Genetic Epidemiology and Public Health: The Evolution From Theory to Technology.

Abstract:

:Genetic epidemiology represents a hybrid of epidemiologic designs and statistical models that explicitly consider both genetic and environmental risk factors for disease. It is a relatively new field in public health; the term was first coined only 35 years ago. In this short time, the field has been through a major evolution, changing from a field driven by theory, without the technology for genetic measurement or computational capacity to apply much of the designs and methods developed, to a field driven by rapidly expanding technology in genomic measurement and computational analyses while epidemiologic theory struggles to keep up. In this commentary, we describe 4 different eras of genetic epidemiology, spanning this evolution from theory to technology, what we have learned, what we have added to the broader field of public health, and what remains to be done.

journal_name

Am J Epidemiol

authors

Fallin MD,Duggal P,Beaty TH

doi

10.1093/aje/kww001

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

387-93

issue

5

eissn

0002-9262

issn

1476-6256

pii

kww001

journal_volume

183

pub_type

历史文章,杂志文章
  • Skin infections and immunoglobulin A in serum, sweat, and saliva of patients recovered from poststreptococcal acute glomerulonephritis or acute rheumatic fever and their siblings.

    abstract::Differences in hygienic habits and base-line secretory immunoglobulin (Ig) A which might have contributed to the prevalence of skin infections and/or absence of increased serum IgA values were sought in patients with poststreptococcal acute glomerulonephritis (nephritis) in contrast to patients with acute rheumatic fe...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113382

    authors: Potter EV,Vincente JB,Mayon-WHite RT,Shaughnessy MA,Poon-King T,Earle DP

    更新日期:1982-06-01 00:00:00

  • Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data.

    abstract::Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of indivi...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/aje/kww212

    authors: Rogne T,Tielemans MJ,Chong MF,Yajnik CS,Krishnaveni GV,Poston L,Jaddoe VW,Steegers EA,Joshi S,Chong YS,Godfrey KM,Yap F,Yahyaoui R,Thomas T,Hay G,Hogeveen M,Demir A,Saravanan P,Skovlund E,Martinussen MP,Jacobsen G

    更新日期:2017-02-01 00:00:00

  • Dietary intake related to prevalent functional limitations in midlife women.

    abstract::Physical functioning measures are considered integrated markers of the aging process. This prospective investigation examined relations between dietary intake of women at midlife in 1996-1997 and prevalence of physical functioning limitations 4 years later, defined by the Medical Outcomes Study Short-Form 36. The samp...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm397

    authors: Tomey KM,Sowers MR,Crandall C,Johnston J,Jannausch M,Yosef M

    更新日期:2008-04-15 00:00:00

  • Perceived Stress and Its Relationship With Chronic Medical Conditions and Multimorbidity Among 229,293 Community-Dwelling Adults in 44 Low- and Middle-Income Countries.

    abstract::In this study, we assessed the association of chronic medical conditions and multimorbidity with perceived stress among community-dwelling adults in 44 low- and middle-income countries. Data from the World Health Survey (2002-2004), including 229,293 adults, were analyzed. A perceived stress score (range, 0 (lowest st...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx159

    authors: Vancampfort D,Koyanagi A,Ward PB,Veronese N,Carvalho AF,Solmi M,Mugisha J,Rosenbaum S,De Hert M,Stubbs B

    更新日期:2017-10-15 00:00:00

  • Seroimmunity to poliomyelitis in an American community.

    abstract::In an effort to determine the immune status of individuals in a natural community, neutralizing antibody titers for the three types of poliovirus were examined in 301 randomly sampled sera collected in 1966 and 308 specimens from 1971. The specimens were part of a larger collection obtained from residents of Tecumseh,...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112101

    authors: Oberhofer TR,Brown GC,Monto AS

    更新日期:1975-04-01 00:00:00

  • Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada.

    abstract::In a case-control study of childhood leukemia in relation to exposure to power-frequency electric and magnetic fields (EMF), 399 children resident in five Canadian provinces who were diagnosed at ages 0-14 years between 1990 and 1994 (June 1995 in British Columbia and Quebec) were enrolled, along with 399 controls. Ex...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009899

    authors: McBride ML,Gallagher RP,Thériault G,Armstrong BG,Tamaro S,Spinelli JJ,Deadman JE,Fincham S,Robson D,Choi W

