Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2.

abstract：:The cancer stem cell hypothesis suggests that malignant tumours may arise from a limited number of specialised cells possessing the key 'stem' properties of self-renewal and the ability to produce differentiated progeny. Such cells purportedly constitute a small fraction of most tumours but have greater potential to p...

journal_title：Pathology

authors： Hemmings C

更新日期：2010-02-01 00:00:00

abstract：:A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...

journal_title：Pathology

authors： Baird JK,Kassebaum LJ,Ludwig GK

更新日期：1988-04-01 00:00:00

abstract：:The current public health emergency surrounding the COVID-19 pandemic, that is the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in thousands of cases in Australia since 25 January 2020 when the first case was diagnosed. This emerging virus presents particular hazards to ...

journal_title：Pathology

authors： Kaufer AM,Theis T,Lau KA,Gray JL,Rawlinson WD

更新日期：2020-12-01 00:00:00

abstract：:Sclerosing adenosis (SA) of the breast if a disease associated with an increase relative risk of malignancy. The exact incidence and factors influencing malignant transformation in association with SA are not well established. Two counts of the AgNOR silver staining technique have been correlated with ploidy and proli...

journal_title：Pathology

authors： Mourad WA

更新日期：1997-08-01 00:00:00

abstract：:Inflammatory pseudotumor (IP) is an uncommon tumor-like lesion of unknown etiology. Two cases of IP of the epididymis were identified in our hospital file. Having read a recent report on finding Epstein-Barr virus (EBV) in some cases of IP in lymph node, spleen and liver, the two cases of epididymal IP were tested for...

journal_title：Pathology

authors： Chan KW,Chan KL,Lam KY

更新日期：1997-02-01 00:00:00

abstract：:Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labe...

journal_title：Pathology

authors： Gupta S,Johnstone R,Darby H,Selden C,Price Y,Hodgson HJ

更新日期：1987-01-01 00:00:00

abstract：:Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

journal_title：Pathology

authors： Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

更新日期：1987-10-01 00:00:00

abstract：:Twelve thromboplastins were tested against a secondary reference thromboplastin (human brain CRM BCR No. 147) or a tertiary house standard (human brain thromboplastin) with plasmas from normal healthy individuals and patients on oral anticoagulant therapy. The relationship between the prothrombin ratios of the thrombo...

journal_title：Pathology

authors： Moriarty HT,Lam-Po-Tang PR,Anastas N

更新日期：1990-04-01 00:00:00

abstract：:Multiplex immunofluorescence (mIF) allows simultaneous antibody-based detection and quantification of the expression of up to six markers, plus a nuclear counterstain, on a single tissue section. Recent studies have shown the potential for mIF to advance our understanding of complex disease processes, including cancer...

journal_title：Pathology

authors： Lim JCT,Yeong JPS,Lim CJ,Ong CCH,Wong SC,Chew VSP,Ahmed SS,Tan PH,Iqbal J

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to establish the diagnostic utility of p53 immunohistochemistry in Barrett's esophagus. Three pathologists reviewed endoscopic biopsy specimens and one surgical specimen derived from 102 subjects in a prospective follow-up series. Dysplasia was graded as negative, indefinite, low grade and hi...

journal_title：Pathology

authors： Khan S,Do KA,Kuhnert P,Pillay SP,Papadimos D,Conrad R,Jass JR

更新日期：1998-05-01 00:00:00

abstract：:The mitogenic and chemotactic potency of platelet-derived growth factor (PDGF) has linked this polypeptide to the pathogenesis of several disease states including atherosclerosis and neoplasia. We have reviewed the recent literature on aspects relating to the structure, distribution and biology of PDGF and its high-af...

journal_title：Pathology

authors： Khachigian LM,Chesterman CN

更新日期：1992-10-01 00:00:00

abstract：:Eight histologically-confirmed cases of clear cell sarcoma of the kidney (CCSK) were studied for possible mutations in the p53 tumor suppressor gene by the immunohistochemical demonstration of mutant p53 proteins using a monoclonal (DO7: Dako) and a polyclonal (AB565: Chemicon) antibody to p53 protein. All cases exhib...

journal_title：Pathology

authors： Cheah PL,Looi LM

更新日期：1996-08-01 00:00:00

abstract：:Micropapillary carcinoma of the colon and rectum is associated with an adverse prognosis. This tumour type displays reverse polarity of the tumour cells and is stated to be characterised by an inside-out epithelial membrane antigen (EMA)/MUC1 staining. Nine cases of primary colorectal carcinoma and one omental metasta...

journal_title：Pathology

authors： Cserni G

更新日期：2014-10-01 00:00:00

abstract：:The first 2 exchange transfusions in Australia for Rhesus-induced erythroblastosis (hemolytic disease of the newborn) were conducted in the 9 mth period from December 1945 to August 1946. These pioneering endeavours in medical research were undertaken by 3 transfusionists who were, or had been, directors of the Red Cr...

journal_title：Pathology

authors： Pearn JH

更新日期：1994-04-01 00:00:00

abstract：:A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...

journal_title：Pathology

authors： Kepes JJ,Berry A 3rd,Zacharias DL

更新日期：1988-07-01 00:00:00

abstract：:The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...

journal_title：Pathology

authors： Lee N,Zakka LR,Mihm MC Jr,Schatton T

更新日期：2016-02-01 00:00:00

abstract：:Four hundred and ten thyroid nodules, 127 breast lumps and 43 lymph nodes were sampled and analyzed to compare the classical aspiration (ASP) technique with the non aspiration needle jab (NASP) technique. The adequacy of cellularity, significant blood staining and the discomfort felt by the patient were assessed and s...

