Abstract:
:The utility of a risk function in clinical practice is an important concept that has received insufficient attention. The authors evaluated the clinical usefulness of the Framingham risk function (FRF) for cardiovascular disease in a Middle Eastern population (2,640 men and 3,584 women aged 30-74 years) free of cardiovascular disease at baseline in 1999. They calculated the net benefit fraction for treatment of subjects with an estimated 10-year risk of ≥10% and also ≥20%, where the net benefit fraction is a weighted sum of true-positive and false-positive rates divided by incidence, as estimated by Kaplan-Meier analysis. The authors drew a decision curve by plotting the net benefit fraction against a wide range of risk thresholds for treatment. The cumulative incidence of cardiovascular disease was 7.6% and 12.3% in women and men, respectively. The FRF had a C index of 0.832 in women and 0.785 in men with a reasonable calibration. On the basis of the net benefit fraction, about 50% of the incidence in men and women could be appropriately treated by using the 10% threshold; however, the FRF was not useful at the 20% threshold, especially in women. In both genders, usefulness of the FRF was as good as the function derived directly from Tehrani data with the same variables; however, it could be useful in low thresholds for treatment.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Khalili D,Hadaegh F,Soori H,Steyerberg EW,Bozorgmanesh M,Azizi Fdoi
10.1093/aje/kws204subject
Has Abstractpub_date
2012-08-01 00:00:00pages
177-86issue
3eissn
0002-9262issn
1476-6256pii
kws204journal_volume
176pub_type
杂志文章abstract::Variants of inflammatory and immune response genes have been associated with adverse respiratory outcomes following exposure to air pollution. However, the genes involved and their associations are not well characterized, and there has been no systematic review. Thus, we conducted a review following the guidelines of ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/aje/kwt269
更新日期:2014-02-15 00:00:00
abstract::Individual-level health behaviors and outcomes have multi-level determinants (individual and environmental). Multi-level analysis seeks to explain individual outcomes in terms of both individual and environmental or aggregate variables. Ecologic fallacy (improper inference about individual-level associations based on ...
journal_title:American journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.aje.a116207
更新日期:1992-05-15 00:00:00
abstract::Unbiased estimation of causal parameters from marginal structural models (MSMs) requires a fundamental assumption of no unmeasured confounding. Unfortunately, the time-varying covariates used to obtain inverse probability weights are often error-prone. Although substantial measurement error in important confounders is...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww068
更新日期:2016-08-01 00:00:00
abstract::The natural history of infection with human immunodeficiency virus type 1 (HIV-1) is characterized by a relentless decline in CD4-positive lymphocytes and the ultimate development of acquired immunodeficiency syndrome (AIDS). However, variables other than the CD4-positive lymphocyte level contribute to the measurement...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1093/oxfordjournals.aje.a116215
更新日期:1992-05-15 00:00:00
abstract::A battalion of United States Marines traveling to South Korea in the spring of 1976 was studied to determine the incidence and etiology of gastroenteritis. During the three weeks they visited South Korea, 21% of 694 marines developed diarrhea. Stool and serum specimens collected before, during, and after their stay we...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract::The association of serum selenium with the subsequent risk of death from cancer was investigated in a case-control study that was nested in a prospective nine-year follow-up study in the Netherlands. In 1975-1978, 10,532 persons in the Dutch town of Zoetermeer who were aged five years or more participated in a medical...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114493
更新日期:1987-01-01 00:00:00
abstract::Epidemiologic research that uses administrative records (rather than registries or clinical surveys) to identify cases for study has been increasingly restricted because of concerns about privacy, making unbiased population-based research less practicable. In their article, Nattinger et al. (Am J Epidemiol. 2010;172(6...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwq219
更新日期:2010-09-15 00:00:00
abstract::Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp238
更新日期:2009-10-15 00:00:00
abstract::Whether genetic and familial factors influence the association between cardiorespiratory fitness (CRF) and cardiovascular disease (CVD) is unknown. Two cohorts were formed based on data from 1,212,295 men aged 18 years who were conscripted for military service in Sweden during 1972-1996. The first comprised 4,260 twin...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwaa060
更新日期:2020-10-01 00:00:00
abstract::The author evaluated the validity of four historically based variables collected on Georgia birth certificates: outcome of preceding pregnancy, history of delivery of a low- (<2,500 g) or high- (>4,000 g) birth-weight infant, and death of the baby resulting from the preceding pregnancy. Data were derived from birth an...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.10.883
更新日期:2001-11-15 00:00:00
abstract::The authors examined the prevalence of congenital malformations among births in Benton and Franklin counties, in southeastern Washington State, from 1968 through 1980. The Hanford Site is in this area and serves as a major employer. In addition, various agriculturally and chemically related activities are in the area....
