Localization of terminal complement components S-protein and SP-40,40 in renal biopsies.

Abstract:

:The terminal complement complex has been implicated in the development of glomerular injury in both experimental and, indirectly, in human glomerulonephritis. Recent data suggests that the terminal complement complex in human glomerulonephritis may be in the cytolytically inactive SC5b-9 form which also contains S-protein and a recently identified protein, SP-40,40. In this study renal biopsies were examined by immunofluorescence to determine the incidence and inter-relation of deposition of the SC5b-9 components C6, C9, S-protein and SP-40,40. All components of SC5b-9 were found in arteries and arterioles, along the tubular basement membrane and in areas of glomerulosclerosis in all biopsies. This deposition was sometimes associated with C3 but never immunoglobulin deposition and correlated with the degree of renal injury. In addition, in biopsies with glomerular deposition of immunoglobulin and C3, the SC5b-9, components co-localized with the immune deposits. Glomeruli without immune deposits or glomerulosclerosis contained none of the SC5b-9 components. The incidence and pattern of distribution of SP-40,40 was similar to that of S-protein, C6 and C9 in all of cases. These data confirm that the terminal complement complex in the kidney is, at least partly, in the SC5b-9 form both in the specific immune glomerular deposition and in the "non-specific" deposition in areas of renal injury. SP-40,40 is also found in the SC5b-9 complex in all forms of renal disease.

journal_name

Pathology

journal_title

Pathology

authors

Murphy BF,Davies DJ,Morrow W,d'Apice AJ

doi

10.3109/00313028909061073

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

275-8

issue

4

eissn

0031-3025

issn

1465-3931

journal_volume

21

pub_type

杂志文章
  • Expression of CCL21 by EBV-associated gastric carcinoma cells protects CD8+CCR7+ T lymphocytes from apoptosis via the mitochondria-mediated pathway.

    abstract::About 10% of gastric carcinomas are associated with Epstein-Barr virus (EBV), which are defined as EBV-associated gastric carcinomas (EBVaGCs). EBVaGCs are usually accompanied by massive lymphocytes infiltration, among which CD8+ T cells are predominant. To date, the apoptosis of the infiltrating CD8+ T cells in EBVaG...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2018.05.004

    authors: Tang F,Chen JN,Zhang NN,Gong LP,Jiang Y,Feng ZY,Xiao L,Li HG,Du H,Wu B,Shao CK

    更新日期:2018-10-01 00:00:00

  • The pathology of oral cancer.

    abstract::Oral cancer is a serious public health problem, with over 200,000 new cases reported annually worldwide, two-thirds of which occur in developing countries. The overall mortality rate for intra-oral cancer remains high at approximately 50%, even with modern medical services, probably due to the advanced stage of the di...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00310290310001602558

    authors: Walker DM,Boey G,McDonald LA

    更新日期:2003-10-01 00:00:00

  • Immunoradiometric assay of plasma lactoferrin.

    abstract::The concentration of lactoferrin, a non-heme iron binding glycoprotein, was determined in more than 1500 EDTA plasma samples by a 2-site solid phase immunoradiometric assay to assess the significance of lactoferrin in plasma and to investigate applications for this assay. The use of commercially available antibody and...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309061398

    authors: Brown RD,Rickard KA,Kronenberg H

    更新日期:1983-01-01 00:00:00

  • Intraductal carcinoma of the prostate metastatic to the penile urethra: a rare demonstration of two morphologic patterns of tumor growth.

    abstract::Penile metastases from prostate cancer are rare and are usually a manifestation of wide-spread cancer dissemination. Isolated urethral metastases form a small fraction of these cases, have a longer survival rate and may represent spread by implantation following instrumentation. We report a case of prostatic carcinoma...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313029800169306

    authors: Taylor GB,McNeal JE,Cohen RJ

    更新日期:1998-05-01 00:00:00

  • Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management.

