Correlates of Peripheral Blood Mitochondrial DNA Content in a General Population.

Abstract:

:Accumulation of mitochondrial DNA (mtDNA) mutations leads to alterations of mitochondrial biogenesis and function that might produce a decrease in mtDNA content within cells. This implies that mtDNA content might be a potential biomarker associated with oxidative stress and inflammation. However, data on correlates of mtDNA content in a general population are sparse. Our goal in the present study was to describe in a randomly recruited population sample the distribution and determinants of peripheral blood mtDNA content. From 2009 to 2013, we examined 689 persons (50.4% women; mean age = 54.4 years) randomly selected from a Flemish population (Flemish Study on Environment, Genes, and Health Outcomes). Relative mtDNA copy number as compared with nuclear DNA was measured by quantitative real-time polymerase chain reaction in peripheral blood. There was a curvilinear relationship between relative mtDNA copy number and age. mtDNA content slightly increased until the fifth decade of life and declined in older subjects (Page (2) = 0.0002). mtDNA content was significantly higher in women (P = 0.007) and increased with platelet count (P < 0.0001), whereas it was inversely associated with white blood cell count (P < 0.0001). We also observed lower mtDNA content in women using estroprogestogens (P = 0.044). This study demonstrated in a general population that peripheral blood mtDNA content is significantly associated with sex and age. Blood mtDNA content is also influenced by platelet and white blood cell counts and estroprogestogen intake. Further studies are required to clarify the impact of chronic inflammation and hormone therapy on mitochondrial function.

journal_name

Am J Epidemiol

authors

Knez J,Winckelmans E,Plusquin M,Thijs L,Cauwenberghs N,Gu Y,Staessen JA,Nawrot TS,Kuznetsova T

doi

10.1093/aje/kwv175

subject

Has Abstract

pub_date

2016-01-15 00:00:00

pages

138-46

issue

2

eissn

0002-9262

issn

1476-6256

pii

kwv175

journal_volume

183

pub_type

杂志文章
  • Optimizing buccal cell DNA yields in mothers and infants for human leukocyte antigen genotyping.

    abstract::Buccal cells provide a convenient source of DNA for epidemiologic studies. Mouthwash rinses yield a higher quality and quantity of DNA than cytobrushes but are not practical for collection from infants. Although cytobrushes yield sufficient DNA for most genotyping analyses, human leukocyte antigen (HLA) analysis can r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwh171

    authors: Saftlas AF,Waldschmidt M,Logsden-Sackett N,Triche E,Field E

    更新日期:2004-07-01 00:00:00

  • Menarcheal age and spontaneous abortion: a causal connection?

    abstract::Data from a Norwegian investigation on family planning were used to study the relation between menarcheal age and spontaneous abortion rate. Abortion rates were found to be 1.5-2 times higher among women with a menarcheal age of 12 years or less than among those with a menarcheal age of 14 years or more. The possibili...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112953

    authors: Liestøl K

    更新日期:1980-06-01 00:00:00

  • Serum phosphorus levels and the spectrum of ankle-brachial index in older men: the Osteoporotic Fractures in Men (MrOS) study.

    abstract::A higher serum phosphorus level is associated with cardiovascular disease (CVD) events among community-living populations. Mechanisms are unknown. The ankle-brachial index (ABI) provides information on both atherosclerosis and arterial stiffness. In this cross-sectional study (2000-2002), the authors evaluated the ass...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq020

    authors: Meng J,Wassel CL,Kestenbaum BR,Collins TC,Criqui MH,Lewis CE,Cummings SR,Ix JH,Osteoporotic Fractures in Men (MrOS) Study Group.

    更新日期:2010-04-15 00:00:00

  • Depressive symptoms among Mexican Americans: the Hispanic Health and Nutrition Examination Survey.

    abstract::This paper presents findings on depressive symptomatology among 3,118 Mexican-American adults who participated in the Hispanic Health and Nutrition Examination Survey (HHANES). In 1982-1984, the National Institute of Mental Health Center for Epidemiologic Studies Depression Scale was administered to Mexican Americans ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115341

    authors: Mościcki EK,Locke BZ,Rae DS,Boyd JH

    更新日期:1989-08-01 00:00:00

  • Antibody against the hepatitis type B core antigen. A new tool for epidemiologic studies.

    abstract::Four random samples representing populations at low (volunteer blood donors), intermediate, (VD clinic patients), high (family contacts of chronic antigen carriers) and very high (male homosexuals) risk of exposure to HBV were surveyed. Among HBsAg and anti-HBs negative individuals an average of 3.3% were found to be ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112298

    authors: Szmuness W,Hoofnagle JH,Stevens CE,Prince AM

    更新日期:1976-09-01 00:00:00

  • Problems with the assessment of dietary fat in prostate cancer studies.

