Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators.

Abstract:

:Mendelian randomization (MR) is a method for estimating the causal relationship between an exposure and an outcome using a genetic factor as an instrumental variable (IV) for the exposure. In the traditional MR setting, data on the IV, exposure, and outcome are available for all participants. However, obtaining complete exposure data may be difficult in some settings, due to high measurement costs or lack of appropriate biospecimens. We used simulated data sets to assess statistical power and bias for MR when exposure data are available for a subset (or an independent set) of participants. We show that obtaining exposure data for a subset of participants is a cost-efficient strategy, often having negligible effects on power in comparison with a traditional complete-data analysis. The size of the subset needed to achieve maximum power depends on IV strength, and maximum power is approximately equal to the power of traditional IV estimators. Weak IVs are shown to lead to bias towards the null when the subsample is small and towards the confounded association when the subset is relatively large. Various approaches for confidence interval calculation are considered. These results have important implications for reducing the costs and increasing the feasibility of MR studies.

journal_name

Am J Epidemiol

authors

Pierce BL,Burgess S

doi

10.1093/aje/kwt084

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1177-84

issue

7

eissn

0002-9262

issn

1476-6256

pii

kwt084

journal_volume

178

pub_type

杂志文章
  • Indicators of fat distribution, serum lipids, and blood pressure in European women born in 1948--the European Fat Distribution Study.

    abstract::In the spring of 1986, the authors studied the relation between body mass index and anthropometric indicators of fat distribution to cardiovascular risk factors (serum lipids and blood pressure) in approximately 450 women aged 38 years randomly selected from population registers in five European centers. Waist circumf...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115322

    authors: Seidell JC,Cigolini M,Charzewska J,Ellsinger BM,Di Biase G,Björntorp P,Hautvast JG,Contaldo F,Szostak V,Scuro LA

    更新日期:1989-07-01 00:00:00

  • Prostatic cancer: mortality and incidence rates by race and social class.

    abstract::Among the most striking epidemiologic characteristics of prostatic cancer in the United States is the sizeable excess in rates for the disease among blacks as compared with whites. This study attempted to determine whether the higher black rates might be explained by controlling for social class, using mortality data ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112546

    authors: Ernster VL,Selvin S,Sacks ST,Austin DF,Brown SM,Winkelstein W Jr

    更新日期:1978-04-01 00:00:00

  • The role of measurement error in estimating levels of physical activity.

    abstract::Epidemiologic studies have demonstrated that physical inactivity is an important determinant of numerous chronic diseases. However, self-reported estimates of physical activity contain measurement errors responsible for attenuating relative risk estimates. A validation study conducted in 2002-2003 at the Alberta Cance...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm148

    authors: Ferrari P,Friedenreich C,Matthews CE

    更新日期:2007-10-01 00:00:00

  • Exercise During the First Trimester and Infant Size at Birth: Targeted Maximum Likelihood Estimation of the Causal Risk Difference.

    abstract::This cohort study sought to estimate the differences in risk of delivering infants who were small or large for gestational age (SGA or LGA, respectively) according to exercise during the first trimester of pregnancy (vs. no exercise) among 2,286 women receiving care at Kaiser Permanente Northern California in 2013-201...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz213

    authors: Ehrlich SF,Neugebauer RS,Feng J,Hedderson MM,Ferrara A

    更新日期:2020-02-28 00:00:00

  • Using Bounds to Compare the Strength of Exchangeability Assumptions for Internal and External Validity.

    abstract::In the absence of strong assumptions (e.g., exchangeability), only bounds for causal effects can be identified. Here we describe bounds for the risk difference for an effect of a binary exposure on a binary outcome in 4 common study settings: observational studies and randomized studies, each with and without simple r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz060

    authors: Breskin A,Westreich D,Cole SR,Edwards JK

    更新日期:2019-07-01 00:00:00

  • PTC1 and PTC2: New Indices of Blood Pressure Waveforms and Cardiovascular Disease.

