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Superantigen profiling of Staphylococcus aureus infective endocarditis isolates.

Abstract：

:The frequency of superantigen production among Staphylococcus aureus isolates associated with endocarditis is not well defined. We tested 154 S. aureus isolates from definite infective endocarditis cases for the presence of staphylococcal enterotoxins A-E, H, and TSST-1 by PCR, enzyme-linked immunosorbent assay, and using an HLA-DR3 transgenic mouse splenocyte proliferation assay. Sixty-three isolates (50.8%) tested positive for at least 1 superantigen gene, with 21 (16.9%) testing positive for more than 2. tst (28.6%) was most common, followed by seb (27%), sea (22.2%), sed (20.6%), see (17.5%), and sec (11.1%). Of 41 methicillin-resistant S. aureus, 21 had superantigen genes, with sed being more frequently detected in this group compared to methicillin-susceptible S. aureus (P < 0.05). Superantigen genes were not associated with mortality (P = 0.81). 75% of PCR-positive isolates induced robust splenocyte proliferation. Overall, more than half of S. aureus isolates causing endocarditis carry superantigen genes, of which most are functional.

journal_name

Diagn Microbiol Infect Dis

journal_title

Diagnostic microbiology and infectious disease

authors

Chung JW,Karau MJ,Greenwood-Quaintance KE,Ballard AD,Tilahun A,Khaleghi SR,David CS,Patel R,Rajagopalan G

doi

10.1016/j.diagmicrobio.2014.03.009

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

119-24

issue

2

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(14)00119-9

journal_volume

79

pub_type

杂志文章

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