Acute-on-Chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics.

Abstract:

:Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a multicenter prospective cohort with the same inclusion criteria and disease indicators as those used in the European Consortium Acute-on-Chronic Liver Failure in Cirrhosis Study is urgently needed in Asia, where the prevalence of HBV is high. A multicenter prospective cohort of 2,600 patients was designed, drawing from 14 nationwide liver centers from tertiary university hospitals in China, and 2,600 hospitalized patients with chronic liver disease (both cirrhotic and noncirrhotic) of various etiologies with acute decompensation or acute hepatic injury were continuously recruited from January 2015 to December 2016. Data were collected during hospitalization, and follow-ups were performed once a month, with plans to follow all patients until 36 months after hospital discharge. Of these patients, 1,859 (71.5%) had HBV-related disease, 1,833 had cirrhotic disease, and 767 had noncirrhotic disease. The numbers and proportions of enrolled patients from each participating center and the baseline characteristics of the patients with or without cirrhosis are presented.

journal_name

Am J Epidemiol

authors

Gu WY,Xu BY,Zheng X,Chen J,Wang XB,Huang Y,Gao YH,Meng ZJ,Qian ZP,Liu F,Lu XB,Shang J,Li H,Wang SY,Sun X,Li H

doi

10.1093/aje/kwy083

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1829-1839

issue

9

eissn

0002-9262

issn

1476-6256

pii

4995331

journal_volume

187

pub_type

杂志文章,多中心研究
  • Endemic cholera in rural Bangladesh, 1966-1980.

    abstract::Since 1963, the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), formerly the Cholera Research Laboratory, has maintained a field station in Matlab to treat patients from a surveillance population of 240,000 who have cholera and other diarrheal diseases. Since 1966, the authors have analyzed...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113498

    authors: Glass RI,Becker S,Huq MI,Stoll BJ,Khan MU,Merson MH,Lee JV,Black RE

    更新日期:1982-12-01 00:00:00

  • Magnesium in drinking water and death from acute myocardial infarction.

    abstract::The relation between death from acute myocardial infarction and the level of magnesium in drinking water was examined using mortality registers and a case-control design. The study area comprised 17 municipalities in the southern part of Sweden that have different magnesium levels in the drinking water. Cases were men...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008765

    authors: Rubenowitz E,Axelsson G,Rylander R

    更新日期:1996-03-01 00:00:00

  • Hepatitis Ain Greenland: importance of specific antibody testing in epidemiologic surveillance.

    abstract::An epidemic of viral hepatitis type A in an arctic area is described. From 1970-1974, 4961 clinical cases of hepatitis were reported in Greenland, corresponding to 11 per cent of the total population. Epidemiologic surveillance indicated person-to-person transmission of the disease, apparently by the oralfecal route. ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112366

    authors: Skinhoj P,Mikkelsen F,Hollinger FB

    更新日期:1977-02-01 00:00:00

  • Low dehydroepiandrosterone and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study.

    abstract::The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) have been characterized as "protective" against ischemic heart disease (IHD), especially in men, on the basis of sparse epidemiologic evidence. The authors used data from the Massachusetts Male Aging Study, a random sample prospective study of 1...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/153.1.79

    authors: Feldman HA,Johannes CB,Araujo AB,Mohr BA,Longcope C,McKinlay JB

    更新日期:2001-01-01 00:00:00

  • Physical activity and mortality: is the association explained by genetic selection?

    abstract::Public health recommendations promote physical activity to improve health and longevity. Recent data suggest that the association between physical activity and mortality may be due to genetic selection. Using data on twins, the authors investigated whether genetic selection explains the association between physical ac...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm132

    authors: Carlsson S,Andersson T,Lichtenstein P,Michaëlsson K,Ahlbom A

    更新日期:2007-08-01 00:00:00

  • Relation of cigarette smoking to 25-year mortality in middle-aged men with low baseline serum cholesterol: the Chicago Heart Association Detection Project in Industry.