    abstract::Systolic and diastolic blood pressures provide information about cardiovascular disease (CVD) but are only extremes of the pressure waveform during the cardiac cycle. We developed summaries of the pressure decay, called PTC1 and PTC2, that are related to arterial compliance and to an existing proprietary summary that ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz280

    authors: Brumback LC,Jacobs DR,Duprez DA

    更新日期:2020-07-01 00:00:00

  • Geographic representation of the jackson heart study cohort to the African-American population in Jackson, Mississippi.

    abstract::Recent advances in geographic information systems software and multilevel methodology provide opportunities for more extensive characterization of "at-risk" populations in epidemiologic studies. The authors used age-restricted, geocoded data from the all-African-American Jackson Heart Study (JHS), 2000-2004, to demons...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq317

    authors: Hickson DA,Waller LA,Gebreab SY,Wyatt SB,Kelly J,Antoine-Lavigne D,Sarpong DF

    更新日期:2011-01-01 00:00:00

  • Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case-control study.

    abstract::Experimental and prevalent case-control studies suggest an association between biomarkers of inflammation, endothelial function, and adiposity and cancer risk, but results from prospective studies have been limited. The authors' objective was to prospectively examine the relations between these biomarkers and cancer r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/aje/kws359

    authors: Touvier M,Fezeu L,Ahluwalia N,Julia C,Charnaux N,Sutton A,Méjean C,Latino-Martel P,Hercberg S,Galan P,Czernichow S

    更新日期:2013-01-01 00:00:00

  • Transmission of hepatitis B virus among siblings.

    abstract::The authors investigated families with at least one hepatitis B surface antigen (HBsAg) carried in Okinawa, Japan, to determine possible routes of hepatitis B virus transmission within family units. A total of 175 members of 37 families on the western part of Iriomote Island, Okinawa, were followed up for 2-13 years; ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113923

    authors: Kashiwagi S,Hayashi J,Ikematsu H,Nomura H,Kajiyama W,Shingu T,Hayashida K,Kaji M

    更新日期:1984-10-01 00:00:00

  • International analysis of insulin-dependent diabetes mellitus mortality: a preventable mortality perspective. The Diabetes Epidemiology Research International (DERI) Study.

    abstract::Differential survival associated with insulin-dependent diabetes mellitus (IDDM) was evaluated in a cross-country study using four population-based IDDM cohorts from Japan (n = 1,374), Israel (n = 610), Allegheny County, Pennsylvania (n = 995), and Finland (n = 5,144). For the purpose of this cross-country comparison,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1995-09-15 00:00:00

  • Invited Commentary: The Enduring Role of "Place" in Health-A Historic Perspective.

    abstract::In public health, it has long been observed that "place"-specifically, where one lives-affects individual health, with the main research question distinguishing between the effects of "context" (defined as area characteristics) and "composition" (the characteristics of inhabitants) on health outcomes. There have been ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx085

    authors: Cozier YC

    更新日期:2017-06-01 00:00:00

  • Duration of tick bites in a Lyme disease-endemic area.

    abstract::Regression equations, based on scutal index (body length/scutal width), were developed to determine the duration of attachment for nymphal and adult female lxodes scapularis ticks. Feeding times were calculated for 444 nymphal and 300 female ticks submitted by bite victims between 1985 and 1989 in Westchester County, ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008728

    authors: Falco RC,Fish D,Piesman J

    更新日期:1996-01-15 00:00:00

  • The Cornell Medical Index as a predictor of health in a prospective cardiovascular study in Taiwan.

    abstract::As part of a prospective study of cardiovascular disease (CVD) in middle-aged Chinese men in Taiwan, 1820 Chinese males, aged 40--59 years, from the middle and upper socioeconomic classes, were characterized at study entry by a history and physical examination with particular reference to cardiovascular status and by ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112861

    authors: Weaver CA,Ko YH,Alexander ER,Pao YL,Ting N

    更新日期:1980-01-01 00:00:00

  • Semen Quality as a Predictor of Subsequent Morbidity: A Danish Cohort Study of 4,712 Men With Long-Term Follow-up.

