The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study.

Abstract:

OBJECTIVE:Electrophysiological studies, which are mostly focused on afferent pathway, have proven that auditory processing deficits exist in patients with schizophrenia. Nevertheless, reports on the suppressive effect of efferent auditory pathway on cochlear outer hair cells among schizophrenia patients are limited. The present, case-control, study examined the contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) in patients with schizophrenia. METHODS:Participants were twenty-three healthy controls and sixteen schizophrenia patients with normal hearing, middle ear and cochlear outer hair cells function. Absolute non-linear and linear TEOAEs were measured in both ears by delivering clicks stimuli at 80 dB SPL and 60 dB SPL respectively. Subsequently, contralateral suppression was determined by subtracting the absolute TEOAEs response obtained at 60 dBpe SPL during the absence and presence of contralateral white noise delivered at 65 dB HL. No attention tasks were conducted during measurements. RESULTS:We found no significant difference in absolute TEOAEs responses at 80 dB SPL, in either diagnosis or ear groups (p>0.05). However, the overall contralateral suppression was significantly larger in schizophrenia patients (p<0.05). Specifically, patients with schizophrenia demonstrated significantly increased right ear contralateral suppression compared to healthy control (p<0.05). CONCLUSION:The present findings suggest increased inhibitory effect of efferent auditory pathway especially on the right cochlear outer hair cells. Further studies to investigate increased suppressive effects are crucial to expand the current understanding of auditory hallucination mechanisms in schizophrenia patients.

journal_name

Psychiatry Investig

journal_title

Psychiatry investigation

authors

Abdul Wahab NA,Wahab S,Abdul Rahman AH,Sidek D,Zakaria MN

doi

10.4306/pi.2016.13.1.82

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

82-8

issue

1

eissn

1738-3684

issn

1976-3026

journal_volume

13

pub_type

杂志文章
  • Treatment with selective serotonin reuptake inhibitors and mirtapazine results in differential brain activation by visual erotic stimuli in patients with major depressive disorder.

    abstract:OBJECTIVE:The objective of this study was to identify patterns of brain activation elicited by erotic visual stimuli in patients treated with either Selective Serotonin Reuptake Inhibitors (SSRIs) or mirtazipine. METHODS:Nine middle-aged men with major depressive disorder treated with an SSRI and ten middle-aged men w...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2009.6.2.85

    authors: Kim W,Jin BR,Yang WS,Lee KU,Juh RH,Ahn KJ,Chung YA,Chae JH

    更新日期:2009-06-01 00:00:00

  • Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C.

    abstract:OBJECTIVE:The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.3.314

    authors: Choi JS,Kim W,Sohn BK,Lee JY,Jung HY,Oh S,Joo SK,Kim HY,Jung YJ

    更新日期:2017-05-01 00:00:00

  • Serum homocysteine and folate levels in korean schizophrenic patients.

    abstract:OBJECTIVE:This study was conducted to confirm the results of the authors' previous research on schizophrenia manifesting high serum homocysteine and low folate levels. This study is anchored on a theory that a high serum homocysteine concentration affects schizophrenia by virtue of a neurotoxic mechanism, and on a repo...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2011.8.2.134

    authors: Kim TH,Moon SW

    更新日期:2011-06-01 00:00:00

  • Validation of the Korean Version of the Delirium Motor Subtype Scale.

    abstract:Objective:The Delirium Motor Subtype Scale (DMSS) is a validated and reliable instrument developed from various methods previously used to assess delirium motor subtypes. It focuses on pure motor disturbances with a relative specificity for delirium. The aim of this study was to investigate the validity and reliability...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2018.15.1.6

    authors: Kim H,Lee M,Kwon IS,Kim JL

    更新日期:2018-01-01 00:00:00

  • Psychometric Properties of a Short Korean Version of the Revised Obsessive Intrusion Inventory.

    abstract:OBJECTIVE:The Revised Obsessive Intrusion Inventory (ROII) is a 52-item scale that evaluates obsessional intrusive thoughts. The aim of the present study was to validate a short, 20-item Korean version of the ROII (ROII-20). METHODS:Of the 1125 participants who completed the ROII-20, 895 participants completed the sca...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.3.288

    authors: Seo JW,Baek MJ,Lee MS,Jeon JR,Kwon SM

    更新日期:2015-07-01 00:00:00

  • Standardization Study of the Korean Version of the Stages of Change Readiness and Treatment Eagerness Scale for Smoking Cessation (K-SOCRATES-S) and Its Predictive Validity.

