Abstract:
:The relation between measures of general and central adiposity and individual cardiovascular endpoints remains understudied in older adults. This study investigated the association of measures of body size and composition with incident ischemic stroke or coronary heart disease (1989-2007) in 3,754 community-dwelling US adults aged 65-100 years. Standardized anthropometry and bioelectric impedance measurements were obtained at baseline. Body mass index at age 50 years (BMI50) was calculated on the basis of recalled weight. Although only waist/hip ratio was significantly associated with ischemic stroke in quintile analysis in women, dichotomized body mass index (BMI) (≥ 30 kg/m²) was the only significant predictor in men. For coronary heart disease, there were significant positive adjusted associations for all adiposity measures, without interaction by sex. This was true for both quintiles and conventional cutpoints for obesity, although BMI-defined overweight (25-29.9 kg/m² was significant at midlife but not at baseline. Strengths of association for extreme quintiles (quintile 5 vs. quintile 1) were broadly comparable, but the highest effect estimates were for waist/hip ratio (hazard ratio = 1.56, 95% confidence interval: 1.25, 1.94) and BMI50 (hazard ratio = 1.71, 95% confidence interval: 1.37, 2.14), both of which remained significant after adjustment for mediators, BMI, or each other. Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Kizer JR,Biggs ML,Ix JH,Mukamal KJ,Zieman SJ,de Boer IH,Mozaffarian D,Barzilay JI,Strotmeyer ES,Luchsinger JA,Elkind MS,Longstreth WT Jr,Kuller LH,Siscovick DSdoi
10.1093/aje/kwq311subject
Has Abstractpub_date
2011-01-01 00:00:00pages
10-25issue
1eissn
0002-9262issn
1476-6256pii
kwq311journal_volume
173pub_type
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