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114800
更新日期:1988-02-01 00:00:00
abstract::Evidence for a relation between physical activity and renal cell cancer has been inconsistent. The authors examined physical activity in relation to renal cell cancer in a large, prospective US cohort study of 482,386 participants (289,503 men and 192,883 women) aged 50-71 years at baseline (1995-1996). At baseline, p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn102
更新日期:2008-07-15 00:00:00
abstract::Physical functioning measures are considered integrated markers of the aging process. This prospective investigation examined relations between dietary intake of women at midlife in 1996-1997 and prevalence of physical functioning limitations 4 years later, defined by the Medical Outcomes Study Short-Form 36. The samp...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm397
更新日期:2008-04-15 00:00:00
abstract::In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) was initiated in 2002. AGES-Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relati...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwk115
更新日期:2007-05-01 00:00:00
abstract::Recent studies of patients with coronary heart disease (CHD) at baseline have shown that their cholesterol levels are much less predictive of subsequent mortality than in populations free of CHD (FCHD). One previously suggested explanation of this attenuation is that the impact of hyperlipidemia on atherosclerosis or ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112852
更新日期:1979-12-01 00:00:00
abstract::Simulation studies using susceptible-infectious-recovered models were conducted to estimate individuals' risk of infection and time to infection in small-world and randomly mixing networks. Infection transmitted more rapidly but ultimately resulted in fewer infected individuals in the small-world, compared with the ra...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi308
更新日期:2005-11-15 00:00:00
abstract::The authors investigated the association between intrauterine growth and intellectual disability (ID). The appropriateness of intrauterine growth was assessed using percentage of optimal birth weight, a measure that accounts for gestational age, maternal height, parity, and infant sex. Using population-based record li...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm245
更新日期:2008-01-01 00:00:00
abstract::As part of a prospective study of cardiovascular disease (CVD) in middle-aged Chinese men in Taiwan, 1820 Chinese males, aged 40--59 years, from the middle and upper socioeconomic classes, were characterized at study entry by a history and physical examination with particular reference to cardiovascular status and by ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112861
更新日期:1980-01-01 00:00:00
abstract::In the absence of prior knowledge about population relations, investigators frequently employ a strategy that uses the data to help them decide whether to adjust for a variable. The authors compared the performance of several such strategies for fitting multiplicative Poisson regression models to cohort data: 1) the "...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116813
更新日期:1993-12-01 00:00:00
abstract::The relation of oral contraceptive (OC) use to the risk of hospitalization for myocardial infarction (MI) was evaluated among 121,964 US nurses who responded to a mail questionnaire. There were 156 women who reported having been hospitalized for MI before the menopause, and 23 (15%) were OC users at the time of the MI...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112874
更新日期:1980-01-01 00:00:00
abstract::A recent trial showed that universal decolonization in adult intensive care units (ICUs) resulted in greater reductions in all bloodstream infections and clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) than either targeted decolonization or screening and isolation. Since regional health-care fa...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww008
更新日期:2016-03-01 00:00:00
abstract::The authors previously reported statistically significant inverse associations between adult onset glioma and histories of chickenpox and shingles among 462 cases and 443 controls in the San Francisco Bay Area Adult Glioma Study (1991--1995) and a suggestive but nonsignificant inverse association with immunoglobulin G...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.2.161
更新日期:2001-07-15 00:00:00
abstract::From March to July of 2011, the authors investigated the prospective association between illicit drug use and cognitive functioning during the midadult years. A total of 8,992 participants who were surveyed at 42 years of age in the National Child Development Study (1999-2000) were included. The authors analyzed data ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr315
更新日期:2012-02-01 00:00:00
abstract::Prospective epidemiologic data on the association between vitamin D and mortality are limited, particularly in Asian populations. Among subjects in Linxian, China, the authors aimed to test whether baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations in a prospective cohort were associated with all-cause mortal...
journal_title:American journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/aje/kws285
更新日期:2012-12-01 00:00:00
abstract::Although poorer self-rated health (SRH) is associated with increased mortality, less is known about its impact on functioning. This study evaluated whether poorer SRH was associated with decline in walking speed and whether caregiving, often considered an indicator of chronic stress, modified this relation. The sample...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq445
更新日期:2011-04-15 00:00:00
abstract::In the spring of 1986, the authors studied the relation between body mass index and anthropometric indicators of fat distribution to cardiovascular risk factors (serum lipids and blood pressure) in approximately 450 women aged 38 years randomly selected from population registers in five European centers. Waist circumf...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115322
更新日期:1989-07-01 00:00:00
abstract::A recent study of two communities in Massachusetts showed that a group of high school sophomores exposed to 107 mg/liter sodium in their municipal drinking water had significantly higher systolic and diastolic blood pressures than a control group exposed to 8 mg/liter. The present study was undertaken to determine if ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113252
更新日期:1981-12-01 00:00:00
abstract::A standardized method for examining hearts and coronary arteries was applied in a study of sudden deaths in 227 autopsies of New Orleans men aged 25-49 years. Of these autopsies, 102 deaths were due to external violence, 125 were from natural causes and 45 occurred suddenly. Of the sudden natural deaths, 14 (31%) were...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113036
更新日期:1980-11-01 00:00:00
abstract::The association between cervical carcinoma and vaginal douching was examined in a population-based case-control study conducted in the low-risk population of Utah between 1984 and 1987. The authors compared 266 cases of in situ and invasive cervical carcinoma with 408 group-matched controls by vaginal douching behavio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115890
更新日期:1991-02-15 00:00:00
abstract::This paper concerns the effects of random error in numerical measurements of risk factors (covariates) in relative risk regressions. When not dependent on outcome (nondifferential), such error usually attenuates relative risk estimates (shifts them toward one) and leads to spuriously narrow confidence intervals. The p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115761
更新日期:1990-12-01 00:00:00