Abstract：
:Evidence from animal and cell models suggests that pesticides cause a neurodegenerative process leading to Parkinson's disease (PD). Human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. The authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from California Pesticide Use Reports and land-use maps to estimate historical exposure to agricultural pesticides in the residential environment. In 1998-2007, the authors enrolled 368 incident PD cases and 341 population controls from the Central Valley of California in a case-control study. They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999. Exposure to both pesticides within 500 m of the home increased PD risk by 75% (95% confidence interval (CI): 1.13, 2.73). Persons aged < or =60 years at the time of diagnosis were at much higher risk when exposed to either maneb or paraquat alone (odds ratio = 2.27, 95% CI: 0.91, 5.70) or to both pesticides in combination (odds ratio = 4.17, 95% CI: 1.15, 15.16) in 1974-1989. This study provides evidence that exposure to a combination of maneb and paraquat increases PD risk, particularly in younger subjects and/or when exposure occurs at younger ages.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Costello S,Cockburn M,Bronstein J,Zhang X,Ritz Bdoi
10.1093/aje/kwp006subject
Has Abstractpub_date
2009-04-15 00:00:00pages
919-26issue
8eissn
0002-9262issn
1476-6256pii
kwp006journal_volume
169pub_type
杂志文章abstract：:In November 1986, a statewide outbreak of Escherichia coli O157:H7 infections in Washington State was identified after a physician in an eastern Washington community hospitalized three patients with hemorrhagic colitis which progressed to thrombotic thrombocytopenic purpura. Epidemiologic investigation identified 37 c...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115653
更新日期：1990-08-01 00:00:00
abstract：:It has been suggested that paternal occupational exposures to pesticides and solvents increase the risk of neural tube defects in offspring. With the use of Texas livebirth, fetal death, and linked livebirth-death records, the authors conducted a population-based case-control study among 1981-1986 Texas births to exam...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115526
更新日期：1990-03-01 00:00:00
abstract：:Previous studies have compared calipers for propensity score (PS) matching, but none have considered calipers for matching on the disease risk score (DRS). We used Medicare claims data to perform 3 cohort studies of medication initiators: a study of raloxifene versus alendronate in 1-year nonvertebral fracture risk, a...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwv302
更新日期：2016-05-15 00:00:00
abstract：:The relationship of menopause to associated factors of atherosclerosis was investigated during October 1973 to December 1976. The subjects were 1674 premenopausal and 428 postmenopausal women aged 35 to 54, who were living in Toda city, an urban area of Japan. Serum cholesterol and triglyceride were higher in postmeno...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112699
更新日期：1979-04-01 00:00:00
abstract：:The association between serum selenium concentration and five-year risk of cardiovascular disease was studied in 1,110 men aged 55 to 74 years in two rural areas of Finland. In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 micrograms/liter, an a...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114099
更新日期：1985-08-01 00:00:00
abstract：:Medical devices play a vital role in diagnosing, treating, and preventing diseases and are an integral part of the health-care system. Many devices, including implantable medical devices, enter the market through a regulatory pathway that was not designed to assure safety and effectiveness. Several recent studies and ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwu206
更新日期：2014-11-01 00:00:00
abstract：:The relation of adenocarcinoma of the facial sinuses and exposure to wood dust has been recognized for 20 years. As the tracheobronchial mucosa is similar to that lining the sinuses, a link between bronchial adenocarcinoma and wood dust exposure has been postulated. To test this hypothesis, a case-control study was co...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a115444
更新日期：1989-12-01 00:00:00
abstract：:Unbiased estimation of causal parameters from marginal structural models (MSMs) requires a fundamental assumption of no unmeasured confounding. Unfortunately, the time-varying covariates used to obtain inverse probability weights are often error-prone. Although substantial measurement error in important confounders is...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kww068
更新日期：2016-08-01 00:00:00
abstract：:Data from 12 US case-control studies of ovarian cancer, conducted during the period 1956-1986 and representing some 3,000 cases and 10,000 controls, were pooled and reanalyzed. Separate analyses were conducted for four subgroups of the pooled data: invasive epithelial ovarian cancers in white women; epithelial ovarian...