    abstract:OBJECTIVE:The purpose of the study was to develop the Korean version of the Stage of Change Readiness and Treatment Eagerness Scale for Smoking Cessation (K-SOCRATES-S) based on the Korean version of the Stages of Readiness for Change and Eagerness for Treatment scale (K-SOCRATES). This paper also demonstrates its reli...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2012.9.3.223

    authors: Park JW,Park KH,Joe KH,Choi SH,Lee IJ,Hwang JH,Kwon M,Wang SM,Kim DJ

    更新日期:2012-09-01 00:00:00

  • The Symptom Frequency Characteristics of the Hamilton Depression Rating Scale and Possible Symptom Clusters of Depressive Disorders in Korea: The CRESCEND Study.

    abstract:OBJECTIVE:This study analyzed the symptom frequencies of 17-item Hamilton Depression Rating Scale (HDRS-17) to understand the characteristics of each item and to propose the possible symptoms clusters. METHODS:From psychiatric clinics of 18 Hospitals in Korea, 1,183 patients, diagnosed with major depressive disorder (...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2011.8.4.312

    authors: Jang SH,Park YN,Jae YM,Jun TY,Lee MS,Kim JM,Jeong SH,Kim JB

    更新日期:2011-12-01 00:00:00

  • Factors associated with caregiver burden in patients with Alzheimer's disease.

    abstract:OBJECTIVE:Caregivers for patients with Alzheimer's disease (AD) suffer from psychological and financial burdens. However, the results of the relationship between burden and cognitive function, performance of activities of daily living, and depressive symptoms have remained inconsistent. Therefore, the aim of this study...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2014.11.2.152

    authors: Kang HS,Myung W,Na DL,Kim SY,Lee JH,Han SH,Choi SH,Kim S,Kim S,Kim DK

    更新日期:2014-04-01 00:00:00

  • Traumatic experiences and mental health of north korean refugees in South Korea.

    abstract:OBJECTIVE:This study was conducted at Hanawon-a government sponsored educational facility for the settlement of North Korean refugees during their initial phase in South Korea-in 2004 to explore their mental health status and traumatic experiences in North Korea and during their escape period. METHODS:A survey was con...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2008.5.4.213

    authors: Jeon WT,Yu SE,Cho YA,Eom JS

    更新日期:2008-12-01 00:00:00

  • The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations.

    abstract:OBJECTIVE:Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.05.13.2

    authors: Jung WY,Kim SG,Kim HK,Huh SY,Kim DW,Yoon DU,Yang CH,Kim HY,Jang EY

    更新日期:2019-08-01 00:00:00

  • The temperament and character of korean male conscripts with military maladjustment-a preliminary study.

    abstract:OBJECTIVE:Recently, an increasing number of Korean male conscripts have been retiring because of military maladjustment despite the presence of qualifying medical and psychological screening tests in the Korean army. These problems suggest the presence of a common personality problem. To further examine this possibilit...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2013.10.2.131

    authors: Han KH,Lee SB

    更新日期:2013-06-01 00:00:00

  • Regional Beta Index of Electroencephalography May Differentiate Alzheimer's Disease from Depression.

    abstract::Differentiating early Alzheimer's disease (AD) from depression with cognitive impairment is challenging in the elderly. To develop a model for differentiating these two conditions using electroencephalography (EEG), we enrolled 11 patients with early probable AD and 11 age- and cognitive function-matched patients with...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.5.708

    authors: Lee K,Han JW,Kim KW

    更新日期:2017-09-01 00:00:00

  • The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms.

    abstract:OBJECTIVE:The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship betwe...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.08.31

    authors: Oh KS,Kim EJ,Ha JW,Woo HY,Kwon MJ,Shin DW,Shin YC,Lim SW

    更新日期:2018-11-01 00:00:00

  • The Economic Crisis in Greece and Its Impact on the Seasonality of Suicides in the Athens Greater Area.