    更新日期:1999-05-01 00:00:00

  • The AIDS epidemic in India: a new method for estimating current human immunodeficiency virus (HIV) incidence rates.

    abstract::Human immunodeficiency virus (HIV) incidence rates in India were estimated using a new method that accounts for follow-up bias. Follow-up bias arises in epidemiologic cohort studies when the incidence rate among individuals who do and do not return for follow-up are different. The new method combines data on the preva...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a117700

    authors: Brookmeyer R,Quinn T,Shepherd M,Mehendale S,Rodrigues J,Bollinger R

    更新日期:1995-10-01 00:00:00

  • Rickettsia tsutsugamushi infection and scrub typhus incidence among Chinese military personnel in the Pescadores Islands.

    abstract::Personnel assigned to infantry units of the army of the Republic of China (Taiwan) stationed in the Pescadores Islands experienced the highest incidence rate of scrub typhus (4%) and the highest rate of Rickettsia tsutsugamushi infection (12%) of the units studied during 1976. The ratio of scrub typhus to infection wi...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112448

    authors: Olson JG,Bourgeois AL

    更新日期:1977-08-01 00:00:00

  • Cohort analysis of malignant melanoma in five countries.

    abstract::Vital statistics data on mortality from malignant melanoma from five countries are simultaneously fit by the method of cohort analysis. After the effects of geographic and temporal trends are removed, the proportion of deaths occurring in the younger age groups is found to be higher in females than in males. Relative ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113726

    authors: Venzon DJ,Moolgavkar SH

    更新日期:1984-01-01 00:00:00

  • Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort.

    abstract::The authors investigated the relations of body mass index at different ages and adult weight change to incident colorectal cancer risk in the prospective National Institutes of Health-AARP Diet and Health Study (1995-1996), using a subcohort with repeated recall weights (273,679 participants; mean baseline age = 62.8 ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws192

    authors: Renehan AG,Flood A,Adams KF,Olden M,Hollenbeck AR,Cross AJ,Leitzmann MF

    更新日期:2012-12-15 00:00:00

  • Progression of human immunodeficiency virus type 1 (HIV-1) infection among homosexual men in hepatitis B vaccine trial cohorts in Amsterdam, New York City, and San Francisco, 1978-1991.

    abstract::The authors evaluated the progression of human immunodeficiency virus type 1 (HIV-1) disease from the date of seroconversion to the development of acquired immunodeficiency syndrome (AIDS) and death among 362 well-documented seroconverters. The participants were homosexual men in hepatitis B vaccine trials in Amsterda...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a116951

    authors: Hessol NA,Koblin BA,van Griensven GJ,Bacchetti P,Liu JY,Stevens CE,Coutinho RA,Buchbinder SP,Katz MH

    更新日期:1994-06-01 00:00:00

  • Variation in child cognitive ability by week of gestation among healthy term births.

    abstract::The authors investigated variations in cognitive ability by gestational age among 13,824 children at age 6.5 years who were born at term with normal weight, using data from a prospective cohort recruited in 1996-1997 in Belarus. The mean differences in the Wechsler Abbreviated Scales of Intelligence were examined by g...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/aje/kwp413

    authors: Yang S,Platt RW,Kramer MS

    更新日期:2010-02-15 00:00:00

  • Risk of ovarian cancer in relation to estrogen and progestin dose and use characteristics of oral contraceptives. SHARE Study Group. Steroid Hormones and Reproductions.

    abstract::Although past studies have shown that oral contraceptives with 50 microg or more of estrogen reduce the risk of ovarian cancer, it is not clear whether newer, lower-dose formulations do as well. We conducted a population-based, case-control study in the Delaware Valley to assess the impact of dose of oral contraceptio...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/152.3.233

    authors: Ness RB,Grisso JA,Klapper J,Schlesselman JJ,Silberzweig S,Vergona R,Morgan M,Wheeler JE

    更新日期:2000-08-01 00:00:00

  • Association of transposition of the great arteries in infants with maternal exposures to herbicides and rodenticides.

