Abstract:
:Oral cancer is a serious public health problem, with over 200,000 new cases reported annually worldwide, two-thirds of which occur in developing countries. The overall mortality rate for intra-oral cancer remains high at approximately 50%, even with modern medical services, probably due to the advanced stage of the disease at presentation. This review outlines recent advances in our understanding of the roles and interactions of major risk factors for oral cancer worldwide, notably tobacco, alcohol and betel quid and the genetic polymorphisms determining their metabolism that may predispose patients to oral carcinoma. Oral epithelial lesions with malignant potential are described. We discuss the histopathology of oral cancer, its grading and the staging of the disease at clinical, microscopic, immunohistological and molecular levels. A recommended minimum dataset for pathology reports is described. The available strategies and current prospects for controlling oral cancer in the community are summarised.
journal_name
Pathologyjournal_title
Pathologyauthors
Walker DM,Boey G,McDonald LAdoi
10.1080/00310290310001602558subject
Has Abstractpub_date
2003-10-01 00:00:00pages
376-83issue
5eissn
0031-3025issn
1465-3931pii
9NLGYYNG3DJ0DN0Rjournal_volume
35pub_type
杂志文章,评审相关文献
PATHOLOGY文献大全abstract::The clinical and laboratory features of a patient with a recently recognized new variant of von Willebrand's disease are presented. The importance of this variant is that it is associated with a clinically significant bleeding diathesis but with a normal skin bleeding time, PTTK, factor VIIIc and platelet aggregation ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085199
更新日期:1988-01-01 00:00:00
abstract::Ulex europaeus agglutinin-1 (UEA-1) binds specifically to alpha-L-fucose, the terminal sugar of blood group substances H2 and Ley the expression of which is confined mainly to the proximal colon. The aim of the study was to determine whether there is neo-expression of alpha-L-fucose in the normal appearing mucosa of t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029309084782
更新日期:1993-04-01 00:00:00
abstract:AIMS:Immunohistochemical detection of the 185-kDa transmembrane glycoprotein product of the proto-oncogene c-erbB-2 (also known as HER-2/neu), located on chromosome 17q21, is a well established method of evaluation in invasive breast cancer. This investigation is currently performed on standard sections cut from the tu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600820872
更新日期:2006-08-01 00:00:00
abstract::Rare tumours are a heterogeneous group of conditions that encompass benign to malignant lesions both of stromal and epithelial origin. Here some of these tumours are described, in which the authors have most familiarity. An outline of medullary carcinoma is also presented. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802563528
更新日期:2009-01-01 00:00:00
abstract::The use of purified intrinsic factor in vitamin B12 radioassays has greatly reduced the misdiagnosis of pernicious anaemia in recent years, but anomalies still occur. Observations made on current vitamin B12 radioassays suggest that many methods fail to convert all serum cobalamins to cyanocobalamin and thus are not t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209069040
更新日期:1982-01-01 00:00:00
abstract::Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor IX is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role i...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029700169954
更新日期:1997-05-01 00:00:00
abstract::The Hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core c...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.01.001
更新日期:2019-04-01 00:00:00
abstract::A new three-tiered Pattern Classification system for usual-type endocervical adenocarcinomas (U-EACs) recommends using tumour invasive patterns rather than depth of invasion (DOI) and horizontal spread to categorise tumours. Tumours categorised by Pattern Classification are associated with lymph node (LN) metastasis a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.04.008
更新日期:2019-10-01 00:00:00
abstract::Chromosome identification techniques have shown the non-random nature of cytogenetic changes in leukemia. In addition, they have identified structural chromosome abnormalities occurring in specific types of acute leukemia as classified by the FAB criteria. Such cytogenetic sub groups are associated with differing prog...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028209061379
更新日期:1982-07-01 00:00:00
abstract::The aims of this study were to investigate the immunohistochemical expression and potential prognostic significance of putative cancer stems cell markers ALDH1, EZH2 and SOX2 in prostate cancer.A total of 142 consecutive radical prostatectomies submitted to one laboratory with a diagnosis of prostatic adenocarcinoma b...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000325
更新日期:2015-12-01 00:00:00
abstract::An indirect haemaglutination method was developed for the immunochemical detection of myoglobin in human urine. Myoglobin was found in the urine of 84% of 44 patients with acute myocardial infarction. In contrast, it was detected in the urine of 2.7% of 147 control subjects and in none of a control group of 15 patient...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027609101494
更新日期:1976-10-01 00:00:00
abstract::A "collision" tumor between a serous papillary adenocarcinoma and a steroid cell tumor of the ovary is described. No similar combination has been reported in the literature. The steroid cell component secreted testosterone, resulted in considerable virilization of the patient, and appears to have preceded the carcinom...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029209063624
更新日期:1992-04-01 00:00:00
abstract::A diptheria immunoglobulin has been prepared from selected blood donations to the Australian Red Cross Transfusion Services. A dose of 250 I.U. has been demonstrated to raise the titre of diptheria antitoxin in non-immune subjects to protective levels within 24 h, and these levels remain protective for at least 5 wk. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909059015
更新日期:1979-07-01 00:00:00
