Abstract:
:The NHLBI Family Heart Study is a multicenter, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD), atherosclerosis, and cardiovascular risk factors. In phase I, 2,000 randomly selected participants and 2,000 with family histories of CHD were identified among 14,592 middle-aged participants in epidemiologic studies. Medical histories from these individuals, their parents, and their siblings were used to calculate family risk scores that compared the number of reported and validated CHD events with the number expected based on the size, sex, and age of family members. A total of 657 families with the highest risk scores and early-onset CHD and 588 randomly sampled families had clinic examinations that included electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, hemostatic factors, insulin, glucose, and routine chemistries. Additional biochemical and genetic studies are being performed on selected participants. Serum, plasma, lymphocytes, red cells, and DNA are stored for future studies, including genotyping of candidate genes and anonymous markers. Contributions of genes, shared and individual environments, and behaviors to variations in risk factors, preclinical atherosclerosis, and CHD will be estimated. Linkage studies, including the quantitative trait loci approach, are planned.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Higgins M,Province M,Heiss G,Eckfeldt J,Ellison RC,Folsom AR,Rao DC,Sprafka JM,Williams Rdoi
10.1093/oxfordjournals.aje.a008709subject
Has Abstractpub_date
1996-06-15 00:00:00pages
1219-28issue
12eissn
0002-9262issn
1476-6256journal_volume
143pub_type
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更新日期:1994-05-01 00:00:00
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