    abstract::The Baltimore-Washington Infant Study, a case-control study of congenital heart defects in liveborn infants conducted in 1981--1989, interviewed parents about a wide range of environmental exposures that occurred during and before the pregnancy. In the period 1987--1989, the questionnaire was expanded to include a det...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/153.6.529

    authors: Loffredo CA,Silbergeld EK,Ferencz C,Zhang J

    更新日期:2001-03-15 00:00:00

  • Use of antibiotics and risk of breast cancer.

    abstract::A recent nested case-control study found that increasing use of antibiotics was associated with a significantly elevated risk of breast cancer. The authors attempted to replicate this finding with a similar study design using the General Practice Research Database in the United Kingdom. Women aged 30-79 years who were...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi087

    authors: García Rodríguez LA,González-Pérez A

    更新日期:2005-04-01 00:00:00

  • Can the Risk of Severe Depression-Related Outcomes be Reduced by Tailoring the Antidepressant Therapy to Patient Characteristics?

    abstract::Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for patients with unipolar depression, yet there is little guidance on which SSRI provides the most benefit to a patient, based on her/his personal characteristics. In this work, we explore whether an individualized treatment strategy can be ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwaa260

    authors: Coulombe J,Moodie EEM,Shortreed SM,Renoux C

    更新日期:2020-12-09 00:00:00

  • Assessing the impact of additional follow-up in cohort studies.

    abstract::An approach is described for predicting the statistical value of extending follow-up in a cohort study. A simple approximation to the expected number of new events of interest is given. The effect of these events on inferences for parameters such as a standardized mortality ratio is approached in two ways. The first c...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114040

    authors: Brookmeyer R,Day N,Pompe-Kirn V

    更新日期:1985-04-01 00:00:00

  • Congenital Abnormalities of the Male Reproductive System and Risk of Autism Spectrum Disorders.

    abstract::Androgens have an extensive influence on brain development in regions of the brain that are relevant for autism spectrum disorder (ASD), yet their etiological involvement remains unclear. Hypospadias (abnormal positioning of the urethral opening) and cryptorchidism (undescended testes) are 2 relatively common male bir...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx367

    authors: Rotem RS,Chodick G,Davidovitch M,Hauser R,Coull BA,Weisskopf MG

    更新日期:2018-04-01 00:00:00

  • Confidence limits made easy: interval estimation using a substitution method.

    abstract::The use of confidence intervals has become standard in the presentation of statistical results in medical journals. Calculation of confidence limits can be straightforward using the normal approximation with an estimate of the standard error, and in particular cases exact solutions can be obtained from published table...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009523

    authors: Daly LE

    更新日期:1998-04-15 00:00:00

  • Protection against ischemic heart disease in the Belgian Physical Fitness Study: physical fitness rather than physical activity?

    abstract::Occupational and leisure time physical activity and conventional risk factors were determined in the Belgian Physical Fitness Study, a prospective study of 2,363 healthy male factory workers who were aged 40-55 years at entry in 1976-1978 and who were followed for five years. Physical fitness, defined as the interpola...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114573

    authors: Sobolski J,Kornitzer M,De Backer G,Dramaix M,Abramowicz M,Degre S,Denolin H

    更新日期:1987-04-01 00:00:00

  • Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.

    abstract::The authors hypothesized that genetic predisposition to diabetes complications would be more evident among low-risk individuals and aimed to identify genes related to developing complications (confirmed distal symmetric polyneuropathy, overt nephropathy, or coronary artery disease) in low-risk groups. Participants in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj287

    authors: Costacou T,Chang Y,Ferrell RE,Orchard TJ

    更新日期:2006-11-01 00:00:00

  • Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.

    abstract::Childhood blood pressure (BP) is a strong predictor of later risk of cardiovascular disease. However, few studies have assessed dynamic BP trajectories throughout the early-life period. We investigated the relationship between early-life factors and systolic BP (SBP) from infancy to adolescence using linear spline mix...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz181

    authors: Aris IM,Rifas-Shiman SL,Li LJ,Belfort MB,Hivert MF,Oken E

    更新日期:2019-11-01 00:00:00

  • Using the Self-Controlled Tree-Temporal Scan Statistic to Assess the Safety of Live Attenuated Herpes Zoster Vaccine.