journal_title：American journal of epidemiology
pub_type： 杂志文章,meta分析
doi：10.1093/oxfordjournals.aje.a116426
更新日期：1992-11-15 00:00:00
abstract：:When waist circumference is taken into account, larger hip circumference is associated with reduced risk factors for diabetes and cardiovascular disease. The authors investigated the prospective association of hip circumference with type 2 diabetes and coronary heart disease (CHD) incidence in a biracial cohort of men...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwn395
更新日期：2009-04-01 00:00:00
abstract：:An increased risk of death in persons who have suffered spousal bereavement has been described in many populations. The impact of modifying factors, such as chronic disease and material circumstances, is less well understood. The authors followed 171,720 [corrected] couples 60 years of age or older in a United Kingdom...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kws162
更新日期：2012-10-15 00:00:00
abstract：:Among the most striking epidemiologic characteristics of prostatic cancer in the United States is the sizeable excess in rates for the disease among blacks as compared with whites. This study attempted to determine whether the higher black rates might be explained by controlling for social class, using mortality data ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112546
更新日期：1978-04-01 00:00:00
abstract：:A large body size may differentially influence risk of colorectal cancer (CRC) by anatomic location. The Netherlands Cohort Study includes 120,852 men and women aged 55-69 years who self-reported weight, height, and trouser/skirt size at baseline (1986), as well as weight at age 20 years. Derived variables included bo...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwr247
更新日期：2011-11-15 00:00:00
abstract：:The identity of the etiologic agent that caused the 1981 epidemic of toxic oil syndrome in Spain has not been established, and toxicologic study of oil specimens from the outbreak has been hampered by uncertainty about which oils were actually capable of causing illness. To identify chemical characteristics associated...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a114914
更新日期：1988-06-01 00:00:00
abstract：:The state of pneumococcal carriage-that is, pneumococcal colonization in the nasopharynx of healthy persons-represents a reservoir for the spread of pneumococci among individuals. In light of the introduction of new pneumococcal conjugate vaccines, further knowledge on the dynamics of pneumococcal carriage is importan...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp351
更新日期：2010-01-15 00:00:00
abstract：:The epidemiology of melanoma in populations of African-European descent has rarely been reported. The authors studied melanoma in the French West Indies (Martinique), where black Caribbeans and whites represented 96% and 4% of the population, respectively. Among the 85 cases of melanoma collected from 1976 to 1995, bl...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009368
更新日期：1998-01-01 00:00:00
abstract：:Pesticides are ubiquitous neurotoxicants, and several lines of evidence suggest that exposure may be associated with depression. Epidemiologic evidence has focused largely on organophosphate exposures, while research on other pesticides is limited. We collected detailed pesticide use history from farmers recruited in ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwt089
更新日期：2013-10-01 00:00:00
abstract：:Cancer rates are often compared between counties or other geographic units as a method of testing for risk from environmental exposures. Migration between geographic areas greatly reduces the sensitivity of this method. Under simplifying assumptions the quantitative effect of migration on risk estimates is shown using...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112885
更新日期：1980-02-01 00:00:00
abstract：:Stroke mortality is reported to be greater in blacks than in whites, but stroke incidence data for blacks and Hispanics are sparse. The aim of this study was to determine and compare stroke incidence rates among whites, blacks, and Hispanics living in the same urban community. A population-based incidence study was co...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009445
更新日期：1998-02-01 00:00:00
abstract：:Recently, independent factors representing different features of insulin resistance syndrome (Syndrome X) have been identified by factor analysis in middle-aged and elderly adult populations. In this study, factor analysis was applied to the clustering characteristics of Syndrome X in a biracial (Black-White) communit...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010069
更新日期：1999-10-01 00:00:00
abstract：:Cigarette smoking is becoming increasingly common in Asia while quitting remains rare, in part because of a lack of knowledge about the risks of smoking. This study compared the risk of death from lung cancer associated with smoking habits in Australia and New Zealand and in Asia by using data from the Asia Pacific Co...
journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1093/aje/kwm002
更新日期：2007-06-01 00:00:00
abstract：:Accurate measurement of central fat patterning is difficult to obtain by conventional anthropometry. Direct measurement of intra-abdominal fat area by magnetic resonance imaging, while accurate, is impractical for large-scale observational studies. This report examines the sex-specific associations of conventional ant...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008934
更新日期：1996-08-15 00:00:00
abstract：:The preterm delivery rate in North Carolina is consistently higher than the national average. However, recent reports suggest that singleton preterm delivery rates for non-Hispanic Whites are increasing while those for non-Hispanic African Americans are decreasing. To study this pattern further, the authors examined d...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwh011
更新日期：2004-01-01 00:00:00
abstract：:Prolonged sitting time is associated with several health outcomes; limited evidence indicates associations with frailty. Our aims in this study were to identify patterns of sitting time over 12 years in middle-aged (ages 50-55 years) women and examine associations of these patterns with frailty in older age. We examin...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwy111
更新日期：2018-11-01 00:00:00
abstract：:Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwm268
更新日期：2007-12-01 00:00:00
abstract：:The authors studied immune response and exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) among veterans of Operation Ranch Hand, the US Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. A comparison group of Air Force veterans who served in Southeast Asia but were n...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009749
更新日期：1999-06-01 00:00:00
abstract：:In this issue of the Journal, Van Ewijk et al. (Am J Epidemiol. 2013;177(8):729-736) report intriguing associations between prenatal exposure to the religious month of Ramadan and body anthropometry among adult Muslims in Indonesia. They categorized prenatal exposure according to the relative timing of Ramadan and the...
journal_title：American journal of epidemiology
pub_type： 评论,杂志文章
doi：10.1093/aje/kwt024
更新日期：2013-04-15 00:00:00
abstract：:Vaccinating school-aged children against influenza can reduce age-specific and population-level illness attack rates. Using a stochastic simulation model of influenza transmission, the authors assessed strategies for vaccinating children in the United States, varying the vaccine type, coverage level, and reproductive ...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwp237
更新日期：2009-09-15 00:00:00
abstract：:To study the role of nutrition in the association of birth size and childhood growth with development of cardiovascular disease, the authors in 2002-2004 surveyed 665 men and 790 women aged 25-42 years who had been exposed as children to a community-randomized nutrition supplementation intervention in four villages in...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/aje/kwj328
更新日期：2006-12-15 00:00:00
abstract：:The possibility that hepatitis B is transmitted venereally was examined by determining the prevalence of hepatitis B antibody (anti-HB(S)) in populations with different levels of promiscuity. Of 258 prostitutes, 31% were anti-HB(S) positive, compared to 10% of 258 female age-matched blood donors, 10% of 48 nuns living...
journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a112153
更新日期：1975-09-01 00:00:00
