Abstract:
:Pesticides are ubiquitous neurotoxicants, and several lines of evidence suggest that exposure may be associated with depression. Epidemiologic evidence has focused largely on organophosphate exposures, while research on other pesticides is limited. We collected detailed pesticide use history from farmers recruited in 1998-2000 in France. Among 567 farmers aged 37-78 years, 83 (14.6%) self-reported treatment or hospitalization for depression. On the basis of the reported age at the first such instance, we used adjusted Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for depression (first treatment or hospitalization) by exposure to different pesticides. The hazard ratio for depression among those who used herbicides was 1.93 (95% confidence interval (CI): 0.95, 3.91); there was no association with insecticides or fungicides. Compared with nonusers, those who used herbicides for <19 years and ≥19 years (median for all herbicide users, 19 years) had hazard ratios of 1.51 (95% CI: 0.62, 3.67) and 2.31 (95% CI: 1.05, 5.10), respectively. Similar results were found for total hours of use. Results were stronger when adjusted for insecticides and fungicides. There is widespread use of herbicides by the general public, although likely at lower levels than in agriculture. Thus, determining whether similar associations are seen at lower levels of exposure should be explored.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Weisskopf MG,Moisan F,Tzourio C,Rathouz PJ,Elbaz Adoi
10.1093/aje/kwt089subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1051-8issue
7eissn
0002-9262issn
1476-6256pii
kwt089journal_volume
178pub_type
杂志文章abstract::Epidemiologic research that uses administrative records (rather than registries or clinical surveys) to identify cases for study has been increasingly restricted because of concerns about privacy, making unbiased population-based research less practicable. In their article, Nattinger et al. (Am J Epidemiol. 2010;172(6...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwq219
更新日期:2010-09-15 00:00:00
abstract::Inflammatory processes are known to drive the pathogenesis of several chronic diseases, including cardiovascular disease and Alzheimer disease, as well as all-cause mortality. Emerging research indicates that women who have a longer reproductive life span-roughly determined as the period from menarche to menopause or ...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwz266
更新日期:2020-07-01 00:00:00
abstract::Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis and function that might produce a decrease in mtDNA content within cells. This implies that mtDNA content might be a potential biomarker associated with oxidative stress and inflammation. However, data on correlates of...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwv175
更新日期:2016-01-15 00:00:00
abstract::The effects of estrogen replacement therapy on prognosis in women with established coronary disease remain uncertain. The authors conducted a retrospective cohort study of 726 women (mean age, 66.2 years) who survived first myocardial infarction to hospital discharge from 1980 through 1991, while enrolled at Group Hea...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009100
更新日期:1997-02-01 00:00:00
abstract::The relation of oral contraceptive (OC) use to the risk of hospitalization for myocardial infarction (MI) was evaluated among 121,964 US nurses who responded to a mail questionnaire. There were 156 women who reported having been hospitalized for MI before the menopause, and 23 (15%) were OC users at the time of the MI...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112874
更新日期:1980-01-01 00:00:00
abstract::The authors present results from a novel approach to understanding recent secular trends in overweight in terms of changes in underlying component distributions. On the basis of an examination of two large overlapping samples of Danish young men (ns = 16,557 and 21,747) spanning birth cohorts 1939-1958, the authors fo...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115917
更新日期:1991-03-01 00:00:00
abstract::To examine the interrelationships of cigarette smoking, relative weight, and the occurrence of natural menopause, the authors prospectively evaluated the experience of 66,663 female US registered nurses who were premenopausal in 1976. Over a two-year period, 5004 women became post-menopausal. Current smokers were more...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113598
更新日期:1983-06-01 00:00:00
abstract::During 1946-2005, vaccine-preventable diseases were the topic of approximately 20% of all epidemic-assistance investigations by the Centers for Disease Control and Prevention. Both in the United States and abroad, current and former Epidemic Intelligence Service officers have played a critical role in describing the e...
