Abstract:
:Many nonrandomized interventions rely upon a pre-post design to evaluate effectiveness. Such designs cannot account for events external to the intervention that may produce the outcome. We describe a method to construct a surveillance registry-based comparison group, which allows for estimating the effectiveness of the intervention while controlling for secular trends in the outcome of interest. Using data from the population-based, human immunodeficiency virus Surveillance Registry in New York City, we created a contemporaneous comparison group for persons enrolled in the New York City human immunodeficiency virus Care Coordination Program (CCP) from December 2009 to March 2013. Inclusion in the Registry-based (non-CCP) comparison group required meeting CCP eligibility criteria. To control for secular trends in the outcome, we randomly assigned persons in the non-CCP, Registry-based comparison group a pseudoenrollment date such that the distribution of pseudoenrollment dates matched the distribution of enrollment dates among CCP enrollees. We then matched CCP to non-CCP persons on propensity for enrollment in the CCP, enrollment dates, and baseline viral load. Registry-based comparison group estimates were attenuated relative to pre-post estimates of program effectiveness. These methods have broad applicability for observational intervention effectiveness studies and programmatic evaluations for conditions with surveillance registries.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Robertson MM,Waldron L,Robbins RS,Chamberlin S,Penrose K,Levin B,Kulkarni S,Braunstein SL,Irvine MK,Nash Ddoi
10.1093/aje/kwy103subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1980-1989issue
9eissn
0002-9262issn
1476-6256pii
5000160journal_volume
187pub_type
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