    abstract::Semen quality has been suggested to be a biological marker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of these men were followed in the Danish National Patie...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx067

    authors: Latif T,Kold Jensen T,Mehlsen J,Holmboe SA,Brinth L,Pors K,Skouby SO,Jørgensen N,Lindahl-Jacobsen R

    更新日期:2017-10-15 00:00:00

  • Quality of reporting of observational longitudinal research.

    abstract::Observational longitudinal research is particularly useful for assessing etiology and prognosis and for providing evidence for clinical decision making. However, there are no structured reporting requirements for studies of this design to assist authors, editors, and readers. The authors developed and tested a checkli...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi042

    authors: Tooth L,Ware R,Bain C,Purdie DM,Dobson A

    更新日期:2005-02-01 00:00:00

  • DNA repair and susceptibility to basal cell carcinoma: a case-control study.

    abstract::This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed bet...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117297

    authors: Wei Q,Matanoski GM,Farmer ER,Hedayati MA,Grossman L

    更新日期:1994-10-01 00:00:00

  • What do case-control studies estimate? Survey of methods and assumptions in published case-control research.

    abstract::To evaluate strategies used to select cases and controls and how reported odds ratios are interpreted, the authors examined 150 case-control studies published in leading general medicine, epidemiology, and clinical specialist journals from 2001 to 2007. Most of the studies (125/150; 83%) were based on incident cases; ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn217

    authors: Knol MJ,Vandenbroucke JP,Scott P,Egger M

    更新日期:2008-11-01 00:00:00

  • Air pollution and hospital admissions for the elderly in Birmingham, Alabama.

    abstract::Several studies have reported associations between airborne particles and/or ozone and hospital admissions for respiratory disease. This study examined whether such an association could be seen in Birmingham, Alabama, one of the few cities in the United States with daily monitoring of inhalable particles. Daily counts...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117048

    authors: Schwartz J

    更新日期:1994-03-15 00:00:00

  • Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study.

    abstract::Studies have provided evidence of an inverse association between atopic allergic conditions (AACs) and invasive colorectal cancer (CRC) incidence and mortality in predominantly white populations. We examined the association between AACs (asthma, hay fever, or allergy) and CRC among white, African-American, Native Hawa...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu361

    authors: Tambe NA,Wilkens LR,Wan P,Stram DO,Gilliland F,Park SL,Cozen W,Martínez-Maza O,Le Marchand L,Henderson BE,Haiman CA

    更新日期:2015-06-01 00:00:00

  • The changing epidemiologic pattern of hepatitis A infection in urban Greece.

    abstract::The point prevalence of antibody to hepatitis A virus (anti-HAV) in a sample of 1,113 healthy Greek children and adolescents 0-19 years old was estimated by radioimmunoassay. The overall anti-HAV prevalence was 8.7%; it increased from almost zero among children less than four years of age to 16.3% in adolescents 15-19...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113937

    authors: Kremastinou J,Kalapothaki V,Trichopoulos D

    更新日期:1984-11-01 00:00:00

  • Twin membership and breast cancer risk.

    abstract::Pregnancy estrogens are substantially elevated in twin pregnancies and are likely to be more so in the case of dizygotic twins. If levels of pregnancy estrogens were positively related to breast cancer risk in the offspring, female twin members would be expected to be at slightly higher risk. Data from an internationa...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116444

    authors: Hsieh CC,Lan SJ,Ekbom A,Petridou E,Adami HO,Trichopoulos D

    更新日期:1992-12-01 00:00:00

  • Alcohol consumption and coronary heart disease morbidity and mortality.

    abstract::Alcohol consumption is associated with a reduced risk of coronary heart disease (CHD) but an increased risk of other causes of morbidity and mortality. It remains unclear whether there is an upper limit to a protective effect of alcohol intake on CHD risk. Whether there is a U- or an L-shaped relation between alcohol ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009303

    authors: Rehm JT,Bondy SJ,Sempos CT,Vuong CV

    更新日期:1997-09-15 00:00:00

  • The risks of cancers of the colon and rectum in relation to coffee consumption.