journal_title：Pathology

authors： Kumarasinghe MP,Sheriffdeen AH

更新日期：1995-10-01 00:00:00

abstract：:Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 ...

journal_title：Pathology

authors： Shanmugaratnam K,Kunaratnam N,Chia KB,Chiang GS,Sinniah R

更新日期：1983-10-01 00:00:00

abstract：:The case is reported of a woman aged 60 yrs who presented with systemic symptoms and who was found to have proteinuria of 3.5 g per day. A renal biopsy revealed numerous neoplastic cells filling many of the glomerular capillary lumina. Immunoperoxidase stains revealed that the phenotype of the malignant cells was LCA+...

journal_title：Pathology

authors： Axelsen RA,Laird PP,Horn M

更新日期：1991-07-01 00:00:00

abstract：:Rheumatoid Arthritis (RA) synovial membranes were examined by single and dual immunohistological techniques with a number of monoclonal antibodies against lymphocyte and macrophage related antigens. CD4 positive T lymphocytes frequently expressed MHC Class II antigens and were found in sublining collections in close a...

journal_title：Pathology

authors： Smith MD,O'Donnell J,Highton J,Palmer DG,Rozenbilds M,Roberts-Thomson PJ

更新日期：1992-01-01 00:00:00

abstract：:Recent updated models of the coagulation mechanism suggest that factor VII/thromboplastin complex is the main initiator or trigger of coagulation. Factor VII activation of factor IX is likely to be an important activation pathway. Inhibition of factor VII by tissue factor pathway inhibitor may have a regulatory role i...

journal_title：Pathology

authors： Wei DC,Wong RW,Robertson EP

更新日期：1997-05-01 00:00:00

abstract：:The frequency of simultaneous infection with Neisseria gonorrhoeae and Chlamydia trachomatis in men and women in Eastern Sydney was examined prospectively over a 21 month period in patients from whom appropriate specimens were obtained. In men gonococcal disease (113 cases) and chlamydial infections (124 cases) occurr...

journal_title：Pathology

authors： Tapsall JW,Kinchington M

更新日期：1996-01-01 00:00:00

abstract：:We describe a 44-year-old female with a known history of a solitary osteochondroma of the scapula followed on X-ray for five years. She then presented with a rapidly growing lump. Imaging studies confirmed the presence of an aggressive looking lesion. Excision was performed and pathology showed a dedifferentiated chon...

journal_title：Pathology

authors： Radhi JM,Loewy J

更新日期：1999-11-01 00:00:00

abstract：AIMS:Twenty-six cases of granulomatous mastitis were examined to determine the common histological and clinical features and the possible association with micro-organisms. METHODS:A retrospective review of the clinical and histological features of these cases was undertaken, including granuloma, inflammatory cell infi...

journal_title：Pathology

authors： Tse GM,Poon CS,Ramachandram K,Ma TK,Pang LM,Law BK,Chu WC,Tang AP,Cheung HS

更新日期：2004-06-01 00:00:00

abstract：:A rapid technique suitable for routine laboratory use for determining the percentage of large platelets in the peripheral blood is described. In 50 haematologically normal subjects, megathrombocytes (platelets with a volume of 16-33 fl) constituted 3.0-16.6% (mean +/- 2 SD) of the platelet count. Of the 10 patients ex...

journal_title：Pathology

authors： Hunt FA

更新日期：1976-01-01 00:00:00

abstract：AIMS:The roles of tumour suppressor genes: adenomatous polyposis coli (APC) and E-cadherin (CDH1) were investigated in clear cell renal cell carcinoma. METHODS:Forty-five human clear cell renal cell carcinomas were tested for APC gene instability by polymerase chain reaction/loss of heterozygosity using the restrictio...

journal_title：Pathology

authors： Pećina-SLaus N,Gall-TroSelj K,SLaus M,Radić K,NikuSeva-Martić T,Pavelić K

更新日期：2004-04-01 00:00:00

abstract：AIMS:We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome. METHODS:Clinicopathological data were obtained from 140 cases of triple negative breast cancer. A t...

journal_title：Pathology

authors： De Brot M,Rocha RM,Soares FA,Gobbi H

更新日期：2012-06-01 00:00:00

abstract：:Recent controversies both in Australia and overseas have focused public attention on autopsy practice. It has become apparent that there is an increasing expectation amongst the public for more detailed information concerning autopsy procedures and, in particular, tissue retention. This article attempts to review the ...

journal_title：Pathology

authors： Lynch MJ

更新日期：2002-02-01 00:00:00

abstract：:IgG4 related disease (IgG4RD) is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. Although rare, mammary involvement has been reported as IgG4...

journal_title：Pathology

authors： Chougule A,Bal A,Das A,Singh G

更新日期：2015-01-01 00:00:00

abstract：AIM:To determine whether the common respiratory pathogen, Chlamydia pneumoniae, was associated with atherosclerotic plaques in Australian subjects. METHODS:A total of 29 coronary atherosclerotic lesions and 18 normal coronary arterial samples were tested for the presence of C. pneumoniae by PCR and immunofluorescence ...

journal_title：Pathology

authors： Cochrane M,Kalle WH,Roffey P,Moriarty HT

更新日期：2002-06-01 00:00:00