    abstract::It has been suggested that smoking does not influence risk of cardiovascular diseases in populations with low serum cholesterol levels. To determine whether cigarette smoking is an independent risk factor among men with low levels of serum cholesterol, data on 25-year coronary, cardiovascular, and all-cause mortality ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.4.354

    authors: Blanco-Cedres L,Daviglus ML,Garside DB,Liu K,Pirzada A,Stamler J,Greenland P

    更新日期:2002-02-15 00:00:00

  • Estimating the population prevalence of injection drug use and infection with human immunodeficiency virus among injection drug users in Glasgow, Scotland.

    abstract::Although data on the prevalence of injection drug use are an essential prerequisite for estimating the number of individuals infected with the human immunodeficiency virus (HIV), there have been few attempts to utilize statistical methods of population estimation based on multiple data sources. Data on 3,670 cases (2,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116843

    authors: Frischer M,Leyland A,Cormack R,Goldberg DJ,Bloor M,Green ST,Taylor A,Covell R,McKeganey N,Platt S

    更新日期:1993-08-01 00:00:00

  • Simulation study of confounder-selection strategies.

    abstract::In the absence of prior knowledge about population relations, investigators frequently employ a strategy that uses the data to help them decide whether to adjust for a variable. The authors compared the performance of several such strategies for fitting multiplicative Poisson regression models to cohort data: 1) the "...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116813

    authors: Maldonado G,Greenland S

    更新日期:1993-12-01 00:00:00

  • Selection of controls in case-control studies. III. Design options.

    abstract::Several design options available in the planning stage of case-control studies are examined. Topics covered include matching, control/case ratio, choice of nested case-control or case-cohort design, two-stage sampling, and other methods that can be used for control selection. The effect of potential problems in obtain...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116398

    authors: Wacholder S,Silverman DT,McLaughlin JK,Mandel JS

    更新日期:1992-05-01 00:00:00

  • Association of Scrub Typhus With the Risk of Autoimmune Diseases: A Population-Based Cohort Study.

    abstract::Infection plays a major role in the development of autoimmune diseases. In this study, we investigated the relationship between scrub typhus and systemic autoimmune diseases. We enrolled 6,928 hospitalized patients with scrub typhus between 2000 and 2012 from the Taiwan National Health Insurance Research Database, and...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz074

    authors: Chu KA,Chen W,Hsu CY,Hung YM,Wei JC

    更新日期:2019-07-01 00:00:00

  • Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.

    abstract::Hyperinsulinemia is associated with multiple metabolic disorders including high triglyceride level, low high density lipoprotein (HDL) cholesterol level, hypertension, and impaired glucose tolerance (IGT). This metabolic constellation is also called the insulin resistance syndrome. All previous data on clustering of t...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009272

    authors: Mykkänen L,Haffner SM,Rönnemaa T,Bergman RN,Laakso M

    更新日期:1997-08-15 00:00:00

  • Blood pressure survey on the Navajo Indian reservation.

    abstract::The authors conducted blood pressure screening on the Navajo Indian reservation in northeastern Arizona and northwestern New Mexico. Six hundred forty Navajos over 19 years of age were surveyed at various sites. The mean systolic and diastolic blood pressures in Navajo men and women did not show as great increases wit...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112686

    authors: DeStefano F,Coulehan JL,Wiant MK

    更新日期:1979-03-01 00:00:00

  • Matching evidence about clustered health events with tort law requirements.

    abstract::This paper addresses the use of epidemiologic evidence when a cluster becomes the focus of dispute in court. It is often difficult to prove by a preponderance of the evidence that an exposure for which a defendant is responsible caused the disease or diseases at issue. Thus, in a number of cases plaintiffs have resort...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115793

    authors: Black B

    更新日期:1990-07-01 00:00:00

  • Invited Commentary: The Microbiome and Population Health-Considerations for Enhancing Study Design and Data Analysis in Observational and Interventional Epidemiology.

    abstract::Measurement and characterization of the human microbiome in large population-based human studies has recently become a reality secondary to technological advances in high-throughput DNA sequencing. These advances bring new challenges and knowledge gaps for study planning, data analysis, and interpretation that are nov...

