Treatment with selective serotonin reuptake inhibitors and mirtapazine results in differential brain activation by visual erotic stimuli in patients with major depressive disorder.

Abstract:

OBJECTIVE:The objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors (SSRIs) or mirtazipine. METHODS:Nine middle-aged men with major depressive disorder treated with an SSRI and ten middle-aged men with major depressive disorder treated with mirtazapine completed the trial. Ten subjects with no psychiatric illness were included as a control group. We conducted functional brain magnetic resonance imaging (fMRI) while a film alternatively played erotic and non-erotic contents for 14 minutes and 9 seconds. RESULTS:The control group showed activation in the occipitotemporal area, anterior cingulate gyrus, insula, orbitofrontal cortex, and caudate nucleus. For subjects treated with SSRIs, the intensity of activity in these regions was much lower compared to the control group. Intensity of activation in the group treated with mirtazapine was less than the control group but grea-ter than those treated with SSRIs. Using subtraction analysis, the SSRI group showed significantly lower activation than the mirtazapine group in the anterior cingulate gyrus and the caudate nucleus. CONCLUSION:Our study suggests that the different rates of sexual side effects between the patients in the SSRI-treated group and the mirtazapine-treated group may be due to different effects on brain activation.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Kim W,Jin BR,Yang WS,Lee KU,Juh RH,Ahn KJ,Chung YA,Chae JH

doi

10.4306/pi.2009.6.2.85

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

85-95

issue

2

eissn

1738-3684

issn

1976-3026

journal_volume

6

pub_type

杂志文章
  • Deficit in decision-making in chronic, stable schizophrenia: from a reward and punishment perspective.

    abstract:OBJECTIVE:We compared patients with chronic schizophrenia and normal controls with respect to decision-making ability. Measures were implemented to control for the participants' intelligence levels as well as to ensure to use of a moderate sample size. The goal of this study was to confirm inconsistent results from pre...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2009.6.1.26

    authors: Kim YT,Lee KU,Lee SJ

    更新日期:2009-03-01 00:00:00

  • Efficacy of Buspirone Augmentation of Escitalopram in Patients with Major Depressive Disorder with and without Atypical Features: A Randomized, 8 Week, Multicenter, Open-Label Clinical Trial.

    abstract:OBJECTIVE:This study investigated the treatment response and cognitive enhancement effects of buspirone augmentation of escitalopram in patients with major depressive disorder (MDD), according to atypical feature subtypes of MDD. METHODS:An 8 week, randomized, parallel-controlled, open-label study was conducted. The C...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2020.0017

    authors: Shin C,Ko YH,Shim SH,Kim JS,Na KS,Hahn SW,Lee SH

    更新日期:2020-08-01 00:00:00

  • Anger-Related Characteristics According to Chronotypes in Bipolar or Depressive Disorders.

    abstract:OBJECTIVE:Though anger was highly associated with eveningness in general population, there is no study on the relationship between chronotype and anger-related characteristics in bipolar or depressive disorders. This study aimed to investigate the difference of anger-related characteristics according to chronotypes in ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.0326

    authors: Kang TU,Moon E,Choi Y,Suh H,Park JM,Lee BD,Lee YM,Jeong HJ,Kim SY,Lee K,Lim HJ,Yoon M

    更新日期:2020-09-01 00:00:00

  • The Relationship of Clinical Symptoms with Social Cognition in Children Diagnosed with Attention Deficit Hyperactivity Disorder, Specific Learning Disorder or Autism Spectrum Disorder.

    abstract:OBJECTIVE:One of the areas of social cognition is Theory of Mind (ToM) is defined as the capacity to interpret, infer and explain mental states underlying the behavior of others. When social cognition studies on neurodevelopmental disorders are examined, it can be seen that this skill has not been studied sufficiently ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.10.01

    authors: Şahin B,Karabekiroğlu K,Bozkurt A,Usta MB,Aydın M,Çobanoğlu C

    更新日期:2018-12-01 00:00:00

  • Serum homocysteine and folate levels in korean schizophrenic patients.