    abstract::The authors conducted a detailed review of studies on the association between prostate cancer and total dietary fat along with specific fatty acids. Overall, the 29 studies reporting actual dietary fat levels in grams of fat were heterogeneous, suggesting that pooling of the relative risks may be inappropriate. Hetero...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/aje/kwh243

    authors: Dennis LK,Snetselaar LG,Smith BJ,Stewart RE,Robbins ME

    更新日期:2004-09-01 00:00:00

  • Seroresponse to hepatitis B vaccine in patients and staff of renal dialysis centers, Wisconsin.

    abstract::Since June 1982, the Wisconsin Chronic Renal Disease Program has provided reimbursement for hepatitis B virus vaccine and pre- and postvaccine serologic testing for patients and staff in all Wisconsin renal dialysis centers. Between July 1, 1982 and June 30, 1984, 444 dialysis patients in 22 renal dialysis centers and...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114858

    authors: Steketee RW,Ziarnik ME,Davis JP

    更新日期:1988-04-01 00:00:00

  • Education and the risk for Alzheimer's disease: sex makes a difference. EURODEM pooled analyses. EURODEM Incidence Research Group.

    abstract::The hypothesis that a low educational level increases the risk for Alzheimer's disease remains controversial. The authors studied the association of years of schooling with the risk for incident dementia and Alzheimer's disease by using pooled data from four European population-based follow-up studies. Dementia cases ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010149

    authors: Letenneur L,Launer LJ,Andersen K,Dewey ME,Ott A,Copeland JR,Dartigues JF,Kragh-Sorensen P,Baldereschi M,Brayne C,Lobo A,Martinez-Lage JM,Stijnen T,Hofman A

    更新日期:2000-06-01 00:00:00

  • The prevalence at birth of congenital malformations in communities near the Hanford site.

    abstract::The authors examined the prevalence of congenital malformations among births in Benton and Franklin counties, in southeastern Washington State, from 1968 through 1980. The Hanford Site is in this area and serves as a major employer. In addition, various agriculturally and chemically related activities are in the area....

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114800

    authors: Sever LE,Hessol NA,Gilbert ES,McIntyre JM

    更新日期:1988-02-01 00:00:00

  • Effect of early patient enrollment on the time to completion and publication of randomized controlled trials.

    abstract::The authors evaluated whether early enrollment affects the significance of the results and the time to completion and publication of randomized controlled trials. Seventy-seven efficacy randomized controlled trials (total enrollment, 28,992 patients) initiated by the Acquired Immunodeficiency Syndrome Clinical Trials ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.9.873

    authors: Haidich AB,Ioannidis JP

    更新日期:2001-11-01 00:00:00

  • Occupational risk factors for prostate cancer: results from a case-control study in Montréal, Québec, Canada.

    abstract::A population-based case-control study of cancer and occupation was carried out in Montréal, Canada. Between 1979 and 1986, 449 pathologically confirmed cases of prostate cancer were interviewed, as well as 1,550 cancer controls and 533 population controls. Job histories were evaluated by a team of chemist/hygienists u...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008750

    authors: Aronson KJ,Siemiatycki J,Dewar R,Gérin M

    更新日期:1996-02-15 00:00:00

  • Using Bounds to Compare the Strength of Exchangeability Assumptions for Internal and External Validity.

    abstract::In the absence of strong assumptions (e.g., exchangeability), only bounds for causal effects can be identified. Here we describe bounds for the risk difference for an effect of a binary exposure on a binary outcome in 4 common study settings: observational studies and randomized studies, each with and without simple r...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz060

    authors: Breskin A,Westreich D,Cole SR,Edwards JK

    更新日期:2019-07-01 00:00:00

  • Sex-specific associations of magnetic resonance imaging-derived intra-abdominal and subcutaneous fat areas with conventional anthropometric indices. The Atherosclerosis Risk in Communities Study.

    abstract::Accurate measurement of central fat patterning is difficult to obtain by conventional anthropometry. Direct measurement of intra-abdominal fat area by magnetic resonance imaging, while accurate, is impractical for large-scale observational studies. This report examines the sex-specific associations of conventional ant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a008934

    authors: Schreiner PJ,Terry JG,Evans GW,Hinson WH,Crouse JR 3rd,Heiss G

    更新日期:1996-08-15 00:00:00

  • Circulating 25-hydroxyvitamin D3 in relation to renal cell carcinoma incidence and survival in the EPIC cohort.

