Abstract：
:The relationship between cigarette smoking and risk of cervical neoplasia was evaluated in a case-control study of 183 women with cervical intraepithelial neoplasia compared with 183 age-matched outpatient controls, and of 230 cases of invasive cervical cancer compared with 230 controls in hospital for acute conditions unrelated to any of the identified or suspected risk factors for cervical cancer. Current cigarette smoking was associated with an elevated risk of cervical intraepithelial neoplasia (relative risk = 1.76, 95 per cent confidence interval = 1.14-2.27) and of invasive cancer (relative risk = 1.69, 95 per cent confidence interval = 1.08-2.65). This association was only partially accounted for by a large number of identified potential confounding factors, including indicators of socioeconomic status and sexual habits. The risk increased with the number of cigarettes smoked and was apparently greater for women who started smoking at younger ages. The relative risk of intraepithelial neoplasia was elevated within 20 years after the start of smoking and showed little tendency to increase with increasing duration. On the other hand, the risk of invasive cervical cancer was apparently unaffected by smoking less than 20 years and increased steadily thereafter, reaching a point estimate of 3.63 after 40 years or more. If one assumes that intraepithelial neoplasia is an early stage of cervical cancer, this pattern of risk is consistent with the predictions from the multistage theory of carcinogenesis, if the effect of smoking is on one of the earlier stages. No obvious distorting factors, apart from the play of chance, is likely to produce such a risk pattern.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
La Vecchia C,Franceschi S,Decarli A,Fasoli M,Gentile A,Tognoni Gdoi
10.1093/oxfordjournals.aje.a114220subject
Has Abstractpub_date
1986-01-01 00:00:00pages
22-9issue
1eissn
0002-9262issn
1476-6256journal_volume
123pub_type
杂志文章abstract：:Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisom...
journal_title：American journal of epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1093/aje/kwi174
更新日期：2005-07-15 00:00:00
abstract：:The aims of this prospective cohort study were to determine rates of premenopausal and early postmenopausal bone loss, age at onset of bone loss, and whether rates of bone loss depend on baseline bone mineral density (BMD). The cohort of 614 women aged 24-44 years at baseline from the longitudinal Michigan Bone Health...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwf049
更新日期：2002-09-01 00:00:00
abstract：:Studies have provided evidence of an inverse association between atopic allergic conditions (AACs) and invasive colorectal cancer (CRC) incidence and mortality in predominantly white populations. We examined the association between AACs (asthma, hay fever, or allergy) and CRC among white, African-American, Native Hawa...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwu361
更新日期：2015-06-01 00:00:00
abstract：:Homeownership is consistently associated with better mental health, but whether becoming a homeowner in later in life has positive psychological benefits has not, to our knowledge, been examined. We assessed whether acquiring a home after age 50 years was associated with depression in a representative sample of older ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwx278
更新日期：2018-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi274
更新日期：2005-10-15 00:00:00
abstract：:Although there has been a rapid rise in the publication of meta-analyses of genetic association studies, little is known about their methodological quality. The authors reviewed the quality of 120 randomly selected genetic meta-analyses published between 2005 and 2007. Data extracted included issues of general relevan...
journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/aje/kwp350
更新日期：2009-12-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/aje/kwn218
更新日期：2008-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwn395
更新日期：2009-04-01 00:00:00
abstract：:Evidence suggests a role for progesterone in ovarian cancer development. Progesterone exerts its effect on target cells by interacting with its receptor. Thus, genetic variations that may cause alterations in the biologic functions of the progesterone receptor can potentially contribute to individual susceptibility to...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi064
更新日期：2005-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010129
更新日期：2000-05-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwf037
更新日期：2002-08-01 00:00:00
abstract：:The state of pneumococcal carriage-that is, pneumococcal colonization in the nasopharynx of healthy persons-represents a reservoir for the spread of pneumococci among individuals. In light of the introduction of new pneumococcal conjugate vaccines, further knowledge on the dynamics of pneumococcal carriage is importan...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp351
更新日期：2010-01-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112897
更新日期：1980-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010149
更新日期：2000-06-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113598
更新日期：1983-06-01 00:00:00
abstract：:Previous studies suggest that birth weight and weight gain during the first year of life are related to later risk of type 1 diabetes. The authors performed a systematic review and meta-analysis on these associations. Twelve studies involving 2,398,150 persons of whom 7,491 had type 1 diabetes provided odds ratios and...
