Cefotaxime in the treatment of staphylococcal infections. Comparison of in vitro and in vivo studies.

Abstract:

:Staphylococcus aureus strains are well-established pathogens that may cause mild to serious life-threatening disease. Coagulase-negative staphylococci, particularly Staphylococcus epidermidis, also have a pathogenic role in humans and cause infections primarily associated with prosthetic devices and indwelling catheters, whereas Staphylococcus saprophyticus usually causes urinary tract infections. Cefotaxime is a "third-generation" cephalosporin that is stable to the staphylococcal beta-lactamases. In vitro studies over the last 15 years have shown that this parenteral cephalosporin has remained highly active (MIC90 ranges of < or = 2-8 micrograms/ml) against oxacillin-susceptible staphylococci. Cefotaxime therapy of staphylococcal infections has resulted in clinical cure/improvement rates ranging from 78%-100% and bacteriologic eradication rates ranging from 85%-100% in a wide variety of infections. Contrary to contemporary dogma, this "third-generation" cephalosporin appears to be efficacious against staphylococcal infections from a review of 15 years of clinical experience.

authors

Aldridge KE

doi

10.1016/0732-8893(95)00051-b

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

195-201

issue

1-2

eissn

0732-8893

issn

1879-0070

pii

0732-8893(95)00051-B

journal_volume

22

pub_type

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