    abstract:OBJECTIVE:The economic crisis and the implementation of austerity measures in Greece lead to significant socioeconomic changes. The effects of the crisis were mainly felt by the Greek population during the years 2011 and 2012. This study aimed to investigate the impact of Greece's economic crisis on the seasonality of ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.1.16

    authors: Christodoulou C,Efstathiou V,Michopoulos I,Gkerekou M,Paraschakis A,Koutsaftis F,Douzenis A

    更新日期:2017-01-01 00:00:00

  • Profiling of Proteins Regulated by Venlafaxine during Neural Differentiation of Human Cells.

    abstract:OBJECTIVE:Antidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine during neural differentiation at the cellular level, we looked at its effect on protei...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.1.81

    authors: Doh MS,Han DM,Oh DH,Kim SH,Choi MR,Chai YG

    更新日期:2015-01-01 00:00:00

  • Relationship between Delusion of Theft and Cognitive Functions in Patients with Mild Alzheimer's Disease.

    abstract::Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer's disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2017.09.20

    authors: Na HR,Kang DW,Woo YS,Bahk WM,Lee CU,Lim HK

    更新日期:2018-04-01 00:00:00

  • The predictors of parent reported behaviors related to olfactory information processing in children with ADHD.

    abstract:OBJECTIVE:Attention deficit hyperactivity disorder (ADHD) is a heterogeneous disorder with contradictory findings about smell detection function. It is not clear if the parent perceived behavior related to olfactory function is associated with age, gender, severity of ADHD, and cooccurring symptoms of anxiety and oppos...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2010.7.2.116

    authors: Ghanizadeh A

    更新日期:2010-06-01 00:00:00

  • Initial Psychometric Properties of the Korean Altman Self-Rating Mania Scale: Preliminary Validation Study in a Non-Clinical Sample.

    abstract:OBJECTIVE:We aimed to examine the reliability and validity of the Korean Altman Self-Rating Mania Scale (K-ASRM) in a large sample of Korean non-clinical undergraduates. METHODS:Participants (n=1,091) filled out the K-ASRM with other self-report questionnaires assessing bipolarity, mood symptoms and affect. Reliabilit...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2017.14.5.562

    authors: Kim BN,Kwon SM

    更新日期:2017-09-01 00:00:00

  • Treatment-Resistant Depression Entering Remission Following a Seizure during the Course of Repetitive Transcranial Magnetic Stimulation.

    abstract::Major depressive disorder is often resistant to antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) has been used in treatment-resistant depression (TRD). Known adverse events of rTMS include transient headache, local pain, syncope, seizure induction, and hypomania induction. This report outl...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2016.13.4.468

    authors: Kim JW,Bae KY,Kim SW,Kang HJ,Shin IS,Yoon JS,Kim JM

    更新日期:2016-07-01 00:00:00

  • Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention Deficit Hyperactivity Disorder.

    abstract:OBJECTIVE:Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD). METHOD...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.3.361

    authors: Kul M,Unal F,Kandemir H,Sarkarati B,Kilinc K,Kandemir SB

    更新日期:2015-07-01 00:00:00

  • Regional Quantitative Magnetic Resonance Imaging Data Improve Screening Accuracy of Subjective Memory Complaints and Informant Reports of Cognitive Decline.

    abstract:OBJECTIVE:We investigated whether the addition of Alzheimer's disease-signature region cortical thickness (AD-Ct) and hippocampal volume (Hv) obtained from brain MRI to subjective memory complaints and informant-reports of cognitive decline enhances the screening accuracy for cognitive disorders in a memory clinic sett...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2020.0323

    authors: Yim SJ,Yi D,Byun MS,Sung K,Lee DY

    更新日期:2020-09-01 00:00:00

  • Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects.

    abstract:OBJECTIVE:Autistic spectrum traits are postulated to lie on a continuum that extends between individuals with autism and individuals with typical development. The present study was carried out to investigate functional and network abnormalities associated with autistic spectrum trait in healthy male subjects. METHODS:...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.07.27

    authors: Ota M,Matsuo J,Sato N,Teraishi T,Hori H,Hattori K,Kamio Y,Maikusa N,Matsuda H,Kunugi H

    更新日期:2018-10-01 00:00:00

  • Generalized anxiety disorder, comorbid major depression and heart rate variability: a case-control study in taiwan.