    abstract::Histopathologists are encountering intra-lobular epithelial proliferations more frequently in core biopsies taken from lesions identified in mammographic breast screening programmes. In particular, columnar cell lesions are increasingly being seen in core biopsies taken for the histological assessment of mammographica...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313020701230849

    authors: Pinder SE,Provenzano E,Reis-Filho JS

    更新日期:2007-04-01 00:00:00

  • Malignant mesothelioma in situ: diagnostic and clinical considerations.

    abstract::In situ stages of malignancy have been characterised in various neoplasms. Mesothelioma in situ (MIS) has been a controversial diagnosis, lacking clear diagnostic criteria and understanding as to whether it is truly a premalignant lesion in the progression of malignant mesothelioma (MM). Originally understood as a con...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2020.06.010

    authors: Pulford E,Henderson DW,Klebe S

    更新日期:2020-10-01 00:00:00

  • An evaluation of potentially suitable fixatives for immunoperoxidase staining of estrogen receptors in imprints and frozen sections of breast carcinoma.

    abstract::The estrogen receptor (ER) content of breast carcinoma is generally accepted as valuable in predicting clinical outcome and tumour response to hormonal manipulation. We applied a new immunocytochemical assay for estrogen receptors (Abbott ERICA Monoclonal) to 20 breast tumours, and examined the efficacy of 16 fixation...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028809085211

    authors: Raymond WA,Leong AS

    更新日期:1988-10-01 00:00:00

  • Hepatic granuloma in a man from North America caused by a nymph of Linguatula serrata.

    abstract::A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028809066635

    authors: Baird JK,Kassebaum LJ,Ludwig GK

    更新日期:1988-04-01 00:00:00

  • An immunohistochemical and molecular analysis of papillary proliferation of the endometrium.

    abstract::Papillary proliferations of the endometrium (PPEs) are uncommon lesions that are often associated with endometrial polyps. PPEs occasionally precede or co-exist with atypical endometrial hyperplasia or adenocarcinoma, but their pathogenesis and relationship to endometrial neoplasia is uncertain. In the present study 1...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2017.10.013

    authors: Stewart CJR,Bigby S,Giardina T,Grieu-Iacopetta F,Amanuel B

    更新日期:2018-04-01 00:00:00

  • Intracytoplasmic barium salts in pleural fluid.

    abstract::Cytological examination of the pleural effusion fluid obtained from a 66-yr-old Chinese lady showed numerous intra- and extracytoplasmic colourless refractile non-birefringent crystals. X-ray analysis of the crystals identified barium salts. On further inquiry, it was learnt that the fluid obtained had been placed in ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029309090870

    authors: Chan AC,Collins RJ,Cheung TK

    更新日期:1993-10-01 00:00:00

  • Premalignant lesions of the urinary bladder.

    abstract::Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1097/PAT.0b013e32835f6169

    authors: Samaratunga H,Martignoni G,Egevad L,Delahunt B

    更新日期:2013-04-01 00:00:00

  • Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma.

    abstract:AIM:To compare the relative diagnostic efficacy of several different tests used to establish a diagnosis of phaeochromocytoma, in patients with a proven diagnosis of phaeochromocytoma, and in hospital patients with significant disease of other types. METHODS:We prospectively compared biochemical markers of catecholami...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802579284

    authors: Hickman PE,Leong M,Chang J,Wilson SR,McWhinney B

    更新日期:2009-02-01 00:00:00

  • Gastrointestinal stromal tumours (GISTs): a clinicopathological and molecular study of 66 cases.

    abstract:AIMS:Predicting the clinical behaviour of gastrointestinal stromal tumours (GISTs) is difficult and criteria delineating benign from malignant cases are not firmly established. The aims of this study were to define the clinicopathological and molecular features of 66 GISTs, and to determine whether any specific paramet...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020400023628

    authors: Koay MH,Goh YW,Iacopetta B,Grieu F,Segal A,Sterrett GF,Platten M,Spagnolo DV

    更新日期:2005-02-01 00:00:00

  • Multiple hepatic abscesses due to Yersinia enterocolitica.

