Abstract:
:Variants of inflammatory and immune response genes have been associated with adverse respiratory outcomes following exposure to air pollution. However, the genes involved and their associations are not well characterized, and there has been no systematic review. Thus, we conducted a review following the guidelines of the Human Genome Epidemiology Network. Six observational studies and 2 intervention studies with 14,903 participants were included (2001-2010). Six studies showed at least 1 significant gene-pollutant interaction. Meta-analysis was not possible due to variations in genes, pollutants, exposure estimates, and reported outcomes. The most commonly studied genes were tumor necrosis factor α (TNFA) (n = 6) and toll-like receptor 4 (TLR4) (n = 3). TNFA -308G>A modified the action of ozone and nitrogen dioxide on lung function, asthma risk, and symptoms; however, the direction of association varied between studies. The TLR4 single-nucleotide polymorphisms rs1927911, rs10759931, and rs6478317 modified the association of particulate matter and nitrogen dioxide with asthma. The transforming growth factor β1 (TGFB1) polymorphism -509C>T also modified the association of pollutants with asthma. This review indicates that genes controlling innate immune recognition of foreign material (TLR4) and the subsequent inflammatory response (TGFB1, TLR4) modify the associations of exposure to air pollution with respiratory function. The associations observed have biological plausibility; however, larger studies with improved reporting are needed to confirm these findings.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Vawda S,Mansour R,Takeda A,Funnell P,Kerry S,Mudway I,Jamaludin J,Shaheen S,Griffiths C,Walton Rdoi
10.1093/aje/kwt269subject
Has Abstractpub_date
2014-02-15 00:00:00pages
432-42issue
4eissn
0002-9262issn
1476-6256pii
kwt269journal_volume
179pub_type
杂志文章,评审abstract::Increasing evidence suggests that maternal stress during pregnancy may influence pregnancy outcomes. In a nationwide Swedish study including almost 3 million births taking place during 1973-2006, we investigated whether maternal bereavement during pregnancy is associated with stillbirth risk. Through individual record...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kws383
更新日期:2013-02-01 00:00:00
abstract::Rhinovirus infections in Seattle families with schoolchildren (1975-1979) and in selected outpatients were revealed by virus shedding or antibody rise. These observations extend those in the Seattle Virus Watch (1965-1969). Analysis of rhinovirus serotype prevalence again revealed certain "common" persisting serotypes...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114166
更新日期:1985-11-01 00:00:00
abstract::Several design options available in the planning stage of case-control studies are examined. Topics covered include matching, control/case ratio, choice of nested case-control or case-cohort design, two-stage sampling, and other methods that can be used for control selection. The effect of potential problems in obtain...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116398
更新日期:1992-05-01 00:00:00
abstract::The relation between plasma insulin level and the prevalence of coronary heart disease was studied in a representative nondiabetic population sample of 396 men and 673 women aged 65-74 years in Kuopio, eastern Finland, in 1986-1988. No association between plasma insulin levels and the prevalence of previous myocardial...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116621
更新日期:1993-06-01 00:00:00
abstract::The objective of this study was to examine how the consistency of self-reported exposure to dust or gas, asbestos, and quartz varied between subjects with and those without respiratory symptoms and asthma in a Norwegian community sample () in 1987-1988. Exposure characterization obtained in a structured work history i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.5.477
更新日期:2001-09-01 00:00:00
abstract::Increasingly, investigators append census-based socioeconomic characteristics of residential areas to individual records to address the problem of inadequate socioeconomic information on health data sets. Little empirical attention has been given to the validity of this approach. The authors estimate health outcome eq...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009673
更新日期:1998-09-01 00:00:00
abstract::In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/155.5.478
更新日期:2002-03-01 00:00:00
abstract::The state of pneumococcal carriage-that is, pneumococcal colonization in the nasopharynx of healthy persons-represents a reservoir for the spread of pneumococci among individuals. In light of the introduction of new pneumococcal conjugate vaccines, further knowledge on the dynamics of pneumococcal carriage is importan...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp351
更新日期:2010-01-15 00:00:00
abstract::Evidence for a relation between physical activity and renal cell cancer has been inconsistent. The authors examined physical activity in relation to renal cell cancer in a large, prospective US cohort study of 482,386 participants (289,503 men and 192,883 women) aged 50-71 years at baseline (1995-1996). At baseline, p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn102
更新日期:2008-07-15 00:00:00
abstract::The 1982-1984 Hispanic Health and Nutrition Examination Survey used ultrasonography to investigate risk factors for gallstone disease (gallstones or cholecystectomy). Mexican American, Cuban American, and Puerto Rican men (n = 968) and women (n = 1,325) aged 20-74 years were selected from household samples in nine sta...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115574
更新日期:1990-05-01 00:00:00
abstract::Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation b...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117283
更新日期:1994-09-15 00:00:00
abstract::The etiology of Warthin's tumor, a benign parotid gland tumor, is unknown. Recent evidence suggests a possible relation with cigarette smoking as well as increasing incidence. We reviewed the medical record of subjects with a major salivary gland tumor newly diagnosed in Jefferson County, Alabama, from 1968 to 1989, a...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008906
更新日期:1996-07-15 00:00:00
abstract::Studies investigating antenatal caffeine consumption and reproductive outcomes show conflicting results, and most studies have used maternal self-reported caffeine consumption to estimate fetal exposure. This study (n=1,606) was specifically designed to test the association of caffeine and its primary metabolites in u...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwj125
更新日期:2006-06-01 00:00:00
abstract::To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwj328
更新日期:2006-12-15 00:00:00
abstract::Narrowing and other changes in retinal arterioles may reflect damage due to hypertension, which may predict stroke and other cardiovascular diseases independently of blood pressure level. Newly developed quantitative methods of assessing retinal narrowing are used to determine whether this sign is related only to curr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009997
更新日期:1999-08-01 00:00:00
abstract::A recent trial showed that universal decolonization in adult intensive care units (ICUs) resulted in greater reductions in all bloodstream infections and clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) than either targeted decolonization or screening and isolation. Since regional health-care fa...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww008
更新日期:2016-03-01 00:00:00
abstract::During the period from September 8 to October 2, 1970, 44 of the 120 children and 78 of 141 adults questioned at the Children's Asthma Research Institute and Hospital experienced gastroenteritis characterized by nausea, vomiting, and fever and/or chills. Diarrhea was rare in children (4.5%) and common in adults (74%)....
