Abstract:
:Risk factors for fibroadenoma were examined in a case-control study involving 117 fibroadenoma cases ascertained by a major private pathology laboratory in Adelaide, Australia, between January 1983 and October 1985. For each case a population control was randomly selected from the electoral roll in Adelaide and matched to the corresponding case by sex, age, and socioeconomic grading of area of residence. Another 189 women whose first biopsy for benign breast disease was examined in the same laboratory during the same time period as those of the cases, but did not show evidence of epithelial proliferation, were also included in the study as a biopsy control group. Risk of fibroadenoma was associated inversely with the Quetelet index, but there was no evidence of an association with age at menarche or menopausal status. The risk of fibroadenoma decreased with an increasing number of full-term pregnancies and was increased in association with use of oral contraceptives at an early age (under 20 years); however, these two associations were observed only when cases were compared with the population controls. Alcohol consumption and dietary fat intake were found not to be associated with altered risk of fibroadenoma, while in multivariate analyses, duration of cigarette smoking and daily vitamin C intake were both shown to have inverse associations with risk of fibroadenoma. Although fibroadenoma does share some risk factors with breast cancer, there is insufficient evidence to suggest that it represents a precursor state.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Yu H,Rohan TE,Cook MG,Howe GR,Miller ABdoi
10.1093/oxfordjournals.aje.a116278subject
Has Abstractpub_date
1992-02-01 00:00:00pages
247-58issue
3eissn
0002-9262issn
1476-6256journal_volume
135pub_type
杂志文章abstract::Regression equations, based on scutal index (body length/scutal width), were developed to determine the duration of attachment for nymphal and adult female lxodes scapularis ticks. Feeding times were calculated for 444 nymphal and 300 female ticks submitted by bite victims between 1985 and 1989 in Westchester County, ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008728
更新日期:1996-01-15 00:00:00
abstract::The relationship between cataract prevalence, altitude, and sunlight hours was investigated in a large national probability sample survey of 105 sites in the Himalayan kingdom of Nepal, December 1980 through April 1981. Cataract of senile or unknown etiology was diagnosed by ophthalmologists in 873 of 30,565 full-time...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113632
更新日期:1983-08-01 00:00:00
abstract::The ratio of cancer occurrence among smokers compared to nonsmokers has been generally reported to be greatest for carcinomas arising in the lung and larynx. This report presents the results of an investigation into mechanisms underlying the temporal trends in the incidence of these two forms of cancer in Scotland ove...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114585
更新日期:1987-04-01 00:00:00
abstract::1,3-Butadiene and styrene are suspected carcinogens and common chemicals used in the synthesis of rubber. To investigate any potential human hazards from exposure to these chemicals, a case-control study of 59 lymphohematopoietic cancers was conducted within a cohort of male workers employed between 1943 and 1982 in e...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/136.7.843
更新日期:1992-10-01 00:00:00
abstract::The authors assessed the association between cognitive function and incidence and maintenance of overweight in preschool children. A population-based birth cohort was established in Menorca, Spain, between 1997 and 1999 (n = 482). Body mass index (weight (kg)/height (m)(2)) was measured at ages 4 years and 6 years (n ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp140
更新日期:2009-08-15 00:00:00
abstract::The Mental Function Index is a weighted combination of scores on three brief tests. The Index was developed to aid in the discrimination of elderly persons with early cases of senile dementia from nondemented elderly individuals. In a previous report (Am J Epidemiol 1981;114:515-27), the authors described preliminary ...