    abstract::To assess whether recent coffee consumption is related to the incidence of large bowel cancer, the authors analyzed data from a multipurpose hospital-based case-control study of several cancers, conducted from 1978 to 1986 in Boston, Massachusetts, New York, New York, Philadelphia, Pennsylvania, and Baltimore, Marylan...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115422

    authors: Rosenberg L,Werler MM,Palmer JR,Kaufman DW,Warshauer ME,Stolley PD,Shapiro S

    更新日期:1989-11-01 00:00:00

  • Risk of Hospitalization for Cancer, Musculoskeletal Disorders, Injuries, or Poisonings Surrounding Widowhood.

    abstract::Psychological distress has been indicated to affect the risk of death from cardiovascular disease, cancer, and external causes. Mortality from these major causes of death is also known to be elevated after widowhood when distress is at a heightened level. Surprisingly little is known about changes in health other than...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwy184

    authors: Einiö E,Martikainen P

    更新日期:2019-01-01 00:00:00

  • Detection of hepatitis B virus DNA in asymptomatic hepatitis B surface antigen carriers: relation to sexual transmission.

    abstract::The authors tested, by molecular hybridization, for hepatitis B virus DNA in serum specimens of 182 asymptomatic hepatitis B surface antigen (HBsAg) Greek carriers who were heterosexual partners of patients with acute hepatitis B (group A: 96 cases) or healthy subjects who were susceptible to hepatitis B (group B: 86 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114698

    authors: Tassopoulos NC,Papaevangelou GJ,Roumeliotou-Karayannis A,Ticehurst JR,Feinstone SM,Purcell RH

    更新日期:1987-10-01 00:00:00

  • Epidemiology of salmonellosis in California, 1990-1999: morbidity, mortality, and hospitalization costs.

    abstract::Salmonella is a common cause of bacterial foodborne illness in the United States. The epidemiology and costs of nontyphoidal salmonellosis in California from 1990 through 1999 are described using surveillance, hospitalization, and death data. Trends in Salmonella rates and factors associated with prolonged hospitaliza...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf155

    authors: Trevejo RT,Courtney JG,Starr M,Vugia DJ

    更新日期:2003-01-01 00:00:00

  • Nutrient sources in the American diet: quantitative data from the NHANES II survey. I. Vitamins and minerals.

    abstract::Dietary data from 11,658 adult respondents in the second National Health and Nutrition Examination Survey were used to provide quantitative information regarding the contribution of specific foods to the total population intake of the following 10 nutrients: vitamin A, thiamine, riboflavin, niacin, vitamin C, iron, ph...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114072

    authors: Block G,Dresser CM,Hartman AM,Carroll MD

    更新日期:1985-07-01 00:00:00

  • Associations of Tai Chi, walking, and jogging with mortality in Chinese men.

    abstract::Moderate-intensity exercise has attracted considerable attention because of its safety and many health benefits. Tai Chi, a form of mind-body exercise that originated in ancient China, has been gaining popularity. Practicing Tai Chi may improve overall health and well-being; however, to our knowledge, no study has eva...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt050

    authors: Wang N,Zhang X,Xiang YB,Li H,Yang G,Gao J,Zheng W,Shu XO

    更新日期:2013-09-01 00:00:00

  • Early life financial adversity and respiratory function in midlife: a prospective birth cohort study.

    abstract::Data from the 1958 National Child Development Study (1958-2004) were used in a prospective study of the relation of financial adversity in childhood to lung function in midlife. It was hypothesized that such a relation would be found and would be mediated partly by early housing deprivation, partly by continuities in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr284

    authors: Bartley M,Kelly Y,Sacker A

    更新日期:2012-01-01 00:00:00

  • Mental function following scalp irradiation during childhood.

    abstract::Between 1950 and 1960 about 20,000 israeli children were treated for tinea capitis by x-ray therapy as part of a large public health campaign to eradicate the disease. Dosimetric studies determined that these children were subjected to a mean brain dose of 130 rads. Almost 20 years later, possible radiation effects on...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113389

    authors: Ron E,Modan B,Floro S,Harkedar I,Gurewitz R

    更新日期:1982-07-01 00:00:00