abstract:AIMS:Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Bax-interacting factor-1 (Bif-1) interacts with both Bax and Bak that are crucial for the intrinsic apoptosis signalling. Functionally, loss of Bif-1 expression has been proven to enhance tumorigenesis. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020802320440
更新日期:2008-10-01 00:00:00
abstract::Assessment of the risk of lymph node invasion and tumour recurrence is critical to determine whether additional surgery is required in patients with endoscopically-removed pT1 colorectal cancer (CRC). A reproducible assessment of this risk of recurrence based on histopathological parameters is crucial for relevant the...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2018.10.007
更新日期:2019-01-01 00:00:00
abstract::Results are presented of a study comparing cerbB2 (neu or Her2) expression as assessed immunohistochemically in breast neoplasia using a panel of 6 commercially available antibodies. The antibodies were examined utilizing conventional formalin fixed paraffin embedded tissue, and compared with molecular analysis of gen...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169611
更新日期:1994-07-01 00:00:00
abstract::Twenty-three antimicrobial agents, including 4 new broadspectrum beta-lactam antibiotics were tested against 50 clinical isolates of Campylobacter jejuni. The activity of metabolites of metronidazole and tinidazole was also tested. Minimum inhibitory concentrations (MIC) were determined by agar dilution. beta-lactamas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309061403
更新日期:1983-01-01 00:00:00
abstract:AIMS:Only a small number of mesenchymal tumours have been previously evaluated for hTERT expression. We hypothesised that hTERT expression would be frequently present in sarcomas, but not in benign tumours. METHODS:Sections from 143 bone/soft tissue tumours were immunostained for hTERT (44F12, 1:20; Novocastra) using ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020903121614
更新日期:2009-01-01 00:00:00
abstract::Perhexiline maleate is a potent anti-anginal drug which may cause alcoholic-type hepatitis and cirrhosis. We report a case of a patient who developed cirrhosis on a relatively low dose within 16 mth. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309084714
更新日期:1983-04-01 00:00:00
abstract::The concentration of lactoferrin, a non-heme iron binding glycoprotein, was determined in more than 1500 EDTA plasma samples by a 2-site solid phase immunoradiometric assay to assess the significance of lactoferrin in plasma and to investigate applications for this assay. The use of commercially available antibody and...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309061398
更新日期:1983-01-01 00:00:00
abstract::Plexiform leiomyomas of the uterus are incidental findings in hysterectomy specimens. Histogenetically, these rare tumors are classified as a variant of epithelioid leiomyomas. Most of the plexiform leiomyomas reported range in size from microscopically small lesions to less than 1 cm in largest diameter, and they mac...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130299105197
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously. AIMS:To document the clinical and histopathological findings in a series of patients with DPA. RESULTS:Of the 8 patients identi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32835af778
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Detection of the V600E hotspot mutation in BRAF oncogene is extremely useful for the screening of hereditary non-polyposis colorectal cancer (Lynch's syndrome) and for the prediction of sensitivity to MEK inhibitors. Here we describe a method for detecting this mutation based upon pyrosequencing technology...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020801911512
更新日期:2008-04-01 00:00:00
abstract:AIM:The purpose of this study was to elucidate the clonality of fibrous dysplasia based on X-chromosome inactivation mosaicism and polymorphism in female somatic cells at the phosphoglycerate kinase (PGK) and androgen receptor (AR) loci using microdissection technology. MATERIALS AND METHODS:Nine patients with fibrous...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020801911496
更新日期:2008-06-01 00:00:00
abstract::The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2015.12.006
更新日期:2016-02-01 00:00:00
abstract::Trichostrongylus infection, an uncommonly reported zoonosis in Australia, is common in parts of the world where there is close human contact with herbivorous animals. We report 5 cases diagnosed in our laboratory since 1992. Over this period the laboratory has conducted over 46,000 parasitological examinations on fece...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029500169842
更新日期:1995-04-01 00:00:00
abstract::The intimal thickness of the coronary arteries of humans less than 20 years of age was compared with that 9 other species. It was found that humans were unique amongst the species studied in showing substantial intimal thickening at an early age. The intimal thickening was associated with defects of the internal elast...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028909059547
更新日期:1989-04-01 00:00:00
abstract::Ethanol in blood was assayed by 2 currently available procedures: a commercial kit enzymatic assay and a gas chromatographic procedure. Both methods were performed with commercially available materials and equipment. Results by the 2 procedures agreed well. For the 192 specimens studied, the correlation coefficient wa...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028409059096
更新日期:1984-04-01 00:00:00
abstract::Mycoplasma-like organisms (MLO) are non-cultivated intracellular cell wall deficient pathogenic bacteria with a distinctive ultrastructural appearance. Diagnosis of MLO disease rests on finding the organisms in parasitized cells using a transmission electron microscope. MLO are a well studied cause of transmissible ch...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029400169192
更新日期:1994-10-01 00:00:00
abstract::A retrospective study of gallbladders submitted as surgical specimens over a period of fifteen years (1972-1986) was performed in the Department of Pathology, Queen Mary Hospital, Hong Kong. Seven thousand nine hundred and ten gallbladders were examined. A total of 253 more unusual and significant pathological lesions...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028809085191
更新日期:1988-01-01 00:00:00