Abstract：
:The Mental Function Index is a weighted combination of scores on three brief tests. The Index was developed to aid in the discrimination of elderly persons with early cases of senile dementia from nondemented elderly individuals. In a previous report (Am J Epidemiol 1981;114:515-27), the authors described preliminary results with the Index in 195 elderly persons in a southern California retirement community. The present study seeks to assess whether similar results can be achieved in samples other than that from which the discriminant function defining the Index was derived. Seven separate studies were done on a total of 210 persons, comprising subjects recruited from a teaching hospital which serves a predominantly lower to lower-middle class population, referrals from the same physicians as in the earlier study, and (for the reliability sample) persons from the upper-middle class community which was the major referral source. It was found that scores on the brief measures correlate 0.86 with those on the three Halstead-Reitan subtests most sensitive to brain damage and to aging. The Index provides a graded measure of disease severity comparable to global neurologic assessment (r = -0.84) and level of social function (r = 0.76). Entry Index is a crude predictor of cognitive status in older adults after several years. Changes in the Index over time parallel those in independent measures of change. The results suggest that the Index will be useful for assessment of disease severity and of longitudinal change, as well as for diagnostic screening, in population studies of senile dementia.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Pfeffer RI,Kurosaki TT,Chance JM,Filos S,Bates Ddoi
10.1093/oxfordjournals.aje.a113963subject
Has Abstractpub_date
1984-12-01 00:00:00pages
922-35issue
6eissn
0002-9262issn
1476-6256journal_volume
120pub_type
杂志文章abstract：:The relation between the risk of breast cancer before 45 years of age and oral contraceptive use was examined in a case-control study conducted in New York, Philadelphia, Baltimore, and Boston from 1983 to 1986 of 407 patients with breast cancer and 424 controls. With allowance for confounding, for ever use, the multi...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115132
更新日期：1989-02-01 00:00:00
abstract：:Investigations of gene (G)-environment (E) interactions have led to limited findings to date, possibly due to weak effects of individual genetic variants. Polygenic risk scores (PRS), which capture the genetic susceptibility associated with a set of variants, can be a powerful tool for detecting global patterns of int...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwz175
更新日期：2019-11-01 00:00:00
abstract：:The study investigated the prevalence of antibodies to five leading agents of childhood respiratory disease in the county of Huixquilucan, Mexico. Tests of sera from a random sample of children between 3 months and 18 years of age confirmed serologically the presence of Mycoplasma pneumoniae, respiratory syncytial (RS...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112113
更新日期：1975-05-01 00:00:00
abstract：:This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114854
更新日期：1988-04-01 00:00:00
abstract：:The associations between alcohol consumption and cigarette smoking habits and the risk for colorectal adenomatous polyps according to the detailed clinical information about polyps were assessed in a large colonoscopy-based study. The study enrolled participants who visited the National Cancer Center of the Republic o...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr098
更新日期：2011-09-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh073
更新日期：2004-03-15 00:00:00
abstract：:Buccal cells provide a convenient source of DNA for epidemiologic studies. Mouthwash rinses yield a higher quality and quantity of DNA than cytobrushes but are not practical for collection from infants. Although cytobrushes yield sufficient DNA for most genotyping analyses, human leukocyte antigen (HLA) analysis can r...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh171
更新日期：2004-07-01 00:00:00
abstract：:The objective of this study was to evaluate and compare risk factor patterns in association with preeclampsia and gestational hypertension. The data were collected from The Swedish Medical Birth Register and include all nulliparas aged 34 years or less who gave birth at the University Hospital of Uppsala, Sweden, duri...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009400
更新日期：1998-06-01 00:00:00
abstract：:While time-series studies have consistently provided evidence for an effect of particulate air pollution on mortality, uncertainty remains as to the extent of the life-shortening implied by those associations. In this paper, the authors estimate the association between air pollution and mortality using different times...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwg087
更新日期：2003-06-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwi337
更新日期：2005-12-15 00:00:00
abstract：:Racial and ethnic differences in associations between socioeconomic position (SEP) and risk of childhood acute lymphoblastic leukemia (ALL) were investigated using data from population-based cancer registries in the Surveillance, Epidemiology, and End Results Program in the United States. The study included 8,383 ALL ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kww164
更新日期：2017-06-15 00:00:00
abstract：:Diabetes confers a higher risk of cardiovascular disease on women than on men. The reasons for these sex differences, such as poorer cardiovascular risk factor profiles, have received considerable attention. However, a recent report on sex × diabetes interactions on cardiovascular disease identified that few if any pr...