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112154
更新日期:1975-09-01 00:00:00
abstract::The relation of oral contraceptive (OC) use to the risk of hospitalization for myocardial infarction (MI) was evaluated among 121,964 US nurses who responded to a mail questionnaire. There were 156 women who reported having been hospitalized for MI before the menopause, and 23 (15%) were OC users at the time of the MI...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112874
更新日期:1980-01-01 00:00:00
abstract::Low birth weight of offspring has been associated with increased risk of maternal cardiovascular mortality, and cardiovascular risk factors measured within pregnancy have been related to offspring birth weight. It is not clear whether cardiovascular risk factors assessed prior to pregnancy are associated with the offs...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm272
更新日期:2007-12-15 00:00:00
abstract::The case-only design, which requires only diseased subjects, allows for estimation of multiplicative interactions between factors known to be independent in the study population. The design is being used as an alternative to the case-control design to study gene-environment interactions. Estimates of gene-environment ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.8.687
更新日期:2001-10-15 00:00:00
abstract::The prevalence of Down syndrome was studied among all live births occurring between 1989 and 1991 in the California counties monitored by the California Birth Defects Monitoring Program. Objectives of this study were: 1) to calculate adjusted prevalence rates and quinquennial maternal age-specific risk rates of Down s...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009084
更新日期:1997-01-15 00:00:00
abstract::The first naturally acquired case of cholera reported in the United States since 1911 occurred in a 51-year-old resident of Port Lavaca, Texas. Extensive epidemiologic investigation of the patient's contacts and environment did not identify a cholera carrier of elucidate a pathway of transmission, but several avenues ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112061
更新日期:1974-12-01 00:00:00
abstract::Long term recalls of dietary intake are frequently used in case-control studies, but their validity and reliability have not been established. In this study, 91 middle-aged adults (median age, 50 years) who were participants in the Longitudinal Study of Child Health and Development at the Harvard School of Public Heal...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115404
更新日期:1989-11-01 00:00:00
abstract::This longitudinal study examined the mortality and cancer experience of workers at the Gulf Oil refinery located in Port Arthur, Texas. The cohort was studied over a period of 41 years, from 1937 to 1978, and consisted of 16,880 employees, with an accumulation of 406,198 person-years; 4361 deaths were observed. Emphas...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113658
更新日期:1983-10-01 00:00:00
abstract::We examined the association between mood disorders and risk of herpes zoster in two case-control studies using data from nationwide Danish registries and practices in the UK Clinical Practice Research Datalink. We included incident zoster cases diagnosed in general practice (using systemic antivirals as a proxy in Den...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx338
更新日期:2018-05-01 00:00:00
abstract::Maternal angiogenic factors (placental growth factor, soluble fms-like tyrosine kinase 1 (Flt-1), and soluble endoglin) may be associated with fetal growth restriction, and the associations may differ according to stage of pregnancy. Among children born to pregnant women without preeclampsia in Norway between 1992 and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwq373
更新日期:2011-03-15 00:00:00
abstract::Differential survival associated with insulin-dependent diabetes mellitus (IDDM) was evaluated in a cross-country study using four population-based IDDM cohorts from Japan (n = 1,374), Israel (n = 610), Allegheny County, Pennsylvania (n = 995), and Finland (n = 5,144). For the purpose of this cross-country comparison,...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1995-09-15 00:00:00
abstract::The receiver operating characteristic curve is a commonly used tool for evaluating biomarker usefulness in clinical diagnosis of disease. Frequently, biomarkers being assessed have immeasurable or unreportable samples below some limit of detection. Ignoring observations below the limit of detection leads to negatively...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwk011
更新日期:2007-02-01 00:00:00
abstract::Although the inverse association between hysterectomy and epithelial ovarian cancer (EOC) was considered well established, investigators in recent studies including women diagnosed after 2000 have observed modest increases in risk. Most studies have been conducted in white women with little representation of African-A...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx055
更新日期:2017-07-01 00:00:00
abstract::In 2018, the Society for Epidemiologic Research and its partner journal, the American Journal of Epidemiology, assembled a working group to develop a set of papers devoted to the "future of epidemiology." These 14 papers covered a wide range of topic areas and perspectives, from thoughts on our profession, teaching, a...
journal_title:American journal of epidemiology
pub_type: 社论
doi:10.1093/aje/kwz045
更新日期:2019-05-01 00:00:00