    abstract::The self-controlled tree-temporal scan statistic allows detection of potential vaccine- or drug-associated adverse events without prespecifying the specific events or postexposure risk intervals of concern. It thus opens a promising new avenue for safety studies. The method has been successfully used to evaluate the s...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwz104

    authors: Yih WK,Kulldorff M,Dashevsky I,Maro JC

    更新日期:2019-07-01 00:00:00

  • Changes in commingled body mass index distributions associated with secular trends in overweight among Danish young men.

    abstract::The authors present results from a novel approach to understanding recent secular trends in overweight in terms of changes in underlying component distributions. On the basis of an examination of two large overlapping samples of Danish young men (ns = 16,557 and 21,747) spanning birth cohorts 1939-1958, the authors fo...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115917

    authors: Price RA,Ness R,Sørensen TI

    更新日期:1991-03-01 00:00:00

  • Measuring dietary change in a diet intervention trial: comparing food frequency questionnaire and dietary recalls.

    abstract::Measurement of dietary change was assessed in a systematic quota subsample (n = 397) of women recruited into the Women's Healthy Eating and Living Study between 1996 and 1998, a multicenter, randomized dietary intervention trial among breast cancer survivors. Women from the intervention and comparison arms completed t...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/aje/kwg025

    authors: Thomson CA,Giuliano A,Rock CL,Ritenbaugh CK,Flatt SW,Faerber S,Newman V,Caan B,Graver E,Hartz V,Whitacre R,Parker F,Pierce JP,Marshall JR

    更新日期:2003-04-15 00:00:00

  • School contact among persons with Hodgkin's disease.

    abstract::The authors evaluated the hypothesis that Hodgkin's disease is transmitted among high school students (in a contagious manner) by determining whether members of a population-based series of young adult cases attended school together more frequently than expected. Cases of Hodgkin's disease were diagnosed from July 1, ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a113871

    authors: Scherr PA,Gutensohn N,Cole P

    更新日期:1984-07-01 00:00:00

  • Geographic representation of the jackson heart study cohort to the African-American population in Jackson, Mississippi.

    abstract::Recent advances in geographic information systems software and multilevel methodology provide opportunities for more extensive characterization of "at-risk" populations in epidemiologic studies. The authors used age-restricted, geocoded data from the all-African-American Jackson Heart Study (JHS), 2000-2004, to demons...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq317

    authors: Hickson DA,Waller LA,Gebreab SY,Wyatt SB,Kelly J,Antoine-Lavigne D,Sarpong DF

    更新日期:2011-01-01 00:00:00

  • Relation between intrauterine growth and subsequent intellectual disability in a ten-year population cohort of children in Western Australia.

    abstract::The authors investigated the association between intrauterine growth and intellectual disability (ID). The appropriateness of intrauterine growth was assessed using percentage of optimal birth weight, a measure that accounts for gestational age, maternal height, parity, and infant sex. Using population-based record li...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm245

    authors: Leonard H,Nassar N,Bourke J,Blair E,Mulroy S,de Klerk N,Bower C

    更新日期:2008-01-01 00:00:00

  • Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women.

    abstract::High-fiber diets are associated with improved lipid profiles. However, pre- and postmenopausal women respond differently to fiber intake, suggesting that endogenous estradiol mediates the effect. The authors' objective was to determine the direct effect of fiber intake on lipoprotein cholesterol levels independent of ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq388

    authors: Mumford SL,Schisterman EF,Siega-Riz AM,Gaskins AJ,Wactawski-Wende J,VanderWeele TJ

    更新日期:2011-01-15 00:00:00

  • Smoking history in middle age and subsequent cognitive performance in elderly Japanese-American men. The Honolulu-Asia Aging Study.

    abstract::The associations between cigarette smoking history and later cognitive performance were examined among 3,429 Japanese-American participants of the Honolulu Heart Program (HHP) and its extension, the Honolulu-Asia Aging Study (HAAS). Cognitive performance was measured by the Cognitive Abilities Screening Instrument (CA...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a009138

    authors: Galanis DJ,Petrovitch H,Launer LJ,Harris TB,Foley DJ,White LR

    更新日期:1997-03-15 00:00:00