    abstract::We report a case of multiple hepatic abscesses due to Yersinia enterocolitica in a 58 yr old male. This case is typical of the other 39 cases reported in the literature in that the patient had alcoholism, malnutrition, iron overload and a subsequently diagnosed malignancy. Ultrasound showed multiple hypoechoic areas i...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1080/00313029500169353

    authors: Strungs I,Farrell DJ,Matar LD,Dekker L,Franz RJ

    更新日期:1995-10-01 00:00:00

  • Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour.

    abstract:AIMS:To correlate the immunostaining for INI1 protein and mutations in INI1 gene in possible rhabdoid tumours (RT) and atypical teratoid/rhabdoid tumours (AT/RT) seen at the Royal Children's Hospital in the last 10 years, and to study the clinicopathological features of those patients with negative nuclear staining. M...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802436451

    authors: Wu X,Dagar V,Algar E,Muscat A,Bandopadhayay P,Ashley D,Wo Chow C

    更新日期:2008-12-01 00:00:00

  • Susceptibility of Campylobacter jejuni to twenty-three antimicrobial agents.

    abstract::Twenty-three antimicrobial agents, including 4 new broadspectrum beta-lactam antibiotics were tested against 50 clinical isolates of Campylobacter jejuni. The activity of metabolites of metronidazole and tinidazole was also tested. Minimum inhibitory concentrations (MIC) were determined by agar dilution. beta-lactamas...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309061403

    authors: Shanker S,Sorrell TC

    更新日期:1983-01-01 00:00:00

  • Low-calcium/high-phosphorus rickets in rats. II. Osteoclast changes.

    abstract::Weanling rats were given a low Ca (0.003%)/high P (0.64%) diet with and without vitamin D for periods up to 6 weeks. An ultrastructural examination of selected areas of the proximal tibial metaphysis was carried out to study osteoclasts and their relation to calcified and uncalcified bone tissue. Osteoclasts were seen...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027909059045

    authors: Feik SA,Storey E

    更新日期:1979-10-01 00:00:00

  • TROP-2 immunohistochemistry: a highly accurate method in the differential diagnosis of papillary thyroid carcinoma.

    abstract::We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and medullar...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2016.04.002

    authors: Bychkov A,Sampatanukul P,Shuangshoti S,Keelawat S

    更新日期:2016-08-01 00:00:00

  • Identification of the components of glomerular immune deposits using monoclonal antibodies.

    abstract::Monoclonal antibodies have been raised against components of glomerular immune deposits in experimental glomerulonephritis and idiopathic human glomerulonephritis. An accelerated model of chronic serum sickness in the rat using cationized human serum albumin was employed to obtain renal tissue with capillary loop and ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028809066623

    authors: Murphy BF,d'Apice AJ

    更新日期:1988-04-01 00:00:00

  • Diagnostic problem caused by an atypical creatine kinase isoenzyme in a patient with myocardial infarction.

    abstract::This report describes the diagnostic problem caused by an atypical immunoglobulin-bound creatine kinase isoenzyme in a patient who had a myocardial infarction. In the presence of this atypical isoenzyme, creatine kinase isoenzyme electrophoresis was of no help in determining whether myocardial infarction had occurred....

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313029009061424

    authors: Campbell BG,Jones BW,Burnet J

    更新日期:1990-01-01 00:00:00

  • Promiscuous genes involved in recurrent chromosomal translocations in soft tissue tumours.

    abstract::Soft tissue tumours represent a heterogeneous group of mesenchymal lesions and their classification continues to evolve as a result of incorporating advances in cytogenetic and molecular techniques. In the last decade, traditional diagnostic approaches were supplemented with a significant number of reliable molecular ...

    journal_title:Pathology

    pub_type: 杂志文章,评审

    doi:10.1097/PAT.0000000000000049

    authors: Antonescu CR,Dal Cin P

    更新日期:2014-02-01 00:00:00

  • Development of paediatric biochemistry centile charts as a complement to laboratory reference intervals.

    abstract::Age-specific paediatric reference intervals are used in interpretation of laboratory results. However, interpretation may be problematic when a child just crosses an age bracket and the difference between the original and the subsequent age-specific reference interval is large. Moreover, details about the physiologica...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000118

    authors: Loh TP,Antoniou G,Baghurst P,Metz MP

    更新日期:2014-06-01 00:00:00

  • High reproducibility is attainable in assessing histoprognostic parameters of pT1 colorectal cancer using routine histopathology slides and immunohistochemistry analyses.

