aged male with multiple somatic symptoms and depression. Two days after discontinuation of duloxetine and mana...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.1.83
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. METHODS:In this age- and gender-matched case-control study involving 119 PD pati...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.1.86
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:The Clinical Research Center for Depression (CRESCEND) study is a 9-year observational collaborative prospective cohort study for the clinical outcomes in participants with depressive disorders in Korea. In this study, we examined the baseline characteristics of the depressive participants as the hospital-bas...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2011.8.1.1
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to examine the relationship between substance use and depressive symptoms in a cohort of Koreans aged 45 years and older from a large, population-based study. Using the 2006 Korean Longitudinal Study of Aging, we estimated the prevalence of depressive symptoms and its association ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2014.11.3.272
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:This study aims to provide the information of the stigmas of mental illness such as psychosis, alcoholism, attempt suicide, and depression among North Korean defectors. METHODS:We examined stigma for the mental illnesses of 639 North Korean defectors aged 19 to 65 years who live in the Settlement Support Cen...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.1.9
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impair...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.2.205
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine during neural differentiation at the cellular level, we looked at its effect on protei...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.1.81
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:We investigated whether the addition of Alzheimer's disease-signature region cortical thickness (AD-Ct) and hippocampal volume (Hv) obtained from brain MRI to subjective memory complaints and informant-reports of cognitive decline enhances the screening accuracy for cognitive disorders in a memory clinic sett...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0323
更新日期:2020-09-01 00:00:00
abstract::The concept of pervasive developmental disorders (PDD) and autism spectrum disorders (ASD) closely resemble each other. Both ICD-10 and DSM-IV use the term PDD. The authors surveyed the perception of PDD/ASD and attitudes toward terminology. The subjects of this study were 205 medical/social-welfare professionals work...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2011.8.1.67
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The goal of the present study was to identify the brain mechanism involved in the attribution of person's attitude toward another person, using facial affective pictures and pictures displaying an affectively-loaded situation. METHODS:Twenty four right-handed healthy subjects volunteered for our study. We us...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2010.7.1.31
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0025
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the adolescent brain activation patterns in response to performance feedback (PF), social reward (SR) and monetary reward (MR) and their association with psychological factors. METHODS:Functional magnetic resonance imaging (fMRI) was performed while middle school boys (n=15) p...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2013.10.1.47
更新日期:2013-03-01 00:00:00
abstract::Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer's disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2017.09.20
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2019.05.13.2
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:To examine the reliability and validity of the self-report Korean version of Strengths and Difficulties Questionnaire (SDQ-Kr) in the community sample. METHODS:The SDQ-Kr was administered to a large sample of school children and adolescents (n=2814) and youth attendees of a psychiatric clinic (n=385) aged 11...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.4.491
更新日期:2015-10-01 00:00:00
abstract::I report here an elderly woman receiving perphenazine together with terbinafine. After 1 week of terbinafine treatment she experienced extrapyramidal symptoms and, in particular, akathisia. Her symptoms did not disappear for 6 weeks, and so at 2 weeks prior to this most recent admission she had stopped taking terbinaf...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2012.9.4.422
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:Somatic symptoms in psychiatry include underlying depression, anxiety, or other psychiatric disorders. This study aimed to conduct a validation study of a Korean version of the Somatic Symptom Scale-8 (K-SSS-8), and to utilize the K-SSS-8 effectively in clinical settings. METHODS:For reliabilty, test-retest ...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.30773/pi.2020.0112
更新日期:2020-08-01 00:00:00