Abstract:
:The authors examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes among 675,496 Korean men from the database of the National Health Insurance Corporation. During an average follow-up of 7.5 years (1996-2005), 52,995 men developed type 2 diabetes. Men with overweight, obese I, and obese II classifications had 1.47, 2.05, and 3.69 times higher risk of type 2 diabetes, respectively, compared with normal weight men, and men with low, medium, and high activity had 5%, 10%, and 9% lower risk of type 2 diabetes, respectively, compared with inactive men after adjustment for confounders and physical activity or body mass index for each other. Overweight and obesity were detrimental within all activity categories, and meeting the activity recommendations (medium and high activity) was beneficial at all body mass index levels. Meeting the activity recommendations appeared to attenuate some negative effects of overweight or obesity, and the increased risk of type 2 diabetes due to inactivity was lower in normal weight men. Both preventing overweight or obesity and increasing physical activity are important to reduce the global epidemic of type 2 diabetes, regardless of body weight and activity levels.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Lee DC,Park I,Jun TW,Nam BH,Cho SI,Blair SN,Kim YSdoi
10.1093/aje/kwr471subject
Has Abstractpub_date
2012-07-01 00:00:00pages
43-51issue
1eissn
0002-9262issn
1476-6256pii
kwr471journal_volume
176pub_type
杂志文章abstract::Cancer is an important cause of morbidity in the elderly, and many medical conditions and treatments influence cancer risk. The Surveillance, Epidemiology, and End Results (SEER)-Medicare database can be used to conduct population-based case-control studies that elucidate the etiology of cancer among the US elderly. S...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr146
更新日期:2011-10-01 00:00:00
abstract::Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-20...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr373
更新日期:2012-04-01 00:00:00
abstract::Between 1977 and 1981, there were 4.9 episodes of community-acquired bacteremia and 5.1 episodes of hospital-acquired bacteremia per 1,000 patients in the four major hospitals of one metropolitan area. Case fatality rates were 30.1 per cent based on deaths due to all causes and 14.7 per cent based on deaths attributed...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114205
更新日期:1986-01-01 00:00:00
abstract::Physical activity tends to decline from childhood into adulthood. Maintaining high levels of physical activity throughout life is therefore an important public health objective. Relatively little is known about changes in physical activity behavior over the life course, the domains of physical activity in which they o...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwp273
更新日期:2009-11-01 00:00:00
abstract::The relation between plasma insulin level and the prevalence of coronary heart disease was studied in a representative nondiabetic population sample of 396 men and 673 women aged 65-74 years in Kuopio, eastern Finland, in 1986-1988. No association between plasma insulin levels and the prevalence of previous myocardial...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116621
更新日期:1993-06-01 00:00:00
abstract::The authors conducted a population-based case-control study of connective tissue disease in a four-county area in southeastern Georgia. Interviews with 44 cases and 88 controls were conducted in September and October of 1986. The association with a family history of these disorders was reconfirmed, and a positive asso...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115348
更新日期:1989-08-01 00:00:00
abstract::We conducted a retrospective study among 4,734 women who served in the US military in Vietnam (Vietnam cohort), 2,062 women who served in countries near Vietnam (near-Vietnam cohort), and 5,313 nondeployed US military women (US cohort) to evaluate the associations of mortality outcomes with Vietnam War service. Vetera...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt319
更新日期:2014-03-15 00:00:00
abstract::A repeatability study of dietary intake has been carried out using 94 control subjects from a previously reported case-control study of diet and colorectal cancer. Dietary histories readministered on average seven years after an initial interview were used to estimate intake of various macro- and microdietary componen...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115146
更新日期:1989-02-01 00:00:00
abstract::Eighty-eight cases with newly diagnosed carcinoma of the endometrium and 177 age-matched neighborhood controls were interviewed to test the hypothesis that exogenous estrogens lead to an increased risk of endometrial cancer. Forth-five per cent of the cases and 22% of the controls reported a history of estrogen use wh...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113215
更新日期:1981-10-01 00:00:00
abstract::Obesity, android fat distribution, and other anthropometric measures have been associated with coronary heart disease in long-term prospective studies. However, fluctuations in weight due to age-related hormonal changes and changes in lifestyle practices may bias relative risk estimates over a long follow-up period. T...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117385
更新日期:1995-06-15 00:00:00
abstract::Salmonella is a common cause of bacterial foodborne illness in the United States. The epidemiology and costs of nontyphoidal salmonellosis in California from 1990 through 1999 are described using surveillance, hospitalization, and death data. Trends in Salmonella rates and factors associated with prolonged hospitaliza...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf155
更新日期:2003-01-01 00:00:00
abstract::To determine risk factors for Ewing's bone sarcoma, the authors interviewed mothers of 43 patients diagnosed between January 1978 and August 1986 and 193 controls in the San Francisco Bay Area, California, regarding medical and occupational history of parents and other factors related to the subjects and their immedia...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116265
更新日期:1992-01-15 00:00:00
abstract::Serum hemagglutination-inhibition (HI) antibody titers were monitored for five years with samples from 79 keratoconjunctivitis patients with type 8 adenovirus (AV-8) infection. Geometric mean antibody titers declined from 1:161 at the peak of the epidemic to 1:56 after five years. Computerized analysis of the decline ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112797