    abstract::Normal renal function is essential for vitamin D metabolism, but it is unclear whether circulating vitamin D is associated with risk of renal cell carcinoma (RCC). We assessed whether 25-hydroxyvitamin D3 (25(OH)D3) was associated with risk of RCC and death after RCC diagnosis in the European Prospective Investigation...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwu204

    authors: Muller DC,Fanidi A,Midttun Ø,Steffen A,Dossus L,Boutron-Ruault MC,Severi G,Kühn T,Katzke V,de la Torre RA,González CA,Sánchez MJ,Dorronsoro M,Santiuste C,Barricarte A,Khaw KT,Wareham N,Travis RC,Trichopoulou A,Giota

    更新日期:2014-10-15 00:00:00

  • Rates of preterm delivery among Black women and White women in the United States over two decades: an age-period-cohort analysis.

    abstract::The authors assessed the influence of age, period, and cohort effects on rates of preterm delivery in the United States. Rates of preterm delivery for singleton births (<37 weeks) in seven age groups (15-19, 20-24,., 45-49 years), five periods (1975, 1980, 1985, 1990, 1995), and 11 maternal birth cohorts (1926-1930, 1...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/154.7.657

    authors: Ananth CV,Misra DP,Demissie K,Smulian JC

    更新日期:2001-10-01 00:00:00

  • The association between physical activity and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis.

    abstract::Prior reports regarding the association between physical activity and subclinical cardiovascular disease have not been consistent. The authors assessed physical activity and walking pace via questionnaire among 6,482 US adults aged 45-84 years without prior clinical cardiovascular disease participating in the Multi-Et...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn350

    authors: Bertoni AG,Whitt-Glover MC,Chung H,Le KY,Barr RG,Mahesh M,Jenny NS,Burke GL,Jacobs DR

    更新日期:2009-02-15 00:00:00

  • A longitudinal analysis of the influence of the neighborhood built environment on walking for transportation: the RESIDE study.

    abstract::The purpose of the present analysis was to use longitudinal data collected over 7 years (from 4 surveys) in the Residential Environments (RESIDE) Study (Perth, Australia, 2003-2012) to more carefully examine the relationship of neighborhood walkability and destination accessibility with walking for transportation that...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/aje/kwu171

    authors: Knuiman MW,Christian HE,Divitini ML,Foster SA,Bull FC,Badland HM,Giles-Corti B

    更新日期:2014-09-01 00:00:00

  • A co-twin control study of the effects of the Vietnam War on the self-reported physical health of veterans.

    abstract::This study examines the impact of military service on 13 categories of self-reported physical health problems by using a sample of 2,260 American male-male monozygotic twin pairs who served on active duty during the Vietnam War. Data were collected in 1987 by using mail and/or telephone interviews. Twins who served in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115992

    authors: Eisen SA,Goldberg J,True WR,Henderson WG

    更新日期:1991-07-01 00:00:00

  • Bone mineral density and risk of breast cancer: differences by family history of breast cancer. Study of Osteoporotic Fractures Research Group.

    abstract::Recent studies have suggested that bone mineral density (BMD) is related to risk of breast cancer in elderly women. This study investigated whether the level of breast cancer risk associated with BMD in women with a positive family history of breast cancer is different from that in women without a family history of br...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009554

    authors: Lucas FL,Cauley JA,Stone RA,Cummings SR,Vogt MT,Weissfeld JL,Kuller LH

    更新日期:1998-07-01 00:00:00

  • Risk of ovarian cancer in relation to estrogen and progestin dose and use characteristics of oral contraceptives. SHARE Study Group. Steroid Hormones and Reproductions.

    abstract::Although past studies have shown that oral contraceptives with 50 microg or more of estrogen reduce the risk of ovarian cancer, it is not clear whether newer, lower-dose formulations do as well. We conducted a population-based, case-control study in the Delaware Valley to assess the impact of dose of oral contraceptio...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.3.233

    authors: Ness RB,Grisso JA,Klapper J,Schlesselman JJ,Silberzweig S,Vergona R,Morgan M,Wheeler JE

    更新日期:2000-08-01 00:00:00

  • Selection on atherosclerosis as an explanation of the attenuated cholesterol-mortality relation in coronary heart disease populations.

    abstract::Recent studies of patients with coronary heart disease (CHD) at baseline have shown that their cholesterol levels are much less predictive of subsequent mortality than in populations free of CHD (FCHD). One previously suggested explanation of this attenuation is that the impact of hyperlipidemia on atherosclerosis or ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112852

    authors: Cornfield J,Detre K

    更新日期:1979-12-01 00:00:00

  • Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women.

    abstract::High-fiber diets are associated with improved lipid profiles. However, pre- and postmenopausal women respond differently to fiber intake, suggesting that endogenous estradiol mediates the effect. The authors' objective was to determine the direct effect of fiber intake on lipoprotein cholesterol levels independent of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq388

    authors: Mumford SL,Schisterman EF,Siega-Riz AM,Gaskins AJ,Wactawski-Wende J,VanderWeele TJ

