Abstract:
:For diseases of well-defined genetic etiology and with onset after birth, the age at onset corresponds to the incubation period of the disease. The lognormal model, as used by Sartwell to study the distribution of incubation periods in infectious diseases (Am J Hyg 1950;51:310-8), was applied in this study to the distribution of the ages at onset of genetic diseases. The literature was reviewed for reports of genetic diseases having frequency distributions of ages at onset. Fourteen diseases with well-specified genetic etiology as well as nine other diseases where the contribution of the genetic component to the etiology is not well defined were studied. A graphic method as well as a goodness of fit test were applied to the different age at onset distributions to assess their conformity to the lognormal model. For most of the genetic diseases that have an underlying biochemical abnormality, the age at onset distributions approximated a logarithmic normal model. In seven series of cases of diseases with an established pattern of inheritance but with no defined biochemical abnormalities, only two showed a good fit to the lognormal model. For diseases with ill-defined genetic etiology or strong environmental influences, these distributions of the age at onset did not fit the lognormal model. In a multifactorial model for disease etiology, the present method may be used as a crude way for differentiating the relative importance of etiologic factors acting before and after birth.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Armenian HK,Khoury MJdoi
10.1093/oxfordjournals.aje.a113137subject
Has Abstractpub_date
1981-05-01 00:00:00pages
596-605issue
5eissn
0002-9262issn
1476-6256journal_volume
113pub_type
杂志文章abstract::The authors investigated the role of self-reported life satisfaction in mortality with a prospective cohort study (1976-1995). A nationwide sample of healthy adults (18-64 years, n = 22,461) from the Finnish Twin Cohort responded to a questionnaire about life satisfaction and known predictors of mortality in 1975. A s...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/152.10.983
更新日期:2000-11-15 00:00:00
abstract::The return of fertility for women who discontinue oral contraceptives takes longer as compared with women who discontinue other methods of contraception. It remains unclear, however, whether subsequent fertility differs according to duration or age at first use. The authors performed a nested case-control study within...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009261
更新日期:1997-08-01 00:00:00
abstract::Most, but not all, studies in Western countries have indicated that women have a higher mortality than men after an acute myocardial infarction, but this has not been well documented in the developing world. The authors studied 601 male and 294 female myocardial infarction patients, aged 26-94 years, admitted to a cit...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117059
更新日期:1994-04-01 00:00:00
abstract::The authors investigated the association between age at menarche and risk of type 2 diabetes mellitus (T2DM) among 101,415 women from the Nurses' Health Study (NHS) aged 34-59 years (1980-2006) and 100,547 women from Nurses' Health Study II (NHS II) aged 26-46 years (1991-2005). During 2,430,274 and 1,373,875 person-y...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp372
更新日期:2010-02-01 00:00:00
abstract::The effects of estrogen replacement therapy on prognosis in women with established coronary disease remain uncertain. The authors conducted a retrospective cohort study of 726 women (mean age, 66.2 years) who survived first myocardial infarction to hospital discharge from 1980 through 1991, while enrolled at Group Hea...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009100
更新日期:1997-02-01 00:00:00
abstract::The objective of this study was to examine how the consistency of self-reported exposure to dust or gas, asbestos, and quartz varied between subjects with and those without respiratory symptoms and asthma in a Norwegian community sample () in 1987-1988. Exposure characterization obtained in a structured work history i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.5.477
更新日期:2001-09-01 00:00:00
abstract::The association between dietary fat and fertility is not well studied. We evaluated intakes of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, trans fatty acids (TFA), ω-3 fatty acids, and ω-6 fatty acids in relation to fecundability in Danish and North American preconceptio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx204
更新日期:2018-01-01 00:00:00
abstract::The effect on childhood cancer of prolonged exposure to 60-H magnetic fields from electric appliances was examined using interview data from a recently completed case-control study. Exposures of children aged 0-14 years whose incident cancers were diagnosed between 1976 and 1983 and who resided in the Denver, Colorado...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115566
更新日期:1990-05-01 00:00:00
abstract::Human brucellosis in Florida is documented for the 47-year period 1928-1975. Of the 936 cases reported in 1930-1975, more than half (505) occurred in the decade 1940-1949. The incidence declined rapidly to an average rate of five cases per year, although there was an increase in 1974 and 1975. The analysis is mainly c...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112380
更新日期:1977-03-01 00:00:00
abstract::After diagnosis with prostate cancer, Black men in the United States have poorer survival than White men, even after controlling for differences in cancer stage. The extent to which these racial survival differences are due to biologic versus non-biologic factors is unclear, and it has been hypothesized that differenc...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a010221
更新日期:2000-02-15 00:00:00
abstract::Vänskä et al. (Am J Epidemiol. XXXX;XXX(XX):XXXX-XXXX)) provide us with cohort lifetime risks of cervical cancer attributable to different human papillomavirus (HPV) types in Sweden. We argue that a standardized lifetime risk such as those calculated by Vänskä et al. might be a more appropriate public health target fo...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa120
更新日期:2020-07-08 00:00:00
abstract::To facilitate an increase in the amount of data on minority subjects collected for genetic databases, the authors attempted to clarify barriers to African-American participation in genetic studies. They randomly sampled 78,072 subjects from the community (Missouri Family Registry, 2002-2007). Of these, 28,658 particip...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr084
更新日期:2011-08-01 00:00:00
abstract::The potential role of psychological stress in pancreatic cancer has rarely been investigated in epidemiologic studies. During 1991-2009, we conducted a nested case-control study based on Swedish national population and health registers to investigate whether severe psychological stress induced by the death of a child ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt045