journal_title：American journal of epidemiology
pub_type： 评论,杂志文章
doi：10.1093/aje/kwx327
更新日期：2018-03-01 00:00:00
abstract：:The authors investigated families with at least one hepatitis B surface antigen (HBsAg) carried in Okinawa, Japan, to determine possible routes of hepatitis B virus transmission within family units. A total of 175 members of 37 families on the western part of Iriomote Island, Okinawa, were followed up for 2-13 years; ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113923
更新日期：1984-10-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114698
更新日期：1987-10-01 00:00:00
abstract：:An epidemic of viral hepatitis type A in an arctic area is described. From 1970-1974, 4961 clinical cases of hepatitis were reported in Greenland, corresponding to 11 per cent of the total population. Epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112366
更新日期：1977-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112715
更新日期：1979-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwu150
更新日期：2014-08-15 00:00:00
abstract：:This longitudinal study examines the transition to adulthood in a randomly sampled, community-based cohort of adolescents. The study compares young adult outcomes of 33 adolescents with and 148 adolescents without psychiatric disorder. After adjustment for differences in age, gender, and social class, adolescents with...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/152.4.352
更新日期：2000-08-15 00:00:00
abstract：:The knowledge of leprosy epidemiology is still extremely limited as to basic epidemiologic characteristics. Only the infectious agent and the reservoir of infection have been firmly established. It is all the more surprising that very few studies of analytical leprosy epidemiology are reported in the literature. In or...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114012
更新日期：1985-03-01 00:00:00
abstract：:When analyzing and interpreting data from an epidemiologic study where ordinal (ordered categorical) outcomes have been measured in different exposure groups, an effect parameter of interest is the common odds ratio implied by the proportional odds model. This model can sometimes be applied to a collapsed outcome vari...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008944
更新日期：1996-08-15 00:00:00
abstract：:This study aimed to evaluate the predictive performance of genetic risk models based on risk loci identified and/or confirmed in genome-wide association studies for type 2 diabetes mellitus. A systematic literature search was conducted in the PubMed/MEDLINE and EMBASE databases through April 13, 2012, and published da...
journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
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更新日期：2013-10-15 00:00:00
abstract：:The relation between self-reported physical activity and depressive symptoms was analyzed for 1,900 healthy subjects aged 25-77 years in the Epidemiologic Follow-up Study (1982-1984) to the first National Health and Nutrition Examination Survey (NHANES I). Depressive symptomatology as measured by the Center for Epidem...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115087
更新日期：1988-12-01 00:00:00
abstract：:Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) biomarkers. V...
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更新日期：2013-06-15 00:00:00
abstract：:The authors conducted a simulation study to examine whether the race of a patient with end-stage renal disease (ESRD) influences the diagnosis of underlying kidney disease made by the nephrologist. The hypothesis was that ESRD may be more readily ascribed to hypertension in blacks than in whites. Nephrologists practic...
journal_title：American journal of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/oxfordjournals.aje.a117338
更新日期：1995-01-01 00:00:00
abstract：:Seventh-Day Adventists in Tromsø showed a coronary risk factor pattern similar to Seventh-Day Adventists in other parts of the world. Compared with non-Seventh-Day Adventists, serum cholesterol was 1.35 mmol/liter (1974) and 0.83 mmol/liter (1979-1980) lower in males and 0.64 mmol/liter (1979-1980) lower in females. B...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114162
更新日期：1985-11-01 00:00:00
abstract：:Observational studies and randomized controlled trials of menopausal hormone therapy (HT) and chronic disease risk appear to have divergent results for cardiovascular disease. However, differences may be related to a modifying effect of age, time since menopause, and HT formulation. In the Nurses' Health Study (NHS) (...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwx131
更新日期：2017-09-15 00:00:00
abstract：:Several investigators have observed an association between alcohol consumption and elevated glucose levels, raising the possibility that alcohol may increase the risk of diabetes. This hypothesis was evaluated prospectively among 85,051 women participating in the Nurses' Health Study who were 34 to 59 years of age in ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115002
更新日期：1988-09-01 00:00:00
abstract：:The 1982-1984 Hispanic Health and Nutrition Examination Survey used ultrasonography to investigate risk factors for gallstone disease (gallstones or cholecystectomy). Mexican American, Cuban American, and Puerto Rican men (n = 968) and women (n = 1,325) aged 20-74 years were selected from household samples in nine sta...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115574
更新日期：1990-05-01 00:00:00
abstract：:According to antibody analysis, approximately two of every three intravenous drug users in Iceland have become infected with hepatitis C virus (HCV). In this study, serum samples from 55 HCV antibody-positive intravenous drug users (39 males and 16 females) were analyzed by polymerase chain reaction, and the viral str...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008793
更新日期：1996-03-15 00:00:00
abstract：:Few studies have examined the role of endogenous sex hormones in breast cancer, and to the authors' knowledge, only two have done so prospectively. The authors report here the results of a prospective study based on an available bank of previously analyzed plasma collected in 1972-1974 from 442 women aged 50-79 years ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116228
更新日期：1992-06-01 00:00:00
