Abstract：
:Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationally representative survey, the authors explored Black/White differences in serum selenium concentration. Mean serum selenium concentrations, both crude and adjusted for known predictors of serum selenium, were determined for 10,779 Black and White males and females aged >or=12 years who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Crude mean serum selenium concentrations were 126.35 ng/ml for Whites and 118.76 ng/ml (approximately 6% lower) for Blacks. Adjustment for known serum selenium predictors, including a proxy for residence at the county level, reduced the racial disparity, although concentrations remained approximately 3% lower in Blacks than in Whites of both sexes (p<0.0001). The observation that Blacks had lower unadjusted and adjusted serum selenium concentrations relative to Whites is intriguing, given the racial disparity in incidence of prostate cancer and other cancers.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Vogt TM,Ziegler RG,Patterson BH,Graubard BIdoi
10.1093/aje/kwm075subject
Has Abstractpub_date
2007-08-01 00:00:00pages
280-8issue
3eissn
0002-9262issn
1476-6256pii
kwm075journal_volume
166pub_type
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