    abstract:OBJECTIVE:This study was conducted to confirm the results of the authors' previous research on schizophrenia manifesting high serum homocysteine and low folate levels. This study is anchored on a theory that a high serum homocysteine concentration affects schizophrenia by virtue of a neurotoxic mechanism, and on a repo...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2011.8.2.134

    authors: Kim TH,Moon SW

    更新日期:2011-06-01 00:00:00

  • Eye movement desensitization and reprocessing for adolescent depression.

    abstract::While cognitive behavior therapy is considered to be the first-line therapy for adolescent depression, there are limited data on whether other psychotherapeutic techniques are also effective in treating adolescents with depression. This report suggests the potential application of eye movement desensitization and repr...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2008.5.1.60

    authors: Bae H,Kim D,Park YC

    更新日期:2008-03-01 00:00:00

  • Shape Deformation in the Brainstem of Medication-Naïve Female Patients with Major Depressive Disorder.

    abstract:OBJECTIVE:Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2020.0025

    authors: Choi KW,Kwon S,Pyun SB,Tae WS

    更新日期:2020-05-01 00:00:00

  • Use of the terms "schizophrenia" and "schizophrenic" in the South Korean news media: a content analysis of newspapers and news programs in the last 10 years.

    abstract:OBJECTIVE:In this study, we explored the meaning attributed to the words "jungshinbunyeolbyung" (schizophrenia) and "jungshinbunyeol" (schizophrenic) in South Korean newspapers and news programs in the last 10 years. METHODS:We screened the websites of three national newspapers and the broadcasts of three nationwide t...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2012.9.1.17

    authors: Park JH,Choi YM,Kim B,Lee DW,Gim MS

    更新日期:2012-03-01 00:00:00

  • The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations.

    abstract:OBJECTIVE:Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.05.13.2

    authors: Jung WY,Kim SG,Kim HK,Huh SY,Kim DW,Yoon DU,Yang CH,Kim HY,Jang EY

    更新日期:2019-08-01 00:00:00

  • Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression.

    abstract::Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.5.708

    authors: Lee K,Han JW,Kim KW

    更新日期:2017-09-01 00:00:00

  • Treatment-Resistant Depression Entering Remission Following a Seizure during the Course of Repetitive Transcranial Magnetic Stimulation.

    abstract::Major depressive disorder is often resistant to antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) has been used in treatment-resistant depression (TRD). Known adverse events of rTMS include transient headache, local pain, syncope, seizure induction, and hypomania induction. This report outl...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2016.13.4.468

    authors: Kim JW,Bae KY,Kim SW,Kang HJ,Shin IS,Yoon JS,Kim JM

    更新日期:2016-07-01 00:00:00

  • Associations of Temperament and Character with Coping Strategies among Office Workers.

    abstract:OBJECTIVE:Coping can be defined as the reactions to harm or distress individuals take to reduce stress. This study aimed to determine how an individual's temperament and character is correlated with the person's main coping method. METHODS:The Korean version of the Ways of Coping Questionnaire and Temperament and Char...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.0084

    authors: Hwang HC,Kim SM,Han DH,Min KJ

    更新日期:2020-01-01 00:00:00

  • Initial Psychometric Properties of the Korean Altman Self-Rating Mania Scale: Preliminary Validation Study in a Non-Clinical Sample.

    abstract:OBJECTIVE:We aimed to examine the reliability and validity of the Korean Altman Self-Rating Mania Scale (K-ASRM) in a large sample of Korean non-clinical undergraduates. METHODS:Participants (n=1,091) filled out the K-ASRM with other self-report questionnaires assessing bipolarity, mood symptoms and affect. Reliabilit...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.5.562

    authors: Kim BN,Kwon SM

    更新日期:2017-09-01 00:00:00

  • Disruption of orbitofronto-striatal functional connectivity underlies maladaptive persistent behaviors in alcohol-dependent patients.

    abstract:OBJECTIVE:Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS:Twenty one alcohol dependent patients an...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2013.10.3.266

    authors: Lee S,Lee E,Ku J,Yoon KJ,Namkoong K,Jung YC

    更新日期:2013-09-01 00:00:00

  • Application of Assessment Tools to Examine Mental Health in Workplaces: Job Stress and Depression.