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113963
更新日期:1984-12-01 00:00:00
abstract::Several investigators have observed an association between alcohol consumption and elevated glucose levels, raising the possibility that alcohol may increase the risk of diabetes. This hypothesis was evaluated prospectively among 85,051 women participating in the Nurses' Health Study who were 34 to 59 years of age in ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115002
更新日期:1988-09-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/145.8.738
更新日期:1997-04-15 00:00:00
abstract::There is a paucity of data on basal-cell carcinoma (BCC) in the United States, since most national registries do not collect information on BCC. We evaluated BCC incidence trends and associated risk factors for BCC in 140,171 participants from a U.S. female cohort, the Nurses' Health Study (1986-2006), and a U.S. male...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt073
更新日期:2013-09-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn390
更新日期:2009-03-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116444
更新日期:1992-12-01 00:00:00
abstract::Epidemiologic research that uses administrative records (rather than registries or clinical surveys) to identify cases for study has been increasingly restricted because of concerns about privacy, making unbiased population-based research less practicable. In their article, Nattinger et al. (Am J Epidemiol. 2010;172(6...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwq219
更新日期:2010-09-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv168
更新日期:2016-01-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwk106
更新日期:2007-04-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117653
更新日期:1995-08-15 00:00:00
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journal_title:American journal of epidemiology
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更新日期:2000-10-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm308
更新日期:2008-02-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy248
更新日期:2019-03-01 00:00:00
abstract::Research on inflammatory bowel disease risk among oral contraceptive users has reached conflicting conclusions. This population-based case-control study evaluated the effects of oral contraceptive use on ulcerative colitis and Crohn's disease risk. Cases were women enrollees, aged 15-68 years, of Group Health Cooperat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117246
更新日期:1994-08-01 00:00:00
abstract::This paper addresses the use of epidemiologic evidence when a cluster becomes the focus of dispute in court. It is often difficult to prove by a preponderance of the evidence that an exposure for which a defendant is responsible caused the disease or diseases at issue. Thus, in a number of cases plaintiffs have resort...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115793
更新日期:1990-07-01 00:00:00
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更新日期:2007-02-01 00:00:00
abstract::The loss of CD4 lymphocytes is known to be an important component of human immunodeficiency virus type 1 (HIV-1) pathogenesis. It remains unclear, however, whether the importance of the CD4 lymphocyte count is such that individuals who have been infected for widely different lengths of time, but for whom the CD4 lymph...
journal_title:American journal of epidemiology
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更新日期:1993-11-15 00:00:00
abstract::The authors performed a meta-analysis to estimate the magnitude of polymorphism effects for the complement component C3 gene (C3) and their possible mode of action on age-related macular degeneration (AMD). The meta-analysis included 16 and 7 studies for rs2230199 and rs1047286, respectively. Data extraction and risk ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/aje/kwr025
更新日期:2011-06-15 00:00:00
abstract::Ninety-four strains of Venezuelan encephalitis (VE) virus isolated from sentinel hamsters exposed in the Middle American countries of Mexico, Guatemala, Belize, and Honduras were examined for the presence of virions with marker characteristics of strains that cause large epidemics and equine epizootics. Thirty-four st...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113531
更新日期:1983-02-01 00:00:00
abstract::Cigarette smoking during pregnancy is an important, avoidable factor associated with low birth weight. Maternal age is also associated with variations in birth weight. Using birth certificate data from all 347,650 singleton births for which maternal age and birth weight were recorded during 1984-1988 in Washington Sta...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116940
更新日期:1994-05-15 00:00:00
abstract::Highly active antiretroviral therapy (HAART) has been shown to be effective in different populations, but data among injection drug users are limited. Human immunodeficiency virus-infected injection drug users recruited into the Acquired Immunodeficiency Syndrome Link to Intravenous Experiences (ALIVE) Study as early ...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章
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更新日期:2005-06-01 00:00:00
abstract::Two families of gorillas, comprising 13 animals, were studied in 1980-1982 for hepatitis virus infections. It was found that 27% of them had evidence of hepatitis B infection, and 23% evidence of hepatitis A infection. The four parents had been born in the wild and all of them had been infected with hepatitis B. The t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113760
更新日期:1984-03-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009523
更新日期:1998-04-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008951
更新日期:1996-09-01 00:00:00