更新日期:2013-08-15 00:00:00
abstract::The diagnostic and epidemiologic significance of antibody to hepatitis B core antigen (anti-HBc) detected by complement fixation was studied in a sample of 412 healthy persons, 0-70 years old of both sexes living in the Athens area. The prevalence of hepatitis B virus (HBV) infections was found to be very high (26.5%)...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112498
更新日期:1977-12-01 00:00:00
abstract::Prospective evidence of the associations of smoking cessation with chronic obstructive pulmonary disease (COPD) and other causes of death in Asia is scarce. Previous studies, which were mostly based on baseline smoking behavior only, were subject to sick-quitter bias and misclassification resulting from changes in smo...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwu011
更新日期:2014-05-01 00:00:00
abstract::The authors abstracted a sample of 7,536 hospital medical records to validate the accuracy of the coding of obstetric information on 1) birth certificates, 2) a statewide computerized hospital discharge abstract data system, and 3) a linked file merging birth certificates and the hospital abstract data for Washington ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116834
更新日期:1993-07-15 00:00:00
abstract::An analysis of the familial aggregation of blood pressure (BP) was conducted to provide estimates of the role of genes and household environment in determining the phenotypic resemblance between biologically related family members. The biological model used for this analysis parameterizes the correlations between fami...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112830
更新日期:1979-10-01 00:00:00
abstract::Hypertensive complications of pregnancy contribute to the burden of maternal morbidity and subsequently have an impact on neonatal morbidity and mortality. Although codes from the International Classification of Diseases should delineate the specific subtypes of pregnancy-related hypertension, how diagnoses are applie...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwm141
更新日期:2007-07-15 00:00:00
abstract::Some reports indicate that exposure to specific polychlorinated biphenyl (PCB) congeners is related to breast cancer risk. The authors recruited participants in a case-control study from October 1994 to March 1997 to assess the relation between breast cancer risk and concentrations of 14 PCB congeners measured in plas...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.7.629
更新日期:2002-04-01 00:00:00
abstract::The World Health Organization (Geneva, Switzerland) and the National Heart, Lung, and Blood Institute (Bethesda, Maryland) have developed standard categories of body mass index (BMI) (calculated as weight (kg)/height (m)(2)) of less than 18.5 (underweight), 18.5-24.9 (normal weight), 25.0-29.9 (overweight), and 30.0 o...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1093/aje/kwu111
更新日期:2014-08-01 00:00:00
abstract::The authors conducted a matched case-control study to investigate the effects of caffeine intake during pregnancy on birth weight. From January to November 1992, in the first 24 hours after delivery, 1,205 mothers (401 cases and 804 controls) were interviewed and their newborns were examined to assess birth weight and...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a009502
更新日期:1998-04-01 00:00:00
abstract::Immigration from high prevalence areas may contribute to an increased risk of tuberculosis in Europe. This study aimed at quantifying transmission of tuberculosis between and within nationalities among residents of the Netherlands. DNA "fingerprints," on the basis of restriction fragment length polymorphism using mark...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a009433
更新日期:1998-01-15 00:00:00
abstract::Hormone replacement therapy (HRT) may reduce lung cancer risk. Dietary boron may have actions similar to those of HRT; however, no previous study has reported the associations between dietary boron intake and lung cancer risk or the joint effects of boron intake and HRT use on lung cancer risk. The authors examined th...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn021
更新日期:2008-05-01 00:00:00
abstract::Cigarette smoking is becoming increasingly common in Asia while quitting remains rare, in part because of a lack of knowledge about the risks of smoking. This study compared the risk of death from lung cancer associated with smoking habits in Australia and New Zealand and in Asia by using data from the Asia Pacific Co...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwm002
更新日期:2007-06-01 00:00:00
abstract::The mortality experience of 8679 members of a metal trades union--men employed in shipyards, metal fabrication shops, small boat yards, and field construction--was studied from 1950 to 1976 by the historical prospective method. Relative to rates for US men of comparable age and race, the risk of death from all causes ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::The relationship of social status and behavior type to the incidence of coronary heart disease was examined among husbands and wives in the Framingham Heart Study. Between 1965 and 1967, 269 spouse pairs, in which the husbands were 45-64 years of age, were administered an extensive psychosocial questionnaire. These pa...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113611
更新日期:1983-07-01 00:00:00
abstract::To compare growth patterns of obesity indices derived from body composition and anthropometric measures, the authors analyzed data from Project HeartBeat!, a longitudinal study of cardiovascular disease risk factors in childhood and adolescence. A total of 678 children initially aged 8, 11, and 14 years in The Woodlan...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf109
更新日期:2002-10-15 00:00:00
abstract::In the summer of 1991, four inmates from prison A in Upstate New York died of multi-drug-resistant tuberculosis. To determine the extent of resistant tuberculosis at prison A and transmission patterns, the authors interviewed staff and reviewed medical records and inmate movement histories. Contact investigation resul...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117222
更新日期:1994-07-15 00:00:00
abstract::A recent study of two communities in Massachusetts showed that a group of high school sophomores exposed to 107 mg/liter sodium in their municipal drinking water had significantly higher systolic and diastolic blood pressures than a control group exposed to 8 mg/liter. The present study was undertaken to determine if ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113252
更新日期:1981-12-01 00:00:00
abstract::Although psychotropic drug use has been associated with increased risk of falls in long-term care settings; this association may be confounded by the high prevalence of dementia and depression and other fall risk factors. This question was addressed in a prospective cohort study of recurrent falls among 282 ambulatory...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117619
更新日期:1995-07-15 00:00:00