当前位置： SCI文献检索 > AMERICAN JOURNAL OF EPIDEMIOLOGY期刊下所有文献 > Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project.

Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project.

Abstract：

:The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.

journal_name

Am J Epidemiol

journal_title

American journal of epidemiology

authors

Benet M,Albang R,Pinart M,Hohmann C,Tischer CG,Annesi-Maesano I,Baïz N,Bindslev-Jensen C,Lødrup Carlsen KC,Carlsen KH,Cirugeda L,Eller E,Fantini MP,Gehring U,Gerhard B,Gori D,Hallner E,Kull I,Lenzi J,McEachan R,Mi

doi

10.1093/aje/kwy242

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

408-417

issue

eissn

0002-9262

issn

1476-6256

pii

5142391

journal_volume

188

pub_type

杂志文章

在线工具

Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project.