    更新日期:2011-01-15 00:00:00

  • Associations of seafood and elongated n-3 fatty acid intake with fetal growth and length of gestation: results from a US pregnancy cohort.

    abstract::Previous studies, mainly among populations with high consumption of seafood, have suggested that increased marine n-3 polyunsaturated fatty acid (PUFA) intake during pregnancy promotes longer gestation and higher birth weight. Few studies have isolated the contribution of fetal growth to birth weight. Using data from ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwh282

    authors: Oken E,Kleinman KP,Olsen SF,Rich-Edwards JW,Gillman MW

    更新日期:2004-10-15 00:00:00

  • Oral contraceptives and ovulatory causes of delayed fertility.

    abstract::The return of fertility for women who discontinue oral contraceptives takes longer as compared with women who discontinue other methods of contraception. It remains unclear, however, whether subsequent fertility differs according to duration or age at first use. The authors performed a nested case-control study within...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009261

    authors: Chasan-Taber L,Willett WC,Stampfer MJ,Spiegelman D,Rosner BA,Hunter DJ,Colditz GA,Manson JE

    更新日期:1997-08-01 00:00:00

  • Using a telephone survey to acquire genetic and behavioral data related to cigarette smoking in "made-anonymous" and "registry" samples.

    abstract::In the Smokers and Nonsmokers Study, the authors investigated the feasibility of using random digit dialing telephone interviews to locate adults in the continental United States who were willing to provide DNA from buccal swabs through the mail. Interviews with 3,383 adults regarding their smoking-related behaviors (...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwf010

    authors: Kozlowski LT,Vogler GP,Vandenbergh DJ,Strasser AA,O'Connor RJ,Yost BA

    更新日期:2002-07-01 00:00:00

  • Genetic Epidemiology and Public Health: The Evolution From Theory to Technology.

    abstract::Genetic epidemiology represents a hybrid of epidemiologic designs and statistical models that explicitly consider both genetic and environmental risk factors for disease. It is a relatively new field in public health; the term was first coined only 35 years ago. In this short time, the field has been through a major e...

    journal_title:American journal of epidemiology

    pub_type: 历史文章,杂志文章

    doi:10.1093/aje/kww001

    authors: Fallin MD,Duggal P,Beaty TH

    更新日期:2016-03-01 00:00:00

  • The importance of biopsychosocial factors in the development of duodenal ulcer in a cohort of middle-aged men.

    abstract::This study prospectively evaluated psychosocial as well as biologic, behavioral, and demographic factors in the development of duodenal ulcer. Baseline data were collected in 1963 on 8,458 Israeli men over age 40 years who had no history of duodenal ulcer. The subjects were followed for 5 years, and 254 reported the d...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116436

    authors: Medalie JH,Stange KC,Zyzanski SJ,Goldbourt U

    更新日期:1992-11-15 00:00:00

  • Acquired immunodeficiency syndrome (AIDS) risk in recent and long-standing human immunodeficiency virus type 1 (HIV-1)-infected patients with similar CD4 lymphocyte counts.

    abstract::The loss of CD4 lymphocytes is known to be an important component of human immunodeficiency virus type 1 (HIV-1) pathogenesis. It remains unclear, however, whether the importance of the CD4 lymphocyte count is such that individuals who have been infected for widely different lengths of time, but for whom the CD4 lymph...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116789

    authors: Phillips AN,Sabin CA,Elford J,Bofill M,Janossy G,Lee CA

    更新日期:1993-11-15 00:00:00

  • Analgesic drug use and risk of epithelial ovarian cancer.

    abstract::Analgesic use may reduce ovarian cancer risk, possibly through antiinflammatory or antigonadotropic effects. The authors conducted a population-based, case-control study in Washington State that included 812 women aged 35-74 years who were diagnosed with epithelial ovarian cancer between 2002 and 2005 and 1,313 contro...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn082

    authors: Hannibal CG,Rossing MA,Wicklund KG,Cushing-Haugen KL

    更新日期:2008-06-15 00:00:00

  • A prospective cohort study of shift work and risk of ischemic heart disease in Japanese male workers.

    abstract::This study prospectively examined the association between shift work and the risk of ischemic heart disease among Japanese male workers. A baseline survey, which involved 110,792 inhabitants (age range: 40-79 years) from 45 areas throughout Japan, was conducted between 1988 and 1990. The causes of death were identifie...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj185

    authors: Fujino Y,Iso H,Tamakoshi A,Inaba Y,Koizumi A,Kubo T,Yoshimura T,Japanese Collaborative Cohort Study Group.

    更新日期:2006-07-15 00:00:00