Rapid-onset hyponatremia induced by duloxetine in a middle-aged male with depression and somatic symptoms.

Abstract:

:Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine developed rapidly after starting the medication in a middle-aged male with multiple somatic symptoms and depression. Two days after discontinuation of duloxetine and management with hypertonic saline as well as fluid restriction, the serum sodium level normalized. The patient had two risk factors for developing hyponatremia, such as severe body weight loss and pneumonia. Therefore, when treating patients with depression and somatic symptoms, especially with risk factors for developing hyponatremia, close monitoring for clinical and laboratory evidence of hyponatremia may be essential.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Choi JS,Lee HW,Lee JY,Jung HY

doi

10.4306/pi.2012.9.1.83

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

83-4

issue

1

eissn

1738-3684

issn

1976-3026

journal_volume

9

pub_type

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