Abstract:
OBJECTIVE:The association between benzodiazepine use and the risk of cognitive impairment or dementia has been controversial. Our study aims to detect this association through a case/non-case method using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD) between 2007 and 2016. METHODS:Cases were adverse event (AE)-pairs with suspected cognitive impairment or dementia. 10 non-cases were matched to each case on age and sex. Exposure was defined as use of benzodiazepines, including long-, intermediate-, and short-acting benzodiazepine. We conducted multivariable logistic regression analyses to estimate reporting odds ratios (ROR) and 95% confidence intervals (CI). RESULTS:Of the 1,086,584 AE-pairs, 887 cases were suspected AE-pairs of cognitive impairment or dementia, and 775,444 non-cases were selected. Benzodiazepine use was associated with increased AE-pairs of cognitive impairment or dementia when assessed using those with certain, probable, and/or possible in causality assessments (ROR=2.69, 95% CI=1.66-4.38). Higher ROR estimates were shown in female (2.33, 1.48-3.67) and in those with polypharmacy (2.20, 1.35-3.57). Dementia safety profiles were inconsistent across individual benzodiazepine components. CONCLUSION:These results suggest the potentially increased association between benzodiazepine use and cognitive impairment or dementia in female and those with polypharmacy. Inconsistent safety profiles of benzodiazepine components should be further investigated.
journal_name
Psychiatry Investigjournal_title
Psychiatry investigationauthors
Baek YH,Kim HJ,Bae JH,Lee H,Oh IS,Kim WJ,Shin JYdoi
10.30773/pi.2019.0275subject
Has Abstractpub_date
2020-06-01 00:00:00pages
587-595issue
6eissn
1738-3684issn
1976-3026pii
pi.2019.0275journal_volume
17pub_type
杂志文章abstract:OBJECTIVE:The Revised Obsessive Intrusion Inventory (ROII) is a 52-item scale that evaluates obsessional intrusive thoughts. The aim of the present study was to validate a short, 20-item Korean version of the ROII (ROII-20). METHODS:Of the 1125 participants who completed the ROII-20, 895 participants completed the sca...
journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2015.12.3.288
更新日期:2015-07-01 00:00:00
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journal_title:Psychiatry investigation
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journal_title:Psychiatry investigation
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doi:10.4306/pi.2009.6.3.156
更新日期:2009-09-01 00:00:00
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journal_title:Psychiatry investigation
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doi:10.4306/pi.2015.12.4.491
更新日期:2015-10-01 00:00:00
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doi:10.30773/pi.2019.02.26.2
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2016.13.2.196
更新日期:2016-03-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Psychiatry investigation
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更新日期:2011-03-01 00:00:00
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journal_title:Psychiatry investigation
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doi:10.4306/pi.2012.9.3.223
更新日期:2012-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
doi:10.4306/pi.2017.14.2.136
更新日期:2017-03-01 00:00:00
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journal_title:Psychiatry investigation
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doi:10.4306/pi.2017.14.4.513
更新日期:2017-07-01 00:00:00
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doi:10.4306/pi.2017.14.6.770
更新日期:2017-11-01 00:00:00
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doi:10.4306/pi.2017.14.6.844
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.30773/pi.2020.0323
更新日期:2020-09-01 00:00:00
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更新日期:2015-04-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2016-09-01 00:00:00
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journal_title:Psychiatry investigation
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Psychiatry investigation
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00