    abstract::Despite the fact that the lifetime and yearly prevalence rates of mental illness continue rising, such diseases have only been acknowledged as involved in workplace health issue since the 2000s. Additionally, while the number of recognized cases of mental illnesses is rather low compared to their prevalence, they have...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2016.10.24

    authors: Jeon SW,Kim YK

    更新日期:2018-06-01 00:00:00

  • Factors Associated with Complicated Grief in Students Who Survived the Sewol Ferry Disaster in South Korea.

    abstract:OBJECTIVE:The Sewol ferry disaster caused shock and grief in South Korea. The aim of this study was to identify the factors associated with symptoms of complicated grief (CG) among the surviving students 20 months after that disaster. METHODS:This study was conducted using a cross-sectional design and a sample of 57 s...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2017.05.04

    authors: Lee SH,Nam HS,Kim HB,Kim EJ,Noh JW,Chae JH

    更新日期:2018-03-01 00:00:00

  • Structural MRI and Amyloid PET Imaging for Prediction of Conversion to Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Meta-Analysis.

    abstract:OBJECTIVE:The aim of this study was to explore the prognostic values of biomarkers of neurodegeneration as measured by magnetic resonance imaging (MRI) and amyloid burden as measured by amyloid positron emission tomography (PET) in predicting conversion to Alzheimer's disease (AD) in patients with mild cognitive impair...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.2.205

    authors: Seo EH,Park WY,Choo IH

    更新日期:2017-03-01 00:00:00

  • Combined Measures of Psychomotor and Cognitive Alterations as a Potential Hallmark for Bipolar Depression.

    abstract:OBJECTIVE:The current study aimed to examine whether specific features of psychomotor retardation (PMR) and cognitive functioning established different profiles in unipolar (UD) and bipolar depression (BD). METHODS:Two groups of age-matched patients with UD (n=54) and BD (n=20) completed the Montgomery-Asberg Depressi...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.0116

    authors: Robin A,Sauvaget A,Deschamps T,Bulteau S,Thomas-Ollivier V

    更新日期:2019-12-01 00:00:00

  • Psychometric Properties of a Short Korean Version of the Revised Obsessive Intrusion Inventory.

    abstract:OBJECTIVE:The Revised Obsessive Intrusion Inventory (ROII) is a 52-item scale that evaluates obsessional intrusive thoughts. The aim of the present study was to validate a short, 20-item Korean version of the ROII (ROII-20). METHODS:Of the 1125 participants who completed the ROII-20, 895 participants completed the sca...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.3.288

    authors: Seo JW,Baek MJ,Lee MS,Jeon JR,Kwon SM

    更新日期:2015-07-01 00:00:00

  • Relations between Stress and Quality of Life among Women in Late Pregnancy: The Parallel Mediating Role of Depressive Symptoms and Sleep Quality.

    abstract:OBJECTIVE:This study aims to examine the parallel multiple mediators of depressive symptoms and sleep quality in the relations between stress and physical health-related quality of life (PHQOL)/mental health-related quality of life (MHQOL) among the women in late pregnancy. METHODS:Of 1120 pregnant women participated ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.02.14

    authors: Zhang H,Zhang Q,Gao T,Kong Y,Qin Z,Hu Y,Cao R,Mei S

    更新日期:2019-05-01 00:00:00

  • Distinguishing Quantitative Electroencephalogram Findings between Adjustment Disorder and Major Depressive Disorder.

    abstract:OBJECTIVE:Adjustment disorder (ADJ) is a common diagnosis. However, it is difficult to distinguish ADJ from other major Axis I disorders, such as major depressive disorder (MDD). The aim of this study was to determine the distinguishing neurophysiological characteristics between ADJ and MDD using quantitative analysis ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2013.10.1.62

    authors: Jeong HG,Ko YH,Han C,Kim YK,Joe SH

    更新日期:2013-03-01 00:00:00

  • The Relationship between Depression, Anxiety, Somatization, Personality and Symptoms of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia.

    abstract::This study investigated the relationship of personality, depression, somatization, anxiety with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH). The LUTS/BPH patients were evaluated with the International Prostate Symptom Score (IPSS), 44-item Big Five Inventory (BFI), the Patient He...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.2.268

    authors: Koh JS,Ko HJ,Wang SM,Cho KJ,Kim JC,Lee SJ,Pae CU

    更新日期:2015-04-01 00:00:00

  • Evaluation of a Functional Model of Acquired Capability for Suicide in a Nationwide Sample of Korean Adults.

