Abstract：
:A single nucleotide polymorphism, - 160C-->A, has been identified in the promoter region of the E-cadherin gene and has been shown to alter its transcriptional activity. To assess susceptibility of -160A allele carriers to seven types of cancers, the authors conducted a comprehensive meta-analysis, up to November 2006, of 26 case-control studies comprising 7,042 cases and 7,011 controls. Pooled odds ratios and 95% confidence intervals were calculated by using the random-effects model. Publication bias, subgroup, and sensitivity analyses were also performed, which showed that -160A allele carriers, compared with noncarriers, had about a 17-19% increased risk of several invasive/metastatic tumors. Analyses of various types of cancers revealed that, in Europeans, the -160AA homozygote was associated with an increased risk of urothelial cancer, carriers of -160A were at increased risk of lung and prostate cancers, and carriers of -160A with gastric cancer were found to suffer a significantly increased risk, whereas their Asian counterparts seemed to be tolerant. No evidence was found that the -160A allele predisposed its carriers to breast, colorectal, or esophageal cancers. These findings indicate that -160A of the E-cadherin gene is emerging as a low-penetrance tumor susceptibility allele for the development of gastric, lung, prostate, and urothelial cancers.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Wang GY,Lu CQ,Zhang RM,Hu XH,Luo ZWdoi
10.1093/aje/kwm264subject
Has Abstractpub_date
2008-01-01 00:00:00pages
7-14issue
1eissn
0002-9262issn
1476-6256pii
kwm264journal_volume
167pub_type
杂志文章,meta分析,评审abstract：:The possible relation between the occurrence of brain tumors in children and exposure to electric blankets or electrically heated water beds was investigated in a multicenter, population-based case-control study conducted on the West Coast of the United States. Information on maternal exposure during pregnancy or dire...
journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/oxfordjournals.aje.a008688
更新日期：1996-06-01 00:00:00
abstract：:Human brucellosis in Florida is documented for the 47-year period 1928-1975. Of the 936 cases reported in 1930-1975, more than half (505) occurred in the decade 1940-1949. The incidence declined rapidly to an average rate of five cases per year, although there was an increase in 1974 and 1975. The analysis is mainly c...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112380
更新日期：1977-03-01 00:00:00
abstract：:Much of epidemiology and clinical medicine is focused on estimating the effects of treatments or interventions administered over time. In such settings of longitudinal treatment, time-dependent confounding is often an important source of bias. Marginal structural models (MSMs) are a powerful tool for estimating the ca...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm232
更新日期：2007-11-01 00:00:00
abstract：:This study prospectively evaluated psychosocial as well as biologic, behavioral, and demographic factors in the development of duodenal ulcer. Baseline data were collected in 1963 on 8,458 Israeli men over age 40 years who had no history of duodenal ulcer. The subjects were followed for 5 years, and 254 reported the d...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116436
更新日期：1992-11-15 00:00:00
abstract：:This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free dermatologic controls who had had noncancerous skin disorders diagnosed bet...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a117297
更新日期：1994-10-01 00:00:00
abstract：:Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to curr...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009997
更新日期：1999-08-01 00:00:00
abstract：:How can the "strengths" of risk factors, in the sense of how well they discriminate cases from controls, be compared when they are measured on different scales such as continuous, binary, and integer? Given that risk estimates take into account other fitted and design-related factors-and that is how risk gradients are...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwv193
更新日期：2015-11-15 00:00:00
abstract：:Rhinovirus infections in Seattle families with schoolchildren (1975-1979) and in selected outpatients were revealed by virus shedding or antibody rise. These observations extend those in the Seattle Virus Watch (1965-1969). Analysis of rhinovirus serotype prevalence again revealed certain "common" persisting serotypes...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114166
更新日期：1985-11-01 00:00:00
abstract：:Sequences of treatments that adapt to a patient's changing condition over time are often needed for the management of chronic diseases. An adaptive treatment strategy (ATS) consists of personalized treatment rules to be applied through the course of a disease that input the patient's characteristics at the time of dec...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwz272
更新日期：2020-05-05 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwk011
更新日期：2007-02-01 00:00:00
abstract：:The authors describe an approach to the analysis of case-control studies in which the exposure variables are continuous, i.e., quantitative variables, and one wishes neither to categorize levels of the exposure variable nor to assume a log-linear relation between level of exposure and disease risk. A dose-response ass...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008970
更新日期：1996-09-15 00:00:00
abstract：:Geographic information systems and exploratory spatial analysis were used to describe the geographic characteristics of pilot fatality rates in 1983-1998 general aviation crashes within the continental United States. The authors plotted crash sites on a digital map; rates were computed at regular grid intersections an...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/155.5.398
更新日期：2002-03-01 00:00:00
abstract：:Mendelian randomization (MR) is a method for estimating the causal relationship between an exposure and an outcome using a genetic factor as an instrumental variable (IV) for the exposure. In the traditional MR setting, data on the IV, exposure, and outcome are available for all participants. However, obtaining comple...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwt084
更新日期：2013-10-01 00:00:00
abstract：:Investigations of gene (G)-environment (E) interactions have led to limited findings to date, possibly due to weak effects of individual genetic variants. Polygenic risk scores (PRS), which capture the genetic susceptibility associated with a set of variants, can be a powerful tool for detecting global patterns of int...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwz175
更新日期：2019-11-01 00:00:00
abstract：:The US Great Recession resulted in an alarming number of home foreclosures that weakened the social and physical environment of thousands of neighborhoods. Few studies have evaluated whether these neighborhood changes were related to changes in individual behaviors. We examined the relationship between changes in neig...
journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/aje/kwy075
更新日期：2018-09-01 00:00:00
abstract：:To quantify nonresponse bias and estimate its potential impact, the authors compared census-based socioeconomic and demographic factors and geographic locations among respondents and nonrespondents in a multicenter case-control study of non-Hodgkin lymphoma (1998-2000). Using a geographic information system, the autho...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm292
更新日期：2008-02-01 00:00:00
abstract：:The relation between self-reported physical activity and depressive symptoms was analyzed for 1,900 healthy subjects aged 25-77 years in the Epidemiologic Follow-up Study (1982-1984) to the first National Health and Nutrition Examination Survey (NHANES I). Depressive symptomatology as measured by the Center for Epidem...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115087
更新日期：1988-12-01 00:00:00
abstract：:This study used cross-sectional data for 19,704 white men and 13,895 white women from the Chicago Heart Association Detection Project in Industry (November 1967 to January 1973) to investigate whether weight explains the association between age and blood pressure, and in particular, whether age is associated with bloo...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114434
更新日期：1986-10-01 00:00:00
abstract：:Although effective in controlling malaria, indoor residual spraying results in elevated exposure to insecticides such as dichlorodiphenyltrichloroethane (DDT) and pyrethroids. These chemicals cross the placenta, but no studies have examined their associations with birth outcomes in populations residing in indoor resid...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwy143
更新日期：2019-01-01 00:00:00
abstract：:Dietary protein may help prevent age-related declines in strength and functional capacity. This study examines the independent relationship between dietary protein and longitudinal changes in physical functioning among adults participating in the Framingham Offspring Study from examination 5 (1991-1995) to examination...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwy014
更新日期：2018-07-01 00:00:00
abstract：:Assessing vitamin and mineral supplement use is important because supplement use per se is an exposure of interest for the risk of several chronic diseases and because supplements contribute a large proportion of total (diet plus supplement) micronutrient intake, another important exposure in epidemiologic research. U...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/148.7.643
更新日期：1998-10-01 00:00:00
abstract：:In a prospective study carried out in June 1979-April 1981, 134 of 1,458 adult inpatients at New England Deaconess Hospital, Boston, Massachusetts, acquired 136 urinary tract infections during 1,474 indwelling bladder catheterizations. Multiple logistic regression analysis identified nine factors that were significant...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114487
更新日期：1986-12-01 00:00:00
abstract：:Despite interest in the built food environment, little is known about the validity of commonly used secondary data. The authors conducted a comprehensive field census identifying the locations of all food outlets using a handheld global positioning system in 8 counties in South Carolina (2008-2009). Secondary data wer...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwq292
更新日期：2010-12-01 00:00:00
abstract：:The impact of summertime haze episodes on daily variations in symptoms and peak expiratory flow rates (PEFRs) was examined in a study of 108 children living in State College, Pennsylvania, during the summer of 1991. Twice daily, each child recorded symptoms, PEFRs and hours spent outdoors. Environmental measurements i...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008818
更新日期：1996-04-15 00:00:00
abstract：:Vaccinating school-aged children against influenza can reduce age-specific and population-level illness attack rates. Using a stochastic simulation model of influenza transmission, the authors assessed strategies for vaccinating children in the United States, varying the vaccine type, coverage level, and reproductive ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp237
更新日期：2009-09-15 00:00:00
abstract：:The authors examined the relative importance of dietary sodium, potassium, calcium, and magnesium intakes as correlates of blood pressure in a cross-sectional analysis of 987 black and 1,043 white 9- and 10-year-old girls from Richmond, California, Cincinnati, Ohio, and Washington, DC, who were enrolled in the Nationa...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116975
更新日期：1994-01-15 00:00:00
abstract：:The authors examined the associations of observed neighborhood (block face) and housing conditions with the incidence of diabetes by using data from 644 subjects in the African-American Health Study (St. Louis area, Missouri). They also investigated five mediating pathways (health behavior, psychosocial, health status...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm190
更新日期：2007-08-15 00:00:00
abstract：:After diagnosis with prostate cancer, Black men in the United States have poorer survival than White men, even after controlling for differences in cancer stage. The extent to which these racial survival differences are due to biologic versus non-biologic factors is unclear, and it has been hypothesized that differenc...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010221
更新日期：2000-02-15 00:00:00
abstract：:An exact probability test and its asymptotic version are described for testing the hypothesis that clustering of disease observed among population units is likely to have been due to chance alone. The test is based on a scheme for ranking possible arrangements of ill and well persons by degree of clustering, as measur...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113684
更新日期：1983-11-01 00:00:00
abstract：:In this issue of the Journal, Van Ewijk et al. (Am J Epidemiol. 2013;177(8):729-736) report intriguing associations between prenatal exposure to the religious month of Ramadan and body anthropometry among adult Muslims in Indonesia. They categorized prenatal exposure according to the relative timing of Ramadan and the...
journal_title：American journal of epidemiology
pub_type： 评论,杂志文章
doi：10.1093/aje/kwt024
更新日期：2013-04-15 00:00:00