更新日期:1979-08-01 00:00:00
abstract::Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military p...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp238
更新日期:2009-10-15 00:00:00
abstract::Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationall...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm075
更新日期:2007-08-01 00:00:00
abstract::Dietary data from 11,658 adult respondents in the second National Health and Nutrition Examination Survey were used to provide quantitative information regarding the contribution of specific foods to the total population intake of the following 10 nutrients: vitamin A, thiamine, riboflavin, niacin, vitamin C, iron, ph...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114072
更新日期:1985-07-01 00:00:00
abstract::Vaccinating children with pneumococcal conjugate vaccine (PCV) disrupts transmission, reducing disease rates in unvaccinated adults. When considering changes in vaccine dosing strategies (e.g., removing doses), it is critical to understand which groups of children contribute most to transmission to adults. We used dat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwy219
更新日期:2019-01-01 00:00:00
abstract::Ecologic (aggregate) data are widely available and widely utilized in epidemiologic studies. However, ecologic bias, which arises because aggregate data cannot characterize within-group variability in exposure and confounder variables, can only be removed by supplementing ecologic data with individual-level data. Here...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm386
更新日期:2008-04-15 00:00:00
abstract::During a three-week period in 1984, 339 tourists and expatriate employees with diarrhea visited the infirmary at a Caribbean resort club. Epidemiologic studies suggested that over 60% of the 1,893 tourists at the resort club during that time may have been ill. Shigella flexneri 4a was isolated from seven of 18 stool s...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114755
更新日期:1987-12-01 00:00:00
abstract::For determination of the effects of weight variability on cardiovascular risk factors, a random community sample of 269 men and 361 women aged 25-74 years, drawn from the Stanford Five-City Project, was followed for up to 10 years (1979-1989). Systolic and diastolic blood pressure, total and high density lipoprotein c...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117448
更新日期:1995-03-01 00:00:00
abstract::Despite the resulting loss of information, continuous exposure variables are often categorized in epidemiologic data analysis. It has been shown that nondifferential measurement error of exposure can lead to differential misclassification under these circumstances. This paper extends these findings to the misclassific...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116877
更新日期:1993-09-15 00:00:00
abstract::Recent studies suggest that both active and passive smokers have an increased risk of breast cancer compared with women who have never been either actively or passively exposed. Data on lifetime active and passive smoking were collected in 1999-2000 from 468 predominantly premenopausal breast cancer patients diagnosed...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwf093
更新日期:2002-10-01 00:00:00
abstract::In 1989, the authors tested the effectiveness of two response-enhancing techniques, a postage stamped or franked return envelope and a prenotification letter, in a survey of pregnancy among 10,047 resident physicians in the United States. The techniques were randomly assigned using a factorial design. No significant i...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/oxfordjournals.aje.a116126
更新日期:1991-09-01 00:00:00
abstract::To examine the association between alcohol consumption and mortality in Japan, where mortality and lifestyle differ substantially from Western countries, a population-based prospective study was conducted in four public health center areas as part of the Japan Public Health Center-based prospective study on cancer and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009946
更新日期:1999-12-01 00:00:00
abstract::The potential role of psychological stress in pancreatic cancer has rarely been investigated in epidemiologic studies. During 1991-2009, we conducted a nested case-control study based on Swedish national population and health registers to investigate whether severe psychological stress induced by the death of a child ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt045
更新日期:2013-08-15 00:00:00
abstract::Relations between diet and nuclear opacities in the lens of the eye were investigated in a population-based cohort of middle-aged and older adults who lived in Beaver Dam, Wisconsin. Nuclear sclerosis was assessed from photographs of the lens taken during 1988-1990 in 1,919 persons in the Beaver Dam Eye Study. Diets i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/141.4.322
更新日期:1995-02-15 00:00:00
abstract::The authors conducted an investigation to determine the extent and source of an outbreak of Salmonella typhimurium gastroenteritis that occurred following a community picnic in Juneau, Alaska, in 1992, and to evaluate risk factors for illness. A case-control study among 54 picnic attendees and a retrospective cohort s...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117096
更新日期:1994-05-01 00:00:00
abstract::A community sample made in the fall of 1972 in Durham County, North Carolina, and that consisted of 331 persons 65 years of age and older was assessed for adequacy of social support along three parameters: roles and available attachments, perceived social support, and frequency of social interaction. This approach to ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113351
更新日期:1982-05-01 00:00:00
abstract::Above-average exposure to electromagnetic fields has been associated with certain nonmalignant medical conditions such as amyotrophic lateral sclerosis, other neurologic diseases, depressive symptoms, and suicide. The authors conducted a nationwide mortality study in Denmark of 21,236 men employed in utility companies...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009654
更新日期:1998-08-15 00:00:00
abstract::In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwn136
更新日期:2008-08-01 00:00:00