Abstract:
:Adult height is determined by genetics and childhood nutrition, but childhood infections may also play a role. Monozygotic twins are genetically matched and offer an advantage when identifying environmental determinants. In 2005-2007, we examined the association of childhood infections with adult height in 140 height-discordant monozygotic twin pairs from the California Twin Program. To obtain information on childhood infections and growth, we interviewed the mothers of monozygotic twins who differed in self-reported adult height by at least 1-inch (2.5 cm). Within-pair differences in the relative frequency of childhood infections were highly correlated, especially within age groups. A conditional logistic regression analysis demonstrated that more reported episodes of febrile illness occurred in the twin with shorter stature (odds ratio = 2.00, 95% confidence interval: 1.18, 3.40). The association was strongest for differences in the relative frequency of infection during the toddler years (ages 1-5: odds ratio = 3.34, 95% confidence interval: 1.47, 7.59) and was similar when restricted to twin pairs of equal birth length. The association was not explained by differential nutritional status. Measures of childhood infection were associated with height difference in monozygotic twin pairs, independent of genome, birth length, and available measures of diet.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Hwang AE,Mack TM,Hamilton AS,Gauderman WJ,Bernstein L,Cockburn MG,Zadnick J,Rand KA,Hopper JL,Cozen Wdoi
10.1093/aje/kwt012subject
Has Abstractpub_date
2013-08-15 00:00:00pages
551-8issue
4eissn
0002-9262issn
1476-6256pii
kwt012journal_volume
178pub_type
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