    abstract:OBJECTIVE:Decreased heart rate variability (HRV) has been reported in generalized anxiety disorder (GAD), but the results are mixed. Little is known about the impact of comorbid major depression (MD) on HRV in GAD patients. Both issues necessitate further investigation. METHODS:Twenty unmedicated, physically healthy G...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2013.10.4.326

    authors: Chang HA,Chang CC,Tzeng NS,Kuo TB,Lu RB,Huang SY

    更新日期:2013-12-01 00:00:00

  • The clinical research center for depression study: baseline characteristics of a korean long-term hospital-based observational collaborative prospective cohort study.

    abstract:OBJECTIVE:The Clinical Research Center for Depression (CRESCEND) study is a 9-year observational collaborative prospective cohort study for the clinical outcomes in participants with depressive disorders in Korea. In this study, we examined the baseline characteristics of the depressive participants as the hospital-bas...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2011.8.1.1

    authors: Kim TS,Jeong SH,Kim JB,Lee MS,Kim JM,Yim HW,Jun TY

    更新日期:2011-03-01 00:00:00

  • Factor Analysis of Delirium in Elderly, Using the Korean Version of Delirium Rating Scale-Revised-98.

    abstract:OBJECTIVE:This study aimed to identify the core symptoms of delirium, particularly in elderly people associated with major risk factors, using the Korean version of the Delirium Rating Scale-Revised-98. METHODS:The study sample consisted of 200 patients (mean age: 72.7±3.9 years, male: 68.5%) who had been diagnosed wi...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2017.10.06

    authors: Noh G,Kwon I,Lee M,Ahn SH,Kim JL

    更新日期:2018-05-01 00:00:00

  • Peripheral Biomarkers for First-Episode Psychosis-Opportunities from the Neuroinflammatory Hypothesis of Schizophrenia.

    abstract:OBJECTIVE:Schizophrenia is a disabling disorder of unknown aetiology, lacking definite diagnostic method and cure. A reliable biological marker of schizophrenia is highly demanded, for which traceable immune mediators in blood could be promising candidates. We aimed to gather the best findings of neuroinflammatory mark...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.12.19.1

    authors: Trovão N,Prata J,VonDoellinger O,Santos S,Barbosa M,Coelho R

    更新日期:2019-03-01 00:00:00

  • Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.

    abstract:OBJECTIVE:Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea. ME...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2009.6.4.306

    authors: Na KS,Tae SH,Song JW,Kim YK

    更新日期:2009-12-01 00:00:00

  • White Matter Tract-Cognitive Relationships in Children with High-Functioning Autism Spectrum Disorder.

    abstract:OBJECTIVE:The purpose of the present study was to clarify the relationship between white matter tracts and cognitive symptoms in children with high-functioning autism spectrum disorder (ASD). METHODS:We examined the cognitive functions of 17 children with high-functioning ASD and 18 typically developing (TD) controls ...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2019.01.16

    authors: Kato Y,Kagitani-Shimono K,Matsuzaki J,Hanaie R,Yamamoto T,Tominaga K,Watanabe Y,Mohri I,Taniike M

    更新日期:2019-03-01 00:00:00

  • Mature Defense Mechanisms Affect Successful Adjustment in Young Adulthood-Adjustment to Military Service in South Korea.

    abstract:OBJECTIVE:A defense mechanism is an automatic psychological process necessary for successful adaptation. It reflects adaptive capacity. The purpose of this study is to explore the relationship between the adaptation ability of individuals who face mandatory military service and the pattern of defense mechanisms. METHO...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.30773/pi.2018.11.07

    authors: Nam JW,Ha JH,Choi E,Park DH,Ryu SH

    更新日期:2019-07-01 00:00:00

  • New-onset mania following bariatric surgery.

    abstract::Obesity has become a major public health problem over the past two decades. Non-surgical management of obesity does not often achieve its long term goals. Surgical treatment is roaring in popularity because of dramatic and durable results. However, outcomes from bariatric surgery have become a significant area of scru...

    journal_title:Psychiatry investigation

    pub_type: 杂志文章

    doi:10.4306/pi.2015.12.1.152

    authors: Nepal H,Bhattarai M,Agustin ET

    更新日期:2015-01-01 00:00:00