    journal_title:American journal of epidemiology

    pub_type: 评论,杂志文章

    doi:10.1093/aje/kwy063

    authors: Demmer RT

    更新日期:2018-06-01 00:00:00

  • Ewing's bone sarcoma, paternal occupational exposure, and other factors.

    abstract::To determine risk factors for Ewing's bone sarcoma, the authors interviewed mothers of 43 patients diagnosed between January 1978 and August 1986 and 193 controls in the San Francisco Bay Area, California, regarding medical and occupational history of parents and other factors related to the subjects and their immedia...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116265

    authors: Holly EA,Aston DA,Ahn DK,Kristiansen JJ

    更新日期:1992-01-15 00:00:00

  • Natural history of bone loss over 6 years among premenopausal and early postmenopausal women.

    abstract::The aims of this prospective cohort study were to determine rates of premenopausal and early postmenopausal bone loss, age at onset of bone loss, and whether rates of bone loss depend on baseline bone mineral density (BMD). The cohort of 614 women aged 24-44 years at baseline from the longitudinal Michigan Bone Health...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf049

    authors: Bainbridge KE,Sowers MF,Crutchfield M,Lin X,Jannausch M,Harlow SD

    更新日期:2002-09-01 00:00:00

  • Cardiovascular Disease and All-Cause Mortality in Male Twins With Discordant Cardiorespiratory Fitness: A Nationwide Cohort Study.

    abstract::Whether genetic and familial factors influence the association between cardiorespiratory fitness (CRF) and cardiovascular disease (CVD) is unknown. Two cohorts were formed based on data from 1,212,295 men aged 18 years who were conscripted for military service in Sweden during 1972-1996. The first comprised 4,260 twin...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwaa060

    authors: Ballin M,Nordström A,Nordström P

    更新日期:2020-10-01 00:00:00

  • Mortality among US veterans of the Persian Gulf War: 7-year follow-up.

    abstract::To assess the long-term health consequences of the 1991 Persian Gulf War, the authors compared cause-specific mortality rates of 621,902 Gulf War veterans with those of 746,248 non-Gulf veterans, by gender, with adjustment for age, race, marital status, branch of service, and type of unit. Vital status follow-up began...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.5.399

    authors: Kang HK,Bullman TA

    更新日期:2001-09-01 00:00:00

  • Epidemiologic programs for computers and calculators. Exact binomial confidence intervals for the relative risk in follow-up studies with sparsely stratified incidence density data.

    abstract::The authors present a computer program for hypothesis testing and calculation of exact binomial confidence intervals for the adjusted relative risk in follow-up studies involving multiple strata with incidence density (person-time) denominators and small or zero person-count numerators. The program is an extension to ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114535

    authors: Guess HA,Lydick EG,Small RD,Miller LP

    更新日期:1987-02-01 00:00:00

  • A study of repeatability of dietary data over a seven-year period.

    abstract::A repeatability study of dietary intake has been carried out using 94 control subjects from a previously reported case-control study of diet and colorectal cancer. Dietary histories readministered on average seven years after an initial interview were used to estimate intake of various macro- and microdietary componen...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115146

    authors: Jain M,Howe GR,Harrison L,Miller AB

    更新日期:1989-02-01 00:00:00

  • Analyses of injury count data: some do's and don'ts.

    abstract::The analysis of injury data requires different considerations from the analysis of other types of outcomes because an individual can experience the outcome many times. When describing injury patterns using numerator-only data (e.g., proportion of upper-extremity injuries vs. lower-extremity injuries), simple compariso...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp265

    authors: Shrier I,Steele RJ,Hanley J,Rich B

    更新日期:2009-11-15 00:00:00

  • Physical, psychological, and functional comorbidities of multisymptom illness in Australian male veterans of the 1991 Gulf War.

    abstract::Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military p...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwp238

    authors: Kelsall HL,McKenzie DP,Sim MR,Leder K,Forbes AB,Dwyer T

    更新日期:2009-10-15 00:00:00

  • Risk of childhood leukemia associated with vaccination, infection, and medication use in childhood: the Cross-Canada Childhood Leukemia Study.