journal_title:American journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1093/aje/kwr306
更新日期:2011-12-01 00:00:00
abstract::The presence of tuberculosis (TB) in patients with silicosis increases mortality risk. To characterize silicosis-respiratory TB comortality in the United States, the authors used 1968-2006 National Center for Health Statistics multiple cause-of-death data for decedents aged ≥25 years. The authors calculated proportion...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr159
更新日期:2011-10-01 00:00:00
abstract::In Finland since the 1980s, coronary heart disease mortality has declined more than might be predicted by risk factor reductions alone. The aim of this study was to assess how much of the decline could be attributed to improved treatments and risk factor reductions. The authors used the cell-based IMPACT mortality mod...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi274
更新日期:2005-10-15 00:00:00
abstract::Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a m...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwy083
更新日期:2018-09-01 00:00:00
abstract::The authors abstracted a sample of 7,536 hospital medical records to validate the accuracy of the coding of obstetric information on 1) birth certificates, 2) a statewide computerized hospital discharge abstract data system, and 3) a linked file merging birth certificates and the hospital abstract data for Washington ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116834
更新日期:1993-07-15 00:00:00
abstract::We examined whether early gestational exposures to pesticides were associated with an increased risk of anencephaly, spina bifida, cleft lip with or without cleft palate (CLP), or cleft palate only. We used population-based data along with detailed information from maternal interviews. Exposure estimates were based on...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwt324
更新日期:2014-03-15 00:00:00
abstract::To assess the long-term health consequences of the 1991 Persian Gulf War, the authors compared cause-specific mortality rates of 621,902 Gulf War veterans with those of 746,248 non-Gulf veterans, by gender, with adjustment for age, race, marital status, branch of service, and type of unit. Vital status follow-up began...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.5.399
更新日期:2001-09-01 00:00:00
abstract::Leisure-time physical activity enhances health and functioning in older populations. However, few data are available on the correlation between self-reported leisure-time physical activity and cardiorespiratory fitness in the elderly. Treadmill exercise testing results were obtained for 1,006 members (median age 67 ye...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009382
更新日期:1998-05-15 00:00:00
abstract::Mortality rates of coronary heart disease are much lower and hemorrhagic stroke rates are higher in Japanese than in Caucasians. To investigate whether population differences in plasma concentrations of coagulation factors are consistent with these mortality differences, the authors examined, in 1987, a total of 136 m...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a115425
更新日期:1989-11-01 00:00:00
abstract::The incidence of clinically recognized coronary heart disease and its relation to risk factors have been studied for 596 sibships in the Framingham Heart Study cohort. Only the 186 pairs of brothers were considered in the multivariate analysis, since the rate of coronary heart disease in women is low. Multiple logisti...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113293
更新日期:1982-02-01 00:00:00
abstract::Despite the high prevalence of diabetes mellitus, little is known about mortality associated with diabetes in Asia. Therefore, the authors followed 3,492 Chinese, Malay, and Asian Indian adults randomly selected from the general population in Singapore. Data on glucose tolerance, demographic characteristics, and other...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg199
更新日期:2003-09-15 00:00:00
abstract::High prevalences of anencephaly and neural tube defects (NTDs) have recently been recorded for several Texas counties bordering Mexico. In addition, a few investigators have reported Hispanics to be at elevated risk for NTDs (anencephaly and spina bifida). Factors contributing to this risk have not been established. T...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a008647
更新日期:1996-01-01 00:00:00
abstract::The authors investigated whether red blood cell distribution width (RDW) was associated with the development of cardiovascular disease (CVD) events and mortality in a community cohort in Taiwan. The influence of anemia on the association was also assessed. RDW levels were measured in 3,226 participants aged 35 years o...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp360
更新日期:2010-01-15 00:00:00
abstract::In a 1994-1998 cross-sectional study of a multiethnic sample of 2,211 men and women in San Diego, California, the authors estimated prevalence of the major manifestations of chronic venous disease: spider veins, varicose veins, trophic changes, and edema by visual inspection; superficial and deep functional disease (r...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg166
更新日期:2003-09-01 00:00:00
abstract::The authors examined the relation between age at first vaginal intercourse and a positive nucleic acid amplification test for sexually transmitted infection (STI). A nationally representative sample of 9,844 respondents aged 18-26 years was tested for chlamydial infection, gonorrhea, and trichomoniasis in wave 3 (2001...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi095
更新日期:2005-04-15 00:00:00
abstract::To develop a method for assessing preclinical cardiovascular disease risk, models of resting cardiovascular regulation and of insulin metabolic syndrome were derived from information collected from 1991 to 1996 in a culturally heterogeneous sample of 319 healthy men and women (aged 25-44 years) from Miami-Dade County,...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/154.8.765
更新日期:2001-10-15 00:00:00
abstract::The possibility that hepatitis B is transmitted venereally was examined by determining the prevalence of hepatitis B antibody (anti-HB(S)) in populations with different levels of promiscuity. Of 258 prostitutes, 31% were anti-HB(S) positive, compared to 10% of 258 female age-matched blood donors, 10% of 48 nuns living...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112153
更新日期:1975-09-01 00:00:00
abstract::Low blood pressure during pregnancy has been associated with poor perinatal outcomes. However, whether this association is causal or is due to confounding has never been carefully assessed. The authors used data from the Collaborative Perinatal Project, a large prospective cohort study in 12 hospitals in the United St...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/153.7.642
更新日期:2001-04-01 00:00:00
abstract::From 1996 to 2001, the authors undertook a case-control study of 192 pelvis fracture cases (men and women) and 2,402 controls aged > or = 45 years at five Kaiser Permanente medical centers in Northern California. Most information on potential risk factors was obtained by means of an interviewer-administered questionna...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwi295
更新日期:2005-11-01 00:00:00
abstract::To evaluate the risk of another cancer among persons who initially developed Kaposi's sarcoma, the authors used data from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute for the years 1973-1990. In persons under 70 years of age, 4,946 cases of Kaposi's sarcoma were obser...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a117008
更新日期:1994-02-15 00:00:00
abstract::Many neural tube defects can be prevented if women take folic acid around the time of conception. However, the majority of women do not take folic acid at the critical time, so the US government required that food be fortified with folic acid effective January 1, 1998. Whether the amount being added was sufficient to ...
journal_title:American journal of epidemiology
pub_type: 评论,杂志文章
doi:10.1093/aje/kwn329
更新日期:2009-01-01 00:00:00
abstract::Evidence suggests a role for progesterone in ovarian cancer development. Progesterone exerts its effect on target cells by interacting with its receptor. Thus, genetic variations that may cause alterations in the biologic functions of the progesterone receptor can potentially contribute to individual susceptibility to...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwi064
更新日期:2005-03-01 00:00:00
abstract::Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisom...
journal_title:American journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/aje/kwi174
更新日期:2005-07-15 00:00:00