    abstract::Assessment of the risk of lymph node invasion and tumour recurrence is critical to determine whether additional surgery is required in patients with endoscopically-removed pT1 colorectal cancer (CRC). A reproducible assessment of this risk of recurrence based on histopathological parameters is crucial for relevant the...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1016/j.pathol.2018.10.007

    authors: Barel F,Auffret A,Cariou M,Kermarrec T,Samaison L,Bourhis A,Badic B,Jézéquel J,Cholet F,Bail JP,Marcorelles P,Nousbaum JB,Robaszkiewicz M,Doucet L,Uguen A

    更新日期:2019-01-01 00:00:00

  • Gene expression in mixed type liposarcoma.

    abstract:AIMS:Mixed type liposarcomas are rare. Here, we analysed the characteristics of an unusual case of mixed type liposarcoma, which consisted of a well-differentiated liposarcoma (WDL) and a pleomorphic liposarcoma (PL), with a special emphasis on molecular alterations. METHODS:Microscopic and immunohistochemical approac...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020600557078

    authors: Kim JI,Choi KU,Lee IS,Moon TY,Lee CH,Kim HW,Kim JY,Park DY,Sol MY

    更新日期:2006-04-01 00:00:00

  • Rare (new) entities of the breast and medullary carcinoma.

    abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1080/00313020802563528

    authors: Foschini MP,Eusebi V

    更新日期:2009-01-01 00:00:00

  • Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene.

    abstract:AIMS:Activation of β-catenin has been identified as a possible mechanism for the development of nephroblastomas. In our study we investigated whether this activation occurs already in precursor lesions of nephroblastomas, called nephrogenic rests (NRs). Inactivation of the adenomatous polyposis coli (APC) protein is an...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0b013e32834bf65c

    authors: Grill C,Sunitsch S,Hatz M,Hauser-Kronberger C,Leuschner I,Hoefler G,Guertl B

    更新日期:2011-12-01 00:00:00

  • A rapid method for assessing megathrombocytes: its application to thrombocytotic and acquired thrombocytopenic states.

    abstract::A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027609094424

    authors: Hunt FA

    更新日期:1976-01-01 00:00:00

  • BRAFV600E mutation analysis by immunohistochemistry in patients with thoracic metastases from colorectal cancer.

    abstract::The BRAF(V600E) mutation confers worse prognosis to metastatic colorectal cancer (mCRC) patients. In addition, this mutation has a negative predictive value for response to treatment with monoclonal antibodies against EGFR in patients with KRAS wild-type (wt) mCRC. The utility of immunohistochemistry (IHC) as an alter...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.1097/PAT.0000000000000113

    authors: Ilie MI,Long-Mira E,Hofman V,Mouroux J,Vignaud JM,Gauchotte G,Begueret H,Merlio JP,Emile JF,Hébuterne X,Hofman P

    更新日期:2014-06-01 00:00:00

  • Perhexiline maleate induced cirrhosis.

    abstract::Perhexiline maleate is a potent anti-anginal drug which may cause alcoholic-type hepatitis and cirrhosis. We report a case of a patient who developed cirrhosis on a relatively low dose within 16 mth. ...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313028309084714

    authors: Pieterse AS,Rowland R,Dunn D

    更新日期:1983-04-01 00:00:00

  • The iso-enzyme of alkaline phosphatase in neutrophils during pregnancy.

    abstract::The alkaline phosphatase from neutrophils of pregnant women and normal males has been extracted, subjected to various inhibitory procedures and to electrophoresis. It is demonstrated that the iso-enzyme obtained from each group is indistinguishable from the skeletal iso-enzyme, in contrast to the serum iso-enzyme of p...

    journal_title:Pathology

    pub_type: 杂志文章

    doi:10.3109/00313027709085233

    authors: Findlay AB,Johnston NG

    更新日期:1977-01-01 00:00:00