    abstract::Current hypotheses consonant with the peak in leukemia incidence in early childhood point to an infectious etiology. The authors examined the effect of postnatal exposures predicted to affect early immune functioning, including childhood vaccinations, illness, medication use, and breastfeeding patterns. Children 0-15 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm339

    authors: MacArthur AC,McBride ML,Spinelli JJ,Tamaro S,Gallagher RP,Theriault GP

    更新日期:2008-03-01 00:00:00

  • Association between dietary carbohydrates and body weight.

    abstract::The role of dietary carbohydrates in weight loss has received considerable attention in light of the current obesity epidemic. The authors investigated the association of body mass index (weight (kg)/height (m)(2)) with dietary intake of carbohydrates and with measures of the induced glycemic response, using data from...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi051

    authors: Ma Y,Olendzki B,Chiriboga D,Hebert JR,Li Y,Li W,Campbell M,Gendreau K,Ockene IS

    更新日期:2005-02-15 00:00:00

  • Estimation of the standardized risk difference and ratio in a competing risks framework: application to injection drug use and progression to AIDS after initiation of antiretroviral therapy.

    abstract::There are few published examples of absolute risk estimated from epidemiologic data subject to censoring and competing risks with adjustment for multiple confounders. We present an example estimating the effect of injection drug use on 6-year risk of acquired immunodeficiency syndrome (AIDS) after initiation of combin...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/aje/kwu122

    authors: Cole SR,Lau B,Eron JJ,Brookhart MA,Kitahata MM,Martin JN,Mathews WC,Mugavero MJ,CNICS Research Network.

    更新日期:2015-02-15 00:00:00

  • Weight variability effects: a prospective analysis from the Stanford Five-City Project.

    abstract::For determination of the effects of weight variability on cardiovascular risk factors, a random community sample of 269 men and 361 women aged 25-74 years, drawn from the Stanford Five-City Project, was followed for up to 10 years (1979-1989). Systolic and diastolic blood pressure, total and high density lipoprotein c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117448

    authors: Taylor CB,Jatulis DE,Fortmann SP,Kraemer HC

    更新日期:1995-03-01 00:00:00

  • Are the acute effects of particulate matter on mortality in the National Morbidity, Mortality, and Air Pollution Study the result of inadequate control for weather and season? A sensitivity analysis using flexible distributed lag models.

    abstract::Time-series studies have linked daily variations in nonaccidental deaths with daily variations in ambient particulate matter air pollution, while controlling for qualitatively larger influences of weather and season. Although time-series analyses typically include nonlinear terms for weather and season, questions rema...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi157

    authors: Welty LJ,Zeger SL

    更新日期:2005-07-01 00:00:00

  • Epidemiologic differences between the two varieties of Cryptococcus neoformans.

    abstract::This report of the worldwide distribution of two varieties of Cryptococcus neoformans was drawn from data on 628 clinical isolates and from data on 97 additional isolates from other laboratories. Tests showed that 100% of the cultures from Austria, Belgium, Denmark, France, Germany, Holland, Italy, Switzerland, and Ja...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113861

    authors: Kwon-Chung KJ,Bennett JE

    更新日期:1984-07-01 00:00:00

  • Increased risk for lymphoma and glomerulonephritis in a closed population of cats exposed to feline leukemia virus.

    abstract::Feline leukemia virus (FeLV)-associated diseases were observed in a household in eastern Connecticut having 134 cats over a period of five and a half years. FeLV-positive cats had a much higher mortality rate (34.6 deaths per 1000 cat-months of follow-up) than did FeLV-negative cats (8.9 deaths per 1000 cat-months of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112905

    authors: Francis DP,Essex M,Jakowski RM,Cotter SM,Lerer TJ,Hardy WD Jr

    更新日期:1980-03-01 00:00:00

  • Nested case-control study of lung cancer among chemical workers.

    abstract::A recent cohort mortality study of 19,608 male employees of a major Texas chemical production facility had suggested that they might be at higher risk of lung cancer compared with the male population of the United States or Texas but not with the male population of the five-county area in which they reside. An occupat...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114370

    authors: Bond GG,Flores GH,Shellenberger RJ,Cartmill JB,Fishbeck WA,Cook RR

    更新日期:1986-07-01 00:00:00