Abstract：
:Although there has been a rapid rise in the publication of meta-analyses of genetic association studies, little is known about their methodological quality. The authors reviewed the quality of 120 randomly selected genetic meta-analyses published between 2005 and 2007. Data extracted included issues of general relevance and other issues specific to genetic epidemiology. Quality was markedly poorer in the 26% of the meta-analyses that accompanied a report on a primary study. Such meta-analyses were predominantly published in specialist journals, and their quality was positively associated with the impact factor of the journal. Among the meta-analyses that did not accompany a primary study, Human Genome Epidemiology reviews tended to score better than the others, although the comparison was limited by relatively small numbers. Comparison of the overall quality with that of genetic meta-analyses published before 2000 showed improvement in both conduct and reporting. However, the quality of the handling of specific genetic issues remains disappointingly low. For a few key general quality issues, the authors compared their findings with findings in other fields of medicine and found that general quality was similar. On the basis of this review, the authors provide practical recommendations for the conduct and reporting of genetic meta-analyses.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Minelli C,Thompson JR,Abrams KR,Thakkinstian A,Attia Jdoi
10.1093/aje/kwp350subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1333-43issue
11eissn
0002-9262issn
1476-6256pii
kwp350journal_volume
170pub_type
杂志文章,评审abstract：:Case-control differences in prediagnostic serum levels of retinol, beta-carotene, vitamin E, and selenium are compared for 10 cancer sites in 10 study populations. For all four nutrients, the majority of results showed lower levels among persons who subsequently became cases than among controls. Low levels of beta-car...
journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,评审
doi：10.1093/oxfordjournals.aje.a116264
更新日期：1992-01-15 00:00:00
abstract：:The link between blood pressure measured at juvenile ages (3-18 years) and subsequent adult ages (30 and 50 years) was investigated in a community-based longitudinal study conducted in the San Francisco Bay Area from 1928 to the present. The original sample of 550 persons decreased 61 percent by age 50 years, leaving ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116543
更新日期：1992-09-15 00:00:00
abstract：:In a 1995-1996 cohort study in the city of Dhaka, Bangladesh, morbidity in 117 hospitalized and 137 acute measles cases compared with age-matched children without measles (unexposed) was determined by weekly interview for 6 months. Compared with unexposed children, there were higher incidences of hospitalization (adju...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010267
更新日期：2000-04-01 00:00:00
abstract：:Investigations of gene (G)-environment (E) interactions have led to limited findings to date, possibly due to weak effects of individual genetic variants. Polygenic risk scores (PRS), which capture the genetic susceptibility associated with a set of variants, can be a powerful tool for detecting global patterns of int...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwz175
更新日期：2019-11-01 00:00:00
abstract：:The authors evaluated the association of complexity of work with data, people, and things with the incidence of dementia, Alzheimer's disease, and vascular dementia in the Canadian Study of Health and Aging, while adjusting for work-related physical activity. The Canadian Study of Health and Aging is a 10-year populat...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm382
更新日期：2008-04-01 00:00:00
abstract：:Evidence concerning the role of Helicobacter pylori infection in the development of colorectal cancer remains controversial. The authors assessed the association of H. pylori seroprevalence with risk of colorectal cancer in a large population-based case-control study from Germany in 2003-2007. Serum antibodies to H. p...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr331
更新日期：2012-03-01 00:00:00
abstract：:Male drivers sustained relatively more serious motorcycle collision injuries than did male passengers, female drivers, or female passengers. For male drivers, severity of injury was related to age. The relative frequency of serious head injury was highest for drivers not wearing helmets who were involved in collisions...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112137
更新日期：1975-07-01 00:00:00
abstract：:During the period from September 8 to October 2, 1970, 44 of the 120 children and 78 of 141 adults questioned at the Children's Asthma Research Institute and Hospital experienced gastroenteritis characterized by nausea, vomiting, and fever and/or chills. Diarrhea was rare in children (4.5%) and common in adults (74%)....