    abstract:OBJECTIVE:We examined a functional model of acquired capability for suicide, which was elaborated from the "Interpersonal-Psychological Theory of Suicide". METHODS:A total of 6,027 Korean community subjects were recruited from The Korean Epidemiologic Catchment Area study conducted in 2011. The subjects were assessed ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2016.13.6.601

    authors: Lee JD,Cho MJ,Sohn JH,Park S,Seong S,Ahn JH,Hahm BJ,Hong JP

    更新日期:2016-11-01 00:00:00

  • Impact of Mindfulness-Based Cognitive Therapy on Intolerance of Uncertainty in Patients with Panic Disorder.

    abstract:OBJECTIVE:Intolerance of uncertainty (IU) is a transdiagnostic construct in various anxiety and depressive disorders. However, the relationship between IU and panic symptom severity is not yet fully understood. We examined the relationship between IU, panic, and depressive symptoms during mindfulness-based cognitive th...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2016.13.2.196

    authors: Kim MK,Lee KS,Kim B,Choi TK,Lee SH

    更新日期:2016-03-01 00:00:00

  • Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.

    abstract:OBJECTIVE:Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea. ME...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2009.6.4.306

    authors: Na KS,Tae SH,Song JW,Kim YK

    更新日期:2009-12-01 00:00:00

  • A preliminary validity study of the cambridge neuropsychological test automated battery for the assessment of executive function in schizophrenia and bipolar disorder.

    abstract:OBJECTIVE:Although the executive function subtests of the Cambridge Neuropsychological Test Automated Battery (CANTAB) have been used to assess cognitive function in diverse psychiatric illnesses, few studies have verified the validity of this battery for Korean psychiatric patients. Therefore, this preliminary study e...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2014.11.4.394

    authors: Kim HS,An YM,Kwon JS,Shin MS

    更新日期:2014-10-01 00:00:00

  • The impact of executive function on emotion recognition and emotion experience in patients with schizophrenia.

    abstract:OBJECTIVE:This study investigated the impact of executive function on the performance of two different affective tasks, the Facial Affect Identification Task (FAIT) and the Iowa Gambling Task (IGT), in patients with schizophrenia. METHODS:Thirty-nine patients with schizophrenia and 33 healthy controls completed the FA...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2009.6.3.156

    authors: Lee SJ,Lee HK,Kweon YS,Lee CT,Lee KU

    更新日期:2009-09-01 00:00:00

  • Can Residual Symptoms During Inter-Episode Period after Partial Remission in Bipolar I Disorder Have Cyclic Patterns with Specific Frequencies?

    abstract::This case report aimed to describe cyclic patterns of residual mood symptoms in partially remitted bipolar I patient. In a 24-year-old woman with bipolar I disorder, residual mood symptoms measured by self-rated daily mood chart for 18 months were analyzed using wavelet analysis. A 146-day periodicity was prominent fo...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2017.08.23

    authors: Cheon Y,Moon E,Park JM,Lee BD,Lee YM,Jeong HJ,Kang TU,Park J,Choi Y

    更新日期:2018-03-01 00:00:00

  • The clinical research center for depression study: baseline characteristics of a korean long-term hospital-based observational collaborative prospective cohort study.

    abstract:OBJECTIVE:The Clinical Research Center for Depression (CRESCEND) study is a 9-year observational collaborative prospective cohort study for the clinical outcomes in participants with depressive disorders in Korea. In this study, we examined the baseline characteristics of the depressive participants as the hospital-bas...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2011.8.1.1

    authors: Kim TS,Jeong SH,Kim JB,Lee MS,Kim JM,Yim HW,Jun TY

    更新日期:2011-03-01 00:00:00

  • Modulation of Electrophysiology by Transcranial Direct Current Stimulation in Psychiatric Disorders: A Systematic Review.

    abstract:OBJECTIVE:Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique increasingly used to relieve symptoms of psychiatric disorders. Electrophysiologic markers, such as electroencephalography (EEG) and event-related potentials (ERP), have high temporal resolution sensitive to detect plas...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.01.10

    authors: Kim M,Kwak YB,Lee TY,Kwon JS

    更新日期:2018-05-01 00:00:00