Abstract：
:Several investigators have observed an association between alcohol consumption and elevated glucose levels, raising the possibility that alcohol may increase the risk of diabetes. This hypothesis was evaluated prospectively among 85,051 women participating in the Nurses' Health Study who were 34 to 59 years of age in 1980 and had no history of cancer, coronary heart disease, or diabetes. At baseline, participants completed an independently validated dietary questionnaire which included information on the consumption of beer, wine, and liquor. Incident cases of non-insulin-dependent diabetes were reported on follow-up questionnaires sent in 1982 and 1984 (98% response to at least one follow-up); 526 cases were confirmed by a supplementary questionnaire regarding symptoms, laboratory values, and treatment. The risk of diabetes decreased monotonically with increasing alcohol consumption (chi trend = -9.4, p less than 0.0001). Compared with nondrinkers, women consuming 5-14.9 g of alcohol per day (about 4-10 drinks per week) had an age-adjusted relative risk of diabetes of 0.4 (95% confidence interval (CI) 0.3-0.6); for 15 g or more per day, the relative risk was 0.3 (95% CI 0.2-0.4). However, a strong inverse association between alcohol drinking and body weight explained much of the apparent protective effect of alcohol. After simultaneous adjustment for Quetelet index (weight (kg)/height (m)2), family history of diabetes, total caloric intake, and age, the relative risk of diabetes for consumers of 5-14.9 g per day was 0.8 (95% CI 0.6-1.2), and for women who drank 15+ g per day, the relative risk was 0.6 (95% CI 0.3-0.9). These data provide no support for the hypothesis that moderate alcohol intake increases the risk of non-insulin-dependent diabetes.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Stampfer MJ,Colditz GA,Willett WC,Manson JE,Arky RA,Hennekens CH,Speizer FEdoi
10.1093/oxfordjournals.aje.a115002subject
Has Abstractpub_date
1988-09-01 00:00:00pages
549-58issue
3eissn
0002-9262issn
1476-6256journal_volume
128pub_type
杂志文章abstract：:Buccal cells provide a convenient source of DNA for epidemiologic studies. Mouthwash rinses yield a higher quality and quantity of DNA than cytobrushes but are not practical for collection from infants. Although cytobrushes yield sufficient DNA for most genotyping analyses, human leukocyte antigen (HLA) analysis can r...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh171
更新日期：2004-07-01 00:00:00
abstract：:Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to curr...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009997
更新日期：1999-08-01 00:00:00
abstract：:The purpose of this study was to assess the relation between maternal multivitamin use and risk for cardiac defects in the offspring, using a population-based approach. The Atlanta Birth Defects Case-Control study is a population-based case-control study of infants born between 1968 and 1980 to mothers residing in met...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010291
更新日期：2000-05-01 00:00:00
abstract：:The involvement of organophosphate insecticides in cognitive disorders is supported by epidemiologic and biological evidence, but the effects of long-term exposure remain debated. We studied the association between organophosphate exposure and cognitive performance in vine workers from the PHYTONER study cohort in the...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kws346
更新日期：2013-05-15 00:00:00
abstract：:A retrospective cohort study of workers exposed to phenoxy herbicides, chlorophenols, and contaminants (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other polychlorinated dioxins and furans) has been conducted in a chemical factory in the Netherlands. Male workers exposed to phenoxy herbicides or chlorophenols showe...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.aje.a114789
更新日期：1988-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.aje.a116207
更新日期：1992-05-15 00:00:00
abstract：:Breast cancer is the leading cancer diagnosed among women, and environmental studies have produced few leads on modifiable risk factors for breast cancer. Following an Institute of Medicine recommendation for occupational studies of women highly exposed to potential breast cancer risk factors, we took advantage of an ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116013
更新日期：1991-11-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2016-09-15 00:00:00
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pub_type： 评论,杂志文章
doi：10.1093/oxfordjournals.aje.a009812
更新日期：1999-02-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwt225
更新日期：2013-11-15 00:00:00
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pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009723
更新日期：1999-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm397
更新日期：2008-04-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117328
更新日期：1994-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117500
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更新日期：2005-08-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1991-09-15 00:00:00
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更新日期：1998-06-01 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2014-09-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113137
更新日期：1981-05-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2000-05-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114382
更新日期：1986-08-01 00:00:00