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112154
更新日期：1975-09-01 00:00:00
abstract：:The analysis of the combined effects of nutritional factors with other putative disease determinants in log-linear or logistic models is methodologically complicated by the strong multicollinearity between nutritional factors, resulting in poor precision in estimating the parameters. Furthermore, the generally used mu...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117572
更新日期：1995-12-01 00:00:00
abstract：:Studies from the United States have shown increasing incidence of autism spectrum disorder (ASD) with increasing socioeconomic status (SES), whereas in Scandinavian countries, no such relation was identified. We investigated how ASD risk in offspring varied according to parental SES in Taiwan, where we have universal ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwaa241
更新日期：2020-10-31 00:00:00
abstract：:Second-generation assays for anti-cyclic citrullinated peptide (anti-CCP), a highly sensitive and specific marker for rheumatoid arthritis (RA), have redefined the epidemiology of RA. In the Women's Health Initiative (WHI) RA study (2009-2011), we evaluated the prevalence of anti-CCP positivity among 15,691 (10.2% of ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwu003
更新日期：2014-04-01 00:00:00
abstract：:Chronic obstructive pulmonary disease is known to be associated with systemic inflammation. We examined the longitudinal association of C-reactive protein (CRP) and lung function in a cohort of 18,110 men and women from the European Prospective Investigation Into Cancer in Norfolk who were 40-79 years of age at baseli...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwt208
更新日期：2014-01-01 00:00:00
abstract：:Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and sm...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr124
更新日期：2011-09-01 00:00:00
abstract：:Vaccinating school-aged children against influenza can reduce age-specific and population-level illness attack rates. Using a stochastic simulation model of influenza transmission, the authors assessed strategies for vaccinating children in the United States, varying the vaccine type, coverage level, and reproductive ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp237
更新日期：2009-09-15 00:00:00
abstract：:This paper describes the Observing Protein and Energy Nutrition (OPEN) Study, conducted from September 1999 to March 2000. The purpose of the study was to assess dietary measurement error using two self-reported dietary instruments-the food frequency questionnaire (FFQ) and the 24-hour dietary recall (24HR)-and unbias...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwg092
更新日期：2003-07-01 00:00:00
abstract：:In systematic studies of the molecular epidemiology of tuberculosis, DNA fingerprinting is used to estimate the fraction of incident cases attributable to recent transmission of Mycobacterium tuberculosis rather than reactivation disease and to identify risk factors for recent transmission. This approach is based on t...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/155.6.565
更新日期：2002-03-15 00:00:00
abstract：:A retrospective cohort study of workers exposed to phenoxy herbicides, chlorophenols, and contaminants (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other polychlorinated dioxins and furans) has been conducted in a chemical factory in the Netherlands. Male workers exposed to phenoxy herbicides or chlorophenols showe...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009543
更新日期：1998-05-01 00:00:00
abstract：:Eighty-eight cases with newly diagnosed carcinoma of the endometrium and 177 age-matched neighborhood controls were interviewed to test the hypothesis that exogenous estrogens lead to an increased risk of endometrial cancer. Forth-five per cent of the cases and 22% of the controls reported a history of estrogen use wh...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113215
更新日期：1981-10-01 00:00:00
abstract：:Researchers have failed to find a consistent association between childhood victimization and vulvodynia, a debilitating, unexplained vulvar pain condition. However, selection bias associated with case ascertainment, and differential reporting bias between clinic-based cases and controls, may explain in part the incons...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi108
更新日期：2005-05-01 00:00:00
abstract：:In the absence of strong assumptions (e.g., exchangeability), only bounds for causal effects can be identified. Here we describe bounds for the risk difference for an effect of a binary exposure on a binary outcome in 4 common study settings: observational studies and randomized studies, each with and without simple r...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwz060
更新日期：2019-07-01 00:00:00
abstract：:Recently, the focus of research on cardiovascular risk factors has broadened because of new data demonstrating benefits of low risk (i.e., favorable) levels of all major modifiable risk factors. Most data on low risk relate to coronary heart disease, not stroke. This population-based, 12-sample, Italian study (Progett...
journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/aje/kwj110
更新日期：2006-05-15 00:00:00
abstract：:Rabies virus was isolated by cell culture from the brains of 104 confirmed rabies cases diagnosed by the fluorescent-antibody staining technique in the United States during 1974-1984. Eighty-seven isolates were obtained from wild-life species, 10 from humans, and seven from domestic animals. These isolates were tested...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/126.2.298
更新日期：1987-08-01 00:00:00
abstract：:A consistent framework has been developed for measuring health disparities and making comparisons across indicators with regard to the public health goals of Healthy People 2010. Disparities are measured as the percent difference from the best group rate, with all indicators being expressed in terms of adverse events....
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm044
更新日期：2007-07-01 00:00:00
abstract：:Larger body size in childhood is correlated with earlier age at menarche; whether birth and infant body size changes are also associated with age at menarche is less clear. The authors contacted female participants enrolled in the New York site of the US National Collaborative Perinatal Project born between 1959 and 1...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp095
更新日期：2009-07-01 00:00:00
abstract：:The relationship between cigarette smoking and risk of cervical neoplasia was evaluated in a case-control study of 183 women with cervical intraepithelial neoplasia compared with 183 age-matched outpatient controls, and of 230 cases of invasive cervical cancer compared with 230 controls in hospital for acute condition...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114220
更新日期：1986-01-01 00:00:00
abstract：:Although randomized controlled trials are regarded as the gold standard for comparison of treatments, evidence from observational studies is still relevant. To cope with the problem of possible confounding in these studies, investigators need methods for analyzing their results which adjust for confounders and lead to...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwn010
更新日期：2008-05-01 00:00:00
abstract：:An analysis of the familial aggregation of blood pressure (BP) was conducted to provide estimates of the role of genes and household environment in determining the phenotypic resemblance between biologically related family members. The biological model used for this analysis parameterizes the correlations between fami...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112830
更新日期：1979-10-01 00:00:00
abstract：:Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military p...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp238
更新日期：2009-10-15 00:00:00
abstract：:The authors examined the relation between 50 widely used agricultural pesticides and lung cancer incidence in the Agricultural Health Study, a prospective cohort study of 57,284 pesticide applicators and 32,333 spouses of farmer applicators with no prior history of lung cancer. Self-administered questionnaires were co...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh290
更新日期：2004-11-01 00:00:00
abstract：:Associations of gaseous air pollutants (including carbon monoxide, sulfur dioxide, nitrogen dioxide, and ozone) with asthma hospitalization, stratified by sex and socioeconomic status, were examined among children 6-12 years of age in Vancouver, British Columbia, Canada, between 1987 and 1998. Relative risks for an ex...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh043
更新日期：2004-02-01 00:00:00
