Abstract:
OBJECTIVE:Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS:Twenty one alcohol dependent patients and 24 age-matched healthy controls performed a decision-making task during functional MRI. We defined the medial orbitofrontal cortex (mOFC) as a region-of-interest and performed seed-based functional connectivity analysis. RESULTS:Healthy controls were more flexible in adapting an alternative behavioral strategy, which correlated with stronger mOFC-dorsal striatum functional connectivity. In contrast, alcohol dependent patients persisted to the first established behavioral strategy. The mOFC-dorsal striatum functional connectivity was impaired in the alcohol-dependent patients, but increased in correlation with the duration of abstinence. CONCLUSION:Our findings support that the disruption of the mOFC-striatal circuitry contribute to the maldaptive persistent behaviors in alcohol dependent patients.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Lee S,Lee E,Ku J,Yoon KJ,Namkoong K,Jung YCdoi
10.4306/pi.2013.10.3.266subject
Has Abstractpub_date
2013-09-01 00:00:00pages
266-72issue
3eissn
1738-3684issn
1976-3026journal_volume
10pub_type
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00