journal_title：American journal of epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1093/aje/kwp065
更新日期：2009-06-15 00:00:00
abstract：:Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationall...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm075
更新日期：2007-08-01 00:00:00
abstract：:Populations of Mexican descent have high occurrences of neural tube defects (NTDs). A recent study suggested that folic acid supplements may not protect these populations from NTDs. In a case-control study, the authors investigated the role of folic acid and dietary folate intake in NTD risk among Mexican Americans li...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/152.11.1017
更新日期：2000-12-01 00:00:00
abstract：:A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases -- 377 with cleft lip with or without cleft palate and 196 with cleft palate only -- and 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containi...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp040
更新日期：2009-05-15 00:00:00
abstract：:Sizes at birth of parents and their children are known to be correlated, reflecting in part the influence of fetal and maternal genes. Sociodemographic factors, regarded as aspects of the shared environment across generations, would also be expected to contribute, but evidence is limited. In the present study, the aut...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr032
更新日期：2011-07-01 00:00:00
abstract：:Breast cancer is diagnosed at a younger age and a more advanced stage in African-American women than in White women. The authors investigated the effects of several factors, including race, on stage of breast cancer in women aged 20-54 years living in Atlanta, Georgia, and diagnosed between 1990 and 1992. A total of 2...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm177
更新日期：2007-11-01 00:00:00
abstract：:The size of a person's social network is linked to health and longevity, but it is unclear whether the number of strong social ties or the number of weak social ties is most influential for health. We examined social network characteristics as predictors of mortality in the Finnish Public Sector Study (n = 7,617) and ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwx301
更新日期：2018-04-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm148
更新日期：2007-10-01 00:00:00
abstract：:The identification of the environmental factors causing insulin-dependent diabetes in children has remained elusive. However, evidence is rapidly accumulating that childhood diabetes exhibits epidemic patterns, much like that seen with an infectious disease. It is likely that within these epidemics the environmental d...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Benign breast disease is associated with increased risk of breast cancer. To further clarify whether there is a genetic link between benign and malignant breast lesions, the authors identified 14,648 first-degree female relatives of 8,807 patients in whom breast cancer was diagnosed at <50 years of age by using Danish...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwn133
更新日期：2008-08-01 00:00:00
abstract：:In a case-control study conducted in 1978 in Detroit, Michigan, as part of the National Bladder Cancer Study, the proportions of artificial sweetener users in a hospital and a population control series were compared. The study was based on interviews with 305 hospital controls and 440 population controls, as well as 3...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113545
更新日期：1983-03-01 00:00:00
abstract：:This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed bet...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117297
更新日期：1994-10-01 00:00:00
abstract：:In the Smokers and Nonsmokers Study, the authors investigated the feasibility of using random digit dialing telephone interviews to locate adults in the continental United States who were willing to provide DNA from buccal swabs through the mail. Interviews with 3,383 adults regarding their smoking-related behaviors (...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwf010
更新日期：2002-07-01 00:00:00
abstract：:The relation between allergy and risk of cancer was evaluated in a cohort study of 34,198 Seventh-day Adventists in California. Information on prevalence of asthma, hay fever, and reactions to chemicals, medications, bee stings, and poison oak (or ivy) was obtained by questionnaire in 1976. The reported allergies must...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116494
更新日期：1992-08-01 00:00:00
abstract：:The authors aimed to quantify the effects of current systolic blood pressure (SBP) and serum total cholesterol on the risk of mortality in comparison with SBP or serum cholesterol 25 years previously, taking measurement error into account. The authors reanalyzed 35-year follow-up data on mortality due to coronary hear...
journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/aje/kwk021
更新日期：2007-02-15 00:00:00
