Abstract:
:Dosemeci et al. (Am J Epidemiol 1990; 132:746-8) gave examples in which nondifferential misclassification of exposure reversed the direction of a trend. Gilbert (Am J Epidemiol 1991; 134:440-1) proposed that these examples occurred because the errors in exposure were systematic, and she pointed out that the relation between the measured and the true exposure was not monotonic. Assuming that the mean response either monotonically increases or decreases with the true exposure and that the exposure misclassification is nondifferential, the authors show that if the mean value of the measured exposure increases with the true exposure, then the direction of the trend cannot be reversed. Consequently, Gilbert's intimation that reversal of trend can only occur when errors are systematic is correct. However, the present authors' result is stronger in that even when errors in assessing exposure do include a systematic component, if monotonicity can be assumed, reversal of trend cannot occur. The weaker condition of positive correlation between the measured and true exposure is not sufficient to guarantee nonreversal of trend, as they show by example.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Weinberg CR,Umbach DM,Greenland Sdoi
10.1093/oxfordjournals.aje.a117283subject
Has Abstractpub_date
1994-09-15 00:00:00pages
565-71issue
6eissn
0002-9262issn
1476-6256journal_volume
140pub_type
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