Abstract：
:Benign breast disease is associated with increased risk of breast cancer. To further clarify whether there is a genetic link between benign and malignant breast lesions, the authors identified 14,648 first-degree female relatives of 8,807 patients in whom breast cancer was diagnosed at <50 years of age by using Danish nationwide cancer and population registers. Hospital register data were used to follow the relatives for occurrence of benign breast disease from 1977 to 2003 and to calculate rates of benign breast disease in the general population of Danish women for comparison. Risk for relatives was increased for benign breast diseases (observed/expected ratio = 1.54, 95% confidence interval: 1.42, 1.66), particularly for relatives aged <40 years. Higher risks were observed after breast cancer had been diagnosed in the family; however, an increased risk for relatives aged <50 years (observed/expected ratio = 1.24, 95% confidence interval: 1.02, 1.51) was present before breast cancer was diagnosed in the family. Enhanced surveillance of close relatives of breast cancer patients seems to be an important factor to address when investigating the association between benign breast disease and familial breast cancer. A genetic link between benign breast disease and breast cancer was indicated by our data but needs to be confirmed in future studies.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Bertelsen L,Mellemkjaer L,Balslev E,Olsen JHdoi
10.1093/aje/kwn133subject
Has Abstractpub_date
2008-08-01 00:00:00pages
261-7issue
3eissn
0002-9262issn
1476-6256pii
kwn133journal_volume
168pub_type
杂志文章abstract：:Prolonged sitting time is associated with several health outcomes; limited evidence indicates associations with frailty. Our aims in this study were to identify patterns of sitting time over 12 years in middle-aged (ages 50-55 years) women and examine associations of these patterns with frailty in older age. We examin...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1976-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-05-01 00:00:00
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更新日期：2007-08-01 00:00:00
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更新日期：2016-09-15 00:00:00
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更新日期：2019-02-01 00:00:00
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更新日期：2004-12-01 00:00:00
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更新日期：2014-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112482
更新日期：1977-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2015-10-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2002-11-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,meta分析,评审
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更新日期：2008-01-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1976-06-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1992-02-01 00:00:00
abstract：:Since June 1982, the Wisconsin Chronic Renal Disease Program has provided reimbursement for hepatitis B virus vaccine and pre- and postvaccine serologic testing for patients and staff in all Wisconsin renal dialysis centers. Between July 1, 1982 and June 30, 1984, 444 dialysis patients in 22 renal dialysis centers and...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1988-04-01 00:00:00
