Abstract：
:We examined whether early gestational exposures to pesticides were associated with an increased risk of anencephaly, spina bifida, cleft lip with or without cleft palate (CLP), or cleft palate only. We used population-based data along with detailed information from maternal interviews. Exposure estimates were based on residential proximity to agricultural pesticide applications during early pregnancy. The study population derived from the San Joaquin Valley, California (1997-2006). Analyses included 73 cases with anencephaly, 123 with spina bifida, 277 with CLP, and 117 with cleft palate only in addition to 785 controls. A total of 38% of the subjects were exposed to 52 chemical groups and 257 specific chemicals. There were relatively few elevated odds ratios with 95% confidence intervals that excluded 1 after adjustment for relevant covariates. Those chemical groups included petroleum derivatives for anencephaly, hydroxybenzonitrile herbicides for spina bifida, and 2,6-dinitroaniline herbicides and dithiocarbamates-methyl isothiocyanate for CLP. The specific chemicals included 2,4-D dimethylamine salt, methomyl, imidacloprid, and α-(para-nonylphenyl)-ω-hydroxypoly(oxyethylene) phosphate ester for anencephaly; the herbicide bromoxynil octanoate for spina bifida; and trifluralin and maneb for CLP. Adjusted odds ratios ranged from 1.6 to 5.1. Given that such odds ratios might have arisen by chance because of the number of comparisons, our study showed a general lack of association between a range of agricultural pesticide exposures and risks of selected birth defects.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Yang W,Carmichael SL,Roberts EM,Kegley SE,Padula AM,English PB,Shaw GMdoi
10.1093/aje/kwt324subject
Has Abstractpub_date
2014-03-15 00:00:00pages
740-8issue
6eissn
0002-9262issn
1476-6256pii
kwt324journal_volume
179pub_type
杂志文章abstract：:The cross-sectional relation between levels of urinary biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) and levels of blood lead was examined in a study of 645 male participants from a longitudinal study of aging. This stable population of men had initially been recruited from communities in and ...
journal_title：American journal of epidemiology
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更新日期：2008-06-15 00:00:00
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更新日期：1994-04-15 00:00:00
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更新日期：2020-05-05 00:00:00
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更新日期：2016-01-15 00:00:00
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doi：10.1093/aje/kwr331
更新日期：2012-03-01 00:00:00
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更新日期：2012-07-15 00:00:00
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更新日期：1987-02-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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更新日期：1988-07-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,多中心研究
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journal_title：American journal of epidemiology
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更新日期：1994-08-01 00:00:00
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更新日期：1998-01-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1986-03-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a008750
更